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Results: 1 to 20 of 161

1.

Regulation of mTOR complex 2 signaling in neurofibromatosis 2-deficient target cell types.

James MF, Stivison E, Beauchamp R, Han S, Li H, Wallace MR, Gusella JF, Stemmer-Rachamimov AO, Ramesh V.

Mol Cancer Res. 2012 May;10(5):649-59. doi: 10.1158/1541-7786.MCR-11-0425-T. Epub 2012 Mar 16.

PMID:
22426462
[PubMed - indexed for MEDLINE]
Free Article
2.

NF2/merlin is a novel negative regulator of mTOR complex 1, and activation of mTORC1 is associated with meningioma and schwannoma growth.

James MF, Han S, Polizzano C, Plotkin SR, Manning BD, Stemmer-Rachamimov AO, Gusella JF, Ramesh V.

Mol Cell Biol. 2009 Aug;29(15):4250-61. doi: 10.1128/MCB.01581-08. Epub 2009 May 18.

PMID:
19451225
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

The neurofibromatosis 2 tumor suppressor gene product, merlin, regulates human meningioma cell growth by signaling through YAP.

Striedinger K, VandenBerg SR, Baia GS, McDermott MW, Gutmann DH, Lal A.

Neoplasia. 2008 Nov;10(11):1204-12.

PMID:
18953429
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Loss of the tumor suppressor gene NF2, encoding merlin, constitutively activates integrin-dependent mTORC1 signaling.

López-Lago MA, Okada T, Murillo MM, Socci N, Giancotti FG.

Mol Cell Biol. 2009 Aug;29(15):4235-49. doi: 10.1128/MCB.01578-08. Epub 2009 May 18.

PMID:
19451229
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Modeling NF2 with human arachnoidal and meningioma cell culture systems: NF2 silencing reflects the benign character of tumor growth.

James MF, Lelke JM, Maccollin M, Plotkin SR, Stemmer-Rachamimov AO, Ramesh V, Gusella JF.

Neurobiol Dis. 2008 Feb;29(2):278-92. Epub 2007 Sep 19.

PMID:
17962031
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Merlin/NF2 regulates angiogenesis in schwannomas through a Rac1/semaphorin 3F-dependent mechanism.

Wong HK, Shimizu A, Kirkpatrick ND, Garkavtsev I, Chan AW, di Tomaso E, Klagsbrun M, Jain RK.

Neoplasia. 2012 Feb;14(2):84-94.

PMID:
22431917
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Calpain-dependent proteolysis of NF2 protein: involvement in schwannomas and meningiomas.

Kimura Y, Saya H, Nakao M.

Neuropathology. 2000 Sep;20(3):153-60. Review.

PMID:
11132929
[PubMed - indexed for MEDLINE]
8.

Expression of NF2 gene product merlin in arachnoid villi and meningiomas.

Sakuda K, Kohda Y, Matsumoto T, Park C, Seto A, Tohma Y, Hasegawa M, Kida S, Nitta H, Yamashima T, Yamashita J.

Noshuyo Byori. 1996 Nov;13(2):145-8.

PMID:
8958521
[PubMed - indexed for MEDLINE]
9.

The role of insulin-like growth factors signaling in merlin-deficient human schwannomas.

Ammoun S, Schmid MC, Ristic N, Zhou L, Hilton D, Ercolano E, Carroll C, Hanemann CO.

Glia. 2012 Nov;60(11):1721-33. doi: 10.1002/glia.22391. Epub 2012 Jul 20.

PMID:
22821509
[PubMed - indexed for MEDLINE]
10.

Loss of merlin expression in sporadic meningiomas, ependymomas and schwannomas.

Gutmann DH, Giordano MJ, Fishback AS, Guha A.

Neurology. 1997 Jul;49(1):267-70.

PMID:
9222206
[PubMed - indexed for MEDLINE]
11.

Expression of the tumor suppressor genes NF2, 4.1B, and TSLC1 in canine meningiomas.

