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Mutation of the receptor tyrosine phosphatase PTPRC (CD45) in T-cell acute lymphoblastic leukemia.

Porcu M, Kleppe M, Gianfelici V, Geerdens E, De Keersmaecker K, Tartaglia M, Foà R, Soulier J, Cauwelier B, Uyttebroeck A, Macintyre E, Vandenberghe P, Asnafi V, Cools J.

Blood. 2012 May 10;119(19):4476-9. doi: 10.1182/blood-2011-09-379958. Epub 2012 Mar 21.


PTPN2 negatively regulates oncogenic JAK1 in T-cell acute lymphoblastic leukemia.

Kleppe M, Soulier J, Asnafi V, Mentens N, Hornakova T, Knoops L, Constantinescu S, Sigaux F, Meijerink JP, Vandenberghe P, Tartaglia M, Foa R, Macintyre E, Haferlach T, Cools J.

Blood. 2011 Jun 30;117(26):7090-8. doi: 10.1182/blood-2010-10-314286. Epub 2011 May 6.


Mutation analysis of the tyrosine phosphatase PTPN2 in Hodgkin's lymphoma and T-cell non-Hodgkin's lymphoma.

Kleppe M, Tousseyn T, Geissinger E, Kalender Atak Z, Aerts S, Rosenwald A, Wlodarska I, Cools J.

Haematologica. 2011 Nov;96(11):1723-7. doi: 10.3324/haematol.2011.041921. Epub 2011 Jul 26.


Combined gene expression and DNA occupancy profiling identifies potential therapeutic targets of t(8;21) AML.

Lo MC, Peterson LF, Yan M, Cong X, Jin F, Shia WJ, Matsuura S, Ahn EY, Komeno Y, Ly M, Ommen HB, Chen IM, Hokland P, Willman CL, Ren B, Zhang DE.

Blood. 2012 Aug 16;120(7):1473-84. doi: 10.1182/blood-2011-12-395335. Epub 2012 Jun 26.


CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling.

Irie-Sasaki J, Sasaki T, Matsumoto W, Opavsky A, Cheng M, Welstead G, Griffiths E, Krawczyk C, Richardson CD, Aitken K, Iscove N, Koretzky G, Johnson P, Liu P, Rothstein DM, Penninger JM.

Nature. 2001 Jan 18;409(6818):349-54.


Consequences of increased CD45RA and RC isoforms for TCR signaling and peripheral T cell deficiency resulting from heterogeneous nuclear ribonucleoprotein L-like mutation.

Wu Z, Yates AL, Hoyne GF, Goodnow CC.

J Immunol. 2010 Jul 1;185(1):231-8. doi: 10.4049/jimmunol.0903625. Epub 2010 May 26.


CD45 recruits adapter protein DOK-1 and negatively regulates JAK-STAT signaling in hematopoietic cells.

Wu L, Bijian K, Shen SH.

Mol Immunol. 2009 Jul;46(11-12):2167-77. doi: 10.1016/j.molimm.2009.04.032. Epub 2009 May 28. Erratum in: Mol Immunol. 2010 Jan;47(4):41. Shen, Shi-Shiang [corrected to Shen, Shi-Hsiang].


Notch-1 regulates Akt signaling pathway and the expression of cell cycle regulatory proteins cyclin D1, CDK2 and p21 in T-ALL cell lines.

Guo D, Ye J, Dai J, Li L, Chen F, Ma D, Ji C.

Leuk Res. 2009 May;33(5):678-85. doi: 10.1016/j.leukres.2008.10.026. Epub 2008 Dec 17.


The CD45 tyrosine phosphatase regulates specific pools of antigen receptor-associated p59fyn and CD4-associated p56lck tyrosine in human T-cells.

Biffen M, McMichael-Phillips D, Larson T, Venkitaraman A, Alexander D.

EMBO J. 1994 Apr 15;13(8):1920-9.


CD45 antigen negativity in T-lineage ALL correlates with PTPRC mutation and sensitivity to a selective JAK inhibitor.

Raponi S, Gianfelici V, Chiaretti S, Peragine N, Brugnoletti F, De Propris MS, Marinelli M, Hulselmans G, Aerts S, Geerdens E, Cools J, Foà R, Guarini A.

Br J Haematol. 2015 Dec;171(5):884-7. doi: 10.1111/bjh.13448. Epub 2015 Apr 8. No abstract available.


New insights into the transmembrane protein tyrosine phosphatase CD45.

Sasaki T, Sasaki-Irie J, Penninger JM.

Int J Biochem Cell Biol. 2001 Nov;33(11):1041-6. Review.


The catalytic activity of the CD45 membrane-proximal phosphatase domain is required for TCR signaling and regulation.

Desai DM, Sap J, Silvennoinen O, Schlessinger J, Weiss A.

EMBO J. 1994 Sep 1;13(17):4002-10.


Collagen-mediated survival signaling is modulated by CD45 in Jurkat T cells.

Bijian K, Zhang L, Shen SH.

Mol Immunol. 2007 Jul;44(15):3682-90. Epub 2007 May 23.


Interleukin-7 receptor mutants initiate early T cell precursor leukemia in murine thymocyte progenitors with multipotent potential.

Treanor LM, Zhou S, Janke L, Churchman ML, Ma Z, Lu T, Chen SC, Mullighan CG, Sorrentino BP.

J Exp Med. 2014 Apr 7;211(4):701-13. doi: 10.1084/jem.20122727. Epub 2014 Mar 31.


β-Escin sodium inhibits inducible nitric oxide synthase expression via downregulation of the JAK/STAT pathway in A549 cells.

Ji DB, Xu B, Liu JT, Ran FX, Cui JR.

Mol Carcinog. 2011 Dec;50(12):945-60. doi: 10.1002/mc.20762. Epub 2011 Mar 11.


Targeted sequencing identifies associations between IL7R-JAK mutations and epigenetic modulators in T-cell acute lymphoblastic leukemia.

Vicente C, Schwab C, Broux M, Geerdens E, Degryse S, Demeyer S, Lahortiga I, Elliott A, Chilton L, La Starza R, Mecucci C, Vandenberghe P, Goulden N, Vora A, Moorman AV, Soulier J, Harrison CJ, Clappier E, Cools J.

Haematologica. 2015 Oct;100(10):1301-10. doi: 10.3324/haematol.2015.130179. Epub 2015 Jul 23.


Notch-mediated repression of miR-223 contributes to IGF1R regulation in T-ALL.

Gusscott S, Kuchenbauer F, Humphries RK, Weng AP.

Leuk Res. 2012 Jul;36(7):905-11. doi: 10.1016/j.leukres.2012.02.013. Epub 2012 Mar 17.

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