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Results: 1 to 20 of 156

1.

An over-oxidized form of superoxide dismutase found in sporadic amyotrophic lateral sclerosis with bulbar onset shares a toxic mechanism with mutant SOD1.

Guareschi S, Cova E, Cereda C, Ceroni M, Donetti E, Bosco DA, Trotti D, Pasinelli P.

Proc Natl Acad Sci U S A. 2012 Mar 27;109(13):5074-9. doi: 10.1073/pnas.1115402109. Epub 2012 Mar 13.

PMID:
22416121
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Oxidized/misfolded superoxide dismutase-1: the cause of all amyotrophic lateral sclerosis?

Kabashi E, Valdmanis PN, Dion P, Rouleau GA.

Ann Neurol. 2007 Dec;62(6):553-9. Review.

PMID:
18074357
[PubMed - indexed for MEDLINE]
3.

ALS-linked mutant SOD1 damages mitochondria by promoting conformational changes in Bcl-2.

Pedrini S, Sau D, Guareschi S, Bogush M, Brown RH Jr, Naniche N, Kia A, Trotti D, Pasinelli P.

Hum Mol Genet. 2010 Aug 1;19(15):2974-86. doi: 10.1093/hmg/ddq202. Epub 2010 May 11.

PMID:
20460269
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Human Cu/Zn superoxide dismutase (SOD1) overexpression in mice causes mitochondrial vacuolization, axonal degeneration, and premature motoneuron death and accelerates motoneuron disease in mice expressing a familial amyotrophic lateral sclerosis mutant SOD1.

Jaarsma D, Haasdijk ED, Grashorn JA, Hawkins R, van Duijn W, Verspaget HW, London J, Holstege JC.

Neurobiol Dis. 2000 Dec;7(6 Pt B):623-43.

PMID:
11114261
[PubMed - indexed for MEDLINE]
5.

Wild-type superoxide dismutase acquires binding and toxic properties of ALS-linked mutant forms through oxidation.

Ezzi SA, Urushitani M, Julien JP.

J Neurochem. 2007 Jul;102(1):170-8. Epub 2007 Mar 29.

PMID:
17394546
[PubMed - indexed for MEDLINE]
6.

Structural instability and Cu-dependent pro-oxidant activity acquired by the apo form of mutant SOD1 associated with amyotrophic lateral sclerosis.

Kitamura F, Fujimaki N, Okita W, Hiramatsu H, Takeuchi H.

Biochemistry. 2011 May 24;50(20):4242-50. doi: 10.1021/bi200338h. Epub 2011 May 2.

PMID:
21506602
[PubMed - indexed for MEDLINE]
7.

Mutant SOD1 instability: implications for toxicity in amyotrophic lateral sclerosis.

Tiwari A, Hayward LJ.

Neurodegener Dis. 2005;2(3-4):115-27. Review.

PMID:
16909016
[PubMed - indexed for MEDLINE]
8.

Motor neuron-astrocyte interactions and levels of Cu,Zn superoxide dismutase in sporadic amyotrophic lateral sclerosis.

O'Reilly SA, Roedica J, Nagy D, Hallewell RA, Alderson K, Marklund SL, Kuby J, Kushner PD.

Exp Neurol. 1995 Feb;131(2):203-10.

PMID:
7895821
[PubMed - indexed for MEDLINE]
9.

Interaction between familial amyotrophic lateral sclerosis (ALS)-linked SOD1 mutants and the dynein complex.

Zhang F, Ström AL, Fukada K, Lee S, Hayward LJ, Zhu H.

J Biol Chem. 2007 Jun 1;282(22):16691-9. Epub 2007 Apr 2.

PMID:
17403682
[PubMed - indexed for MEDLINE]
Free Article
10.

Mitochondrial damage revealed by immunoselection for ALS-linked misfolded SOD1.

Pickles S, Destroismaisons L, Peyrard SL, Cadot S, Rouleau GA, Brown RH Jr, Julien JP, Arbour N, Vande Velde C.

Hum Mol Genet. 2013 Oct 1;22(19):3947-59. doi: 10.1093/hmg/ddt249. Epub 2013 Jun 4.

PMID:
23736301
[PubMed - indexed for MEDLINE]
11.

Conversion to the amyotrophic lateral sclerosis phenotype is associated with intermolecular linked insoluble aggregates of SOD1 in mitochondria.

Deng HX, Shi Y, Furukawa Y, Zhai H, Fu R, Liu E, Gorrie GH, Khan MS, Hung WY, Bigio EH, Lukas T, Dal Canto MC, O'Halloran TV, Siddique T.

Proc Natl Acad Sci U S A. 2006 May 2;103(18):7142-7. Epub 2006 Apr 24.

PMID:
16636275
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

An emerging role for misfolded wild-type SOD1 in sporadic ALS pathogenesis.

Rotunno MS, Bosco DA.

Front Cell Neurosci. 2013 Dec 16;7:253. doi: 10.3389/fncel.2013.00253. Review.

PMID:
24379756
[PubMed]
Free PMC Article
13.

Familial ALS-superoxide dismutases associate with mitochondria and shift their redox potentials.

Ferri A, Cozzolino M, Crosio C, Nencini M, Casciati A, Gralla EB, Rotilio G, Valentine JS, Carrì MT.

Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13860-5. Epub 2006 Aug 30.

PMID:
16945901
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

An examination of wild-type SOD1 in modulating the toxicity and aggregation of ALS-associated mutant SOD1.

Prudencio M, Durazo A, Whitelegge JP, Borchelt DR.

Hum Mol Genet. 2010 Dec 15;19(24):4774-89. doi: 10.1093/hmg/ddq408. Epub 2010 Sep 24.

PMID:
20871097
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Structural changes to monomeric CuZn superoxide dismutase caused by the familial amyotrophic lateral sclerosis-associated mutation A4V.

Schmidlin T, Kennedy BK, Daggett V.

Biophys J. 2009 Sep 16;97(6):1709-18. doi: 10.1016/j.bpj.2009.06.043.

PMID