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Items: 1 to 20 of 136


Natural product biosynthetic gene diversity in geographically distinct soil microbiomes.

Reddy BV, Kallifidas D, Kim JH, Charlop-Powers Z, Feng Z, Brady SF.

Appl Environ Microbiol. 2012 May;78(10):3744-52. doi: 10.1128/AEM.00102-12. Epub 2012 Mar 16.


Mapping gene clusters within arrayed metagenomic libraries to expand the structural diversity of biomedically relevant natural products.

Owen JG, Reddy BV, Ternei MA, Charlop-Powers Z, Calle PY, Kim JH, Brady SF.

Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):11797-802. doi: 10.1073/pnas.1222159110. Epub 2013 Jul 3.


Global biogeographic sampling of bacterial secondary metabolism.

Charlop-Powers Z, Owen JG, Reddy BV, Ternei MA, Guimarães DO, de Frias UA, Pupo MT, Seepe P, Feng Z, Brady SF.

Elife. 2015 Jan 19;4:e05048. doi: 10.7554/eLife.05048.


Chemical-biogeographic survey of secondary metabolism in soil.

Charlop-Powers Z, Owen JG, Reddy BV, Ternei MA, Brady SF.

Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3757-62. doi: 10.1073/pnas.1318021111. Epub 2014 Feb 18.


Deep sequencing of non-ribosomal peptide synthetases and polyketide synthases from the microbiomes of Australian marine sponges.

Woodhouse JN, Fan L, Brown MV, Thomas T, Neilan BA.

ISME J. 2013 Sep;7(9):1842-51. doi: 10.1038/ismej.2013.65. Epub 2013 Apr 18.


Functional analysis of environmental DNA-derived type II polyketide synthases reveals structurally diverse secondary metabolites.

Feng Z, Kallifidas D, Brady SF.

Proc Natl Acad Sci U S A. 2011 Aug 2;108(31):12629-34. doi: 10.1073/pnas.1103921108. Epub 2011 Jul 18.


A functional screen for recovery of 4'-phosphopantetheinyl transferase and associated natural product biosynthesis genes from metagenome libraries.

Owen JG, Robins KJ, Parachin NS, Ackerley DF.

Environ Microbiol. 2012 May;14(5):1198-209. doi: 10.1111/j.1462-2920.2012.02699.x. Epub 2012 Feb 22.


Mining soil metagenomes to better understand the evolution of natural product structural diversity: pentangular polyphenols as a case study.

Kang HS, Brady SF.

J Am Chem Soc. 2014 Dec 31;136(52):18111-9. doi: 10.1021/ja510606j. Epub 2014 Dec 18.


The natural product domain seeker NaPDoS: a phylogeny based bioinformatic tool to classify secondary metabolite gene diversity.

Ziemert N, Podell S, Penn K, Badger JH, Allen E, Jensen PR.

PLoS One. 2012;7(3):e34064. doi: 10.1371/journal.pone.0034064. Epub 2012 Mar 29.


Geographic distribution of secondary metabolite genes in the marine actinomycete Salinispora arenicola.

Edlund A, Loesgen S, Fenical W, Jensen PR.

Appl Environ Microbiol. 2011 Sep;77(17):5916-25. doi: 10.1128/AEM.00611-11. Epub 2011 Jul 1.


Reassembly of functionally intact environmental DNA-derived biosynthetic gene clusters.

Kallifidas D, Brady SF.

Methods Enzymol. 2012;517:225-39. doi: 10.1016/B978-0-12-404634-4.00011-5.


Diversity of microbes associated with the marine sponge, Haliclona simulans, isolated from Irish waters and identification of polyketide synthase genes from the sponge metagenome.

Kennedy J, Codling CE, Jones BV, Dobson AD, Marchesi JR.

Environ Microbiol. 2008 Jul;10(7):1888-902. doi: 10.1111/j.1462-2920.2008.01614.x. Epub 2008 Apr 21.


Identification of unique type II polyketide synthase genes in soil.

Wawrik B, Kerkhof L, Zylstra GJ, Kukor JJ.

Appl Environ Microbiol. 2005 May;71(5):2232-8.


Horizon-specific bacterial community composition of German grassland soils, as revealed by pyrosequencing-based analysis of 16S rRNA genes.

Will C, Thürmer A, Wollherr A, Nacke H, Herold N, Schrumpf M, Gutknecht J, Wubet T, Buscot F, Daniel R.

Appl Environ Microbiol. 2010 Oct;76(20):6751-9. doi: 10.1128/AEM.01063-10. Epub 2010 Aug 20.


Diversity analysis of type I ketosynthase in rhizosphere soil of cucumber.

Zhao B, Gao Z, Shao Y, Yan J, Hu Y, Yu J, Liu Q, Chen F.

J Basic Microbiol. 2012 Apr;52(2):224-31. doi: 10.1002/jobm.201000455. Epub 2011 Jul 21.


Diversity and distribution of microbial long-chain fatty acid biosynthetic genes in the marine environment.

Shulse CN, Allen EE.

Environ Microbiol. 2011 Mar;13(3):684-95. doi: 10.1111/j.1462-2920.2010.02373.x. Epub 2010 Nov 24.


Multiplexed metagenome mining using short DNA sequence tags facilitates targeted discovery of epoxyketone proteasome inhibitors.

Owen JG, Charlop-Powers Z, Smith AG, Ternei MA, Calle PY, Reddy BV, Montiel D, Brady SF.

Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):4221-6. doi: 10.1073/pnas.1501124112. Epub 2015 Mar 23.


Polyketide synthase pathways identified from a metagenomic library are derived from soil Acidobacteria.

Parsley LC, Linneman J, Goode AM, Becklund K, George I, Goodman RM, Lopanik NB, Liles MR.

FEMS Microbiol Ecol. 2011 Oct;78(1):176-87. doi: 10.1111/j.1574-6941.2011.01122.x. Epub 2011 May 23.


Diversity of polyketide synthase gene sequences in Aspergillus species.

Varga J, Rigó K, Kocsubé S, Farkas B, Pál K.

Res Microbiol. 2003 Oct;154(8):593-600.

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