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Items: 1 to 20 of 142

1.

Development of clickable active site-directed photoaffinity probes for γ-secretase.

Crump CJ, am Ende CW, Ballard TE, Pozdnyakov N, Pettersson M, Chau DM, Bales KR, Li YM, Johnson DS.

Bioorg Med Chem Lett. 2012 Apr 15;22(8):2997-3000. doi: 10.1016/j.bmcl.2012.02.027. Epub 2012 Feb 20.

2.

γ-Secretase modulator (GSM) photoaffinity probes reveal distinct allosteric binding sites on presenilin.

Pozdnyakov N, Murrey HE, Crump CJ, Pettersson M, Ballard TE, Am Ende CW, Ahn K, Li YM, Bales KR, Johnson DS.

J Biol Chem. 2013 Apr 5;288(14):9710-20. doi: 10.1074/jbc.M112.398602. Epub 2013 Feb 8.

3.

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1.

Li YM, Xu M, Lai MT, Huang Q, Castro JL, DiMuzio-Mower J, Harrison T, Lellis C, Nadin A, Neduvelil JG, Register RB, Sardana MK, Shearman MS, Smith AL, Shi XP, Yin KC, Shafer JA, Gardell SJ.

Nature. 2000 Jun 8;405(6787):689-94.

PMID:
10864326
4.

Development of Sulfonamide Photoaffinity Inhibitors for Probing Cellular γ-Secretase.

Crump CJ, Murrey HE, Ballard TE, Am Ende CW, Wu X, Gertsik N, Johnson DS, Li YM.

ACS Chem Neurosci. 2016 Jun 17. [Epub ahead of print]

PMID:
27253220
5.

Phosphatidylinositol 3,4,5-trisphosphate activity probes for the labeling and proteomic characterization of protein binding partners.

Rowland MM, Bostic HE, Gong D, Speers AE, Lucas N, Cho W, Cravatt BF, Best MD.

Biochemistry. 2011 Dec 27;50(51):11143-61. doi: 10.1021/bi201636s. Epub 2011 Nov 30.

6.

Development of photoaffinity probes for gamma-secretase equipped with a nitrobenzenesulfonamide-type cleavable linker.

Yokoshima S, Abe Y, Watanabe N, Kita Y, Kan T, Iwatsubo T, Tomita T, Fukuyama T.

Bioorg Med Chem Lett. 2009 Dec 15;19(24):6869-71. doi: 10.1016/j.bmcl.2009.10.086. Epub 2009 Oct 23. Erratum in: Bioorg Med Chem Lett. 2010 Mar 1;20(5):1798-9.

PMID:
19892551
7.

Signal peptide peptidase forms a homodimer that is labeled by an active site-directed gamma-secretase inhibitor.

Nyborg AC, Kornilova AY, Jansen K, Ladd TB, Wolfe MS, Golde TE.

J Biol Chem. 2004 Apr 9;279(15):15153-60. Epub 2004 Jan 2.

8.

γ-Secretase Inhibitors and Modulators Induce Distinct Conformational Changes in the Active Sites of γ-Secretase and Signal Peptide Peptidase.

Gertsik N, Chau DM, Li YM.

ACS Chem Biol. 2015 Aug 21;10(8):1925-31. doi: 10.1021/acschembio.5b00321. Epub 2015 Jun 10.

PMID:
26030233
9.

Development of CBAP-BPyne, a probe for γ-secretase and presenilinase.

Gertsik N, Ballard TE, Am Ende CW, Johnson DS, Li YM.

Medchemcomm. 2014 Mar;5(3):338-341.

10.

Divergent synthesis of multifunctional molecular probes to elucidate the enzyme specificity of dipeptidic gamma-secretase inhibitors.

Fuwa H, Takahashi Y, Konno Y, Watanabe N, Miyashita H, Sasaki M, Natsugari H, Kan T, Fukuyama T, Tomita T, Iwatsubo T.

ACS Chem Biol. 2007 Jun 15;2(6):408-18. Epub 2007 May 25.

PMID:
17530731
11.

Synthesis of biotinylated photoaffinity probes based on arylsulfonamide gamma-secretase inhibitors.

Fuwa H, Hiromoto K, Takahashi Y, Yokoshima S, Kan T, Fukuyama T, Iwatsubo T, Tomita T, Natsugari H.

Bioorg Med Chem Lett. 2006 Aug 15;16(16):4184-9.

PMID:
16766183
12.

Development of benzophenone-alkyne bifunctional sigma receptor ligands.

Guo LW, Hajipour AR, Karaoglu K, Mavlyutov TA, Ruoho AE.

Chembiochem. 2012 Oct 15;13(15):2277-89. doi: 10.1002/cbic.201200427. Epub 2012 Sep 23.

13.

Tandem photoaffinity labeling-bioorthogonal conjugation in medicinal chemistry.

Lapinsky DJ.

Bioorg Med Chem. 2012 Nov 1;20(21):6237-47. doi: 10.1016/j.bmc.2012.09.010. Epub 2012 Sep 13. Review.

PMID:
23026086
14.

Development of bifunctional photoactivatable benzophenone probes and their application to glycoside substrates.

Qvit N, Monderer-Rothkoff G, Ido A, Shalev DE, Amster-Choder O, Gilon C.

Biopolymers. 2008;90(4):526-36. doi: 10.1002/bip.21010.

PMID:
18459171
15.

Processing of Notch and amyloid precursor protein by gamma-secretase is spatially distinct.

Tarassishin L, Yin YI, Bassit B, Li YM.

Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17050-5. Epub 2004 Nov 24.

16.

Aspartyl protease inhibitor pepstatin binds to the presenilins of Alzheimer's disease.

Evin G, Sharples RA, Weidemann A, Reinhard FB, Carbone V, Culvenor JG, Holsinger RM, Sernee MF, Beyreuther K, Masters CL.

Biochemistry. 2001 Jul 27;40(28):8359-68.

PMID:
11444983
17.

Photoaffinity labeling and its application in structural biology.

Vodovozova EL.

Biochemistry (Mosc). 2007 Jan;72(1):1-20. Review.

PMID:
17309432
18.

The initial substrate-binding site of gamma-secretase is located on presenilin near the active site.

Kornilova AY, Bihel F, Das C, Wolfe MS.

Proc Natl Acad Sci U S A. 2005 Mar 1;102(9):3230-5. Epub 2005 Feb 18.

19.

Distinct pharmacological effects of inhibitors of signal peptide peptidase and gamma-secretase.

Sato T, Ananda K, Cheng CI, Suh EJ, Narayanan S, Wolfe MS.

J Biol Chem. 2008 Nov 28;283(48):33287-95. doi: 10.1074/jbc.M805670200. Epub 2008 Oct 1.

20.

gamma-Secretase substrate selectivity can be modulated directly via interaction with a nucleotide-binding site.

Fraering PC, Ye W, LaVoie MJ, Ostaszewski BL, Selkoe DJ, Wolfe MS.

J Biol Chem. 2005 Dec 23;280(51):41987-96. Epub 2005 Oct 19.

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