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Results: 1 to 20 of 93

Similar articles for PubMed (Select 22428803)

1.

Improvement of inhibitor identification for heat shock protein 90α by utilizing a red-shifted fluorescence polarization probe.

Qian J, Holskin BP, Theroff J, Underiner T, Meyer SL, Angeles TS.

Assay Drug Dev Technol. 2012 Aug;10(4):375-81. doi: 10.1089/adt.2011.429. Epub 2012 Mar 19.

PMID:
22428803
2.

Development of a fluorescence polarization assay for the molecular chaperone Hsp90.

Kim J, Felts S, Llauger L, He H, Huezo H, Rosen N, Chiosis G.

J Biomol Screen. 2004 Aug;9(5):375-81.

PMID:
15296636
3.

Mechanistic studies on Hsp90 inhibition by ansamycin derivatives.

Onuoha SC, Mukund SR, Coulstock ET, SengerovĂ  B, Shaw J, McLaughlin SH, Jackson SE.

J Mol Biol. 2007 Sep 14;372(2):287-97. Epub 2007 Jun 29.

PMID:
17662999
4.

Synthesis of a red-shifted fluorescence polarization probe for Hsp90.

Moulick K, Clement CC, Aguirre J, Kim J, Kang Y, Felts S, Chiosis G.

Bioorg Med Chem Lett. 2006 Sep 1;16(17):4515-8. Epub 2006 Jun 22.

PMID:
16797988
5.

Assay strategies for the discovery and validation of therapeutics targeting Brugia pahangi Hsp90.

Taldone T, Gillan V, Sun W, Rodina A, Patel P, Maitland K, O'Neill K, Chiosis G, Devaney E.

PLoS Negl Trop Dis. 2010 Jun 15;4(6):e714. doi: 10.1371/journal.pntd.0000714.

6.

Heat shock protein 90 regulates the stability of MEKK3 in HEK293 cells.

Fang S, Fu J, Yuan X, Han C, Shi L, Xin Y, Luo L, Yin Z.

Cell Immunol. 2009;259(1):49-55. doi: 10.1016/j.cellimm.2009.05.012. Epub 2009 Jun 6.

PMID:
19560753
7.

A cell-based screen for inhibitors of protein folding and degradation.

Boschelli F, Golas JM, Petersen R, Lau V, Chen L, Tkach D, Zhao Q, Fruhling DS, Liu H, Nam C, Arndt KT.

Cell Stress Chaperones. 2010 Nov;15(6):913-27. doi: 10.1007/s12192-010-0200-3. Epub 2010 Aug 19.

8.

High-throughput screening fluorescence polarization assay for tumor-specific Hsp90.

Du Y, Moulick K, Rodina A, Aguirre J, Felts S, Dingledine R, Fu H, Chiosis G.

J Biomol Screen. 2007 Oct;12(7):915-24.

PMID:
17942784
10.

Targeting of multiple signalling pathways by heat shock protein 90 molecular chaperone inhibitors.

Powers MV, Workman P.

Endocr Relat Cancer. 2006 Dec;13 Suppl 1:S125-35. Review.

11.

High-throughput screening assay for inhibitors of heat-shock protein 90 ATPase activity.

Rowlands MG, Newbatt YM, Prodromou C, Pearl LH, Workman P, Aherne W.

Anal Biochem. 2004 Apr 15;327(2):176-83.

PMID:
15051534
12.

Solid-phase immunoassays in mechanism-based drug discovery: their application in the development of inhibitors of the molecular chaperone heat-shock protein 90.

Hardcastle A, Boxall K, Richards J, Tomlin P, Sharp S, Clarke P, Workman P, Aherne W.

Assay Drug Dev Technol. 2005 Jun;3(3):273-85.

PMID:
15971989
13.

Molecular characterization of macbecin as an Hsp90 inhibitor.

Martin CJ, Gaisser S, Challis IR, Carletti I, Wilkinson B, Gregory M, Prodromou C, Roe SM, Pearl LH, Boyd SM, Zhang MQ.

J Med Chem. 2008 May 8;51(9):2853-7. doi: 10.1021/jm701558c. Epub 2008 Mar 22.

PMID:
18357975
14.
15.

Drug-mediated targeted disruption of multiple protein activities through functional inhibition of the Hsp90 chaperone complex.

Stravopodis DJ, Margaritis LH, Voutsinas GE.

Curr Med Chem. 2007;14(29):3122-38. Review.

PMID:
18220746
16.

Design, synthesis, and biological evaluation of hydroquinone derivatives of 17-amino-17-demethoxygeldanamycin as potent, water-soluble inhibitors of Hsp90.

Ge J, Normant E, Porter JR, Ali JA, Dembski MS, Gao Y, Georges AT, Grenier L, Pak RH, Patterson J, Sydor JR, Tibbitts TT, Tong JK, Adams J, Palombella VJ.

J Med Chem. 2006 Jul 27;49(15):4606-15.

PMID:
16854066
17.

A fluorescence polarization assay for inhibitors of Hsp90.

Howes R, Barril X, Dymock BW, Grant K, Northfield CJ, Robertson AG, Surgenor A, Wayne J, Wright L, James K, Matthews T, Cheung KM, McDonald E, Workman P, Drysdale MJ.

Anal Biochem. 2006 Mar 15;350(2):202-13. Epub 2006 Jan 23.

PMID:
16460658
18.

Concerted actions of multiple transcription elements confer differential transactivation of HSP90 isoforms in geldanamycin-treated 9L rat gliosarcoma cells.

Chao CC, Sun FC, Wang CH, Lo CW, Chang YS, Chang KC, Chang MD, Lai YK.

J Cell Biochem. 2008 Jul 1;104(4):1286-96. doi: 10.1002/jcb.21705.

PMID:
18320580
19.

Fluorine- and rhenium-containing geldanamycin derivatives as leads for the development of molecular probes for imaging Hsp90.

Wuest F, Bouvet V, Mai B, LaPointe P.

Org Biomol Chem. 2012 Sep 7;10(33):6724-31. doi: 10.1039/c2ob25744k. Epub 2012 Jul 24.

PMID:
22825378
20.

Design, synthesis, and structure--activity relationships for chimeric inhibitors of Hsp90.

Shen G, Wang M, Welch TR, Blagg BS.

J Org Chem. 2006 Sep 29;71(20):7618-31.

PMID:
16995666
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