Dickinson PJ, Surace EI, Cambell M, Higgins RJ, Leutenegger CM, Bollen AW, LeCouteur RA, Gutmann DH.

Vet Pathol. 2009 Sep;46(5):884-92. doi: 10.1354/vp.08-VP-0251-D-FL. Epub 2009 May 9.

PMID:
19429976
[PubMed - indexed for MEDLINE]
Free Article
12.

Merlin-deficient human tumors show loss of contact inhibition and activation of Wnt/β-catenin signaling linked to the PDGFR/Src and Rac/PAK pathways.

Zhou L, Ercolano E, Ammoun S, Schmid MC, Barczyk MA, Hanemann CO.

Neoplasia. 2011 Dec;13(12):1101-12.

PMID:
22247700
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2.

Feldman ME, Apsel B, Uotila A, Loewith R, Knight ZA, Ruggero D, Shokat KM.

PLoS Biol. 2009 Feb 10;7(2):e38. doi: 10.1371/journal.pbio.1000038.

PMID:
19209957
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Signaling events downstream of mammalian target of rapamycin complex 2 are attenuated in cells and tumors deficient for the tuberous sclerosis complex tumor suppressors.

Huang J, Wu S, Wu CL, Manning BD.

Cancer Res. 2009 Aug 1;69(15):6107-14. doi: 10.1158/0008-5472.CAN-09-0975. Epub 2009 Jul 14.

PMID:
19602587
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

The involvement of calpain-dependent proteolysis of the tumor suppressor NF2 (merlin) in schwannomas and meningiomas.

Kimura Y, Koga H, Araki N, Mugita N, Fujita N, Takeshima H, Nishi T, Yamashima T, Saido TC, Yamasaki T, Moritake K, Saya H, Nakao M.

Nat Med. 1998 Aug;4(8):915-22.

PMID:
9701243
[PubMed - indexed for MEDLINE]
16.

The neurofibromatosis type 2 gene product, merlin, reverses the F-actin cytoskeletal defects in primary human Schwannoma cells.

Bashour AM, Meng JJ, Ip W, MacCollin M, Ratner N.

Mol Cell Biol. 2002 Feb;22(4):1150-7.

PMID:
11809806
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

mTORC1 enhancement of STIM1-mediated store-operated Ca2+ entry constrains tuberous sclerosis complex-related tumor development.

Peng H, Liu J, Sun Q, Chen R, Wang Y, Duan J, Li C, Li B, Jing Y, Chen X, Mao Q, Xu KF, Walker CL, Li J, Wang J, Zhang H.

Oncogene. 2013 Sep 26;32(39):4702-11. doi: 10.1038/onc.2012.481. Epub 2012 Oct 29.

PMID:
23108404
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Merlin regulates transmembrane receptor accumulation and signaling at the plasma membrane in primary mouse Schwann cells and in human schwannomas.

Lallemand D, Manent J, Couvelard A, Watilliaux A, Siena M, Chareyre F, Lampin A, Niwa-Kawakita M, Kalamarides M, Giovannini M.

Oncogene. 2009 Feb 12;28(6):854-65. doi: 10.1038/onc.2008.427. Epub 2008 Nov 24.

PMID:
19029950
[PubMed - indexed for MEDLINE]
19.

Inhibition of PI3K-Akt-mTOR signaling in glioblastoma by mTORC1/2 inhibitors.

Fan QW, Weiss WA.

Methods Mol Biol. 2012;821:349-59. doi: 10.1007/978-1-61779-430-8_22.

PMID:
22125077
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Axl/Gas6/NFκB signalling in schwannoma pathological proliferation, adhesion and survival.

Ammoun S, Provenzano L, Zhou L, Barczyk M, Evans K, Hilton DA, Hafizi S, Hanemann CO.

Oncogene. 2014 Jan 16;33(3):336-46. doi: 10.1038/onc.2012.587. Epub 2013 Jan 14.

PMID:
23318455
[PubMed - indexed for MEDLINE]
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