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Results: 1 to 20 of 111

1.

Role of transglutaminase 2 in celiac disease pathogenesis.

Klöck C, Diraimondo TR, Khosla C.

Semin Immunopathol. 2012 Jul;34(4):513-22. doi: 10.1007/s00281-012-0305-0. Epub 2012 Mar 22. Review.

PMID:
22437759
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Activation and inhibition of transglutaminase 2 in mice.

Dafik L, Albertelli M, Stamnaes J, Sollid LM, Khosla C.

PLoS One. 2012;7(2):e30642. doi: 10.1371/journal.pone.0030642. Epub 2012 Feb 2.

PMID:
22319575
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Are transglutaminase 2 inhibitors able to reduce gliadin-induced toxicity related to celiac disease? A proof-of-concept study.

Rauhavirta T, Oittinen M, Kivistö R, Männistö PT, Garcia-Horsman JA, Wang Z, Griffin M, Mäki M, Kaukinen K, Lindfors K.

J Clin Immunol. 2013 Jan;33(1):134-42. doi: 10.1007/s10875-012-9745-5. Epub 2012 Aug 10.

PMID:
22878839
[PubMed - indexed for MEDLINE]
4.

New therapeutic strategies for coeliac disease: tissue transglutaminase as a target.

Esposito C, Caputo I, Troncone R.

Curr Med Chem. 2007;14(24):2572-80. Review.

PMID:
17979710
[PubMed - indexed for MEDLINE]
5.

Gliadin T cell epitope selection by tissue transglutaminase in celiac disease. Role of enzyme specificity and pH influence on the transamidation versus deamidation process.

Fleckenstein B, Molberg Ø, Qiao SW, Schmid DG, von der Mülbe F, Elgstøen K, Jung G, Sollid LM.

J Biol Chem. 2002 Sep 13;277(37):34109-16. Epub 2002 Jul 1.

PMID:
12093810
[PubMed - indexed for MEDLINE]
Free Article
6.

Transglutaminase 2 inhibitors and their therapeutic role in disease states.

Siegel M, Khosla C.

Pharmacol Ther. 2007 Aug;115(2):232-45. Epub 2007 May 13. Review.

PMID:
17582505
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Transglutaminase 2-targeted autoantibodies in celiac disease: Pathogenetic players in addition to diagnostic tools?

Lindfors K, Mäki M, Kaukinen K.

Autoimmun Rev. 2010 Sep;9(11):744-9. doi: 10.1016/j.autrev.2010.06.003. Epub 2010 Jun 12. Review.

PMID:
20547248
[PubMed - indexed for MEDLINE]
8.

Design, synthesis, and evaluation of gluten peptide analogs as selective inhibitors of human tissue transglutaminase.

Hausch F, Halttunen T, Mäki M, Khosla C.

Chem Biol. 2003 Mar;10(3):225-31.

PMID:
12670536
[PubMed - indexed for MEDLINE]
Free Article
9.

The preferred substrates for transglutaminase 2 in a complex wheat gluten digest are Peptide fragments harboring celiac disease T-cell epitopes.

Dørum S, Arntzen MØ, Qiao SW, Holm A, Koehler CJ, Thiede B, Sollid LM, Fleckenstein B.

PLoS One. 2010 Nov 19;5(11):e14056. doi: 10.1371/journal.pone.0014056.

PMID:
21124911
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Transglutaminase 2 undergoes a large conformational change upon activation.

Pinkas DM, Strop P, Brunger AT, Khosla C.

PLoS Biol. 2007 Dec;5(12):e327.

PMID:
18092889
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Interferon-γ activates transglutaminase 2 via a phosphatidylinositol-3-kinase-dependent pathway: implications for celiac sprue therapy.

Diraimondo TR, Klöck C, Khosla C.

J Pharmacol Exp Ther. 2012 Apr;341(1):104-14. doi: 10.1124/jpet.111.187385. Epub 2012 Jan 6.

PMID:
22228808
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Transglutaminase 2 in celiac disease: minireview article.

Caputo I, D'Amato A, Troncone R, Auricchio S, Esposito C.

Amino Acids. 2004 Jul;26(4):381-6. Epub 2004 Apr 14. Review.

PMID:
15290344
[PubMed - indexed for MEDLINE]
13.

Tissue transglutaminase-mediated formation and cleavage of histamine-gliadin complexes: biological effects and implications for celiac disease.

Qiao SW, Piper J, Haraldsen G, Oynebråten I, Fleckenstein B, Molberg O, Khosla C, Sollid LM.

J Immunol. 2005 Feb 1;174(3):1657-63.

PMID:
15661929
[PubMed - indexed for MEDLINE]
Free Article
14.

Activation of extracellular transglutaminase 2 by thioredoxin.

Jin X, Stamnaes J, Klöck C, DiRaimondo TR, Sollid LM, Khosla C.

J Biol Chem. 2011 Oct 28;286(43):37866-73. doi: 10.1074/jbc.M111.287490. Epub 2011 Sep 9.

PMID:
21908620
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Deamidation and cross-linking of gliadin peptides by transglutaminases and the relation to celiac disease.

Skovbjerg H, Koch C, Anthonsen D, Sjöström H.

Biochim Biophys Acta. 2004 Nov 5;1690(3):220-30.

PMID:
15511629
[PubMed - indexed for MEDLINE]
Free Article
16.

Acylideneoxoindoles: a new class of reversible inhibitors of human transglutaminase 2.

Klöck C, Jin X, Choi K, Khosla C, Madrid PB, Spencer A, Raimundo BC, Boardman P, Lanza G, Griffin JH.

Bioorg Med Chem Lett. 2011 May 1;21(9):2692-6. doi: 10.1016/j.bmcl.2010.12.037. Epub 2010 Dec 16.

PMID:
21215619
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Unexpected role of surface transglutaminase type II in celiac disease.

Maiuri L, Ciacci C, Ricciardelli I, Vacca L, Raia V, Rispo A, Griffin M, Issekutz T, Quaratino S, Londei M.

Gastroenterology. 2005 Nov;129(5):1400-13.

PMID:
16285941
[PubMed - indexed for MEDLINE]
18.

A single conformational transglutaminase 2 epitope contributed by three domains is critical for celiac antibody binding and effects.

Simon-Vecsei Z, Király R, Bagossi P, Tóth B, Dahlbom I, Caja S, Csosz É, Lindfors K, Sblattero D, Nemes É, Mäki M, Fésüs L, Korponay-Szabó IR.

Proc Natl Acad Sci U S A. 2012 Jan 10;109(2):431-6. doi: 10.1073/pnas.1107811108. Epub 2011 Dec 22.

PMID:
22198767
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Transglutaminase 2 is expressed and active on the surface of human monocyte-derived dendritic cells and macrophages.

Hodrea J, Demény MA, Majai G, Sarang Z, Korponay-Szabó IR, Fésüs L.

Immunol Lett. 2010 May 4;130(1-2):74-81. doi: 10.1016/j.imlet.2009.12.010. Epub 2010 Feb 10.

PMID:
20005901
[PubMed - indexed for MEDLINE]
20.

High abundance of plasma cells secreting transglutaminase 2-specific IgA autoantibodies with limited somatic hypermutation in celiac disease intestinal lesions.

Di Niro R, Mesin L, Zheng NY, Stamnaes J, Morrissey M, Lee JH, Huang M, Iversen R, du Pré MF, Qiao SW, Lundin KE, Wilson PC, Sollid LM.

Nat Med. 2012 Feb 26;18(3):441-5. doi: 10.1038/nm.2656.

PMID:
22366952
[PubMed - indexed for MEDLINE]

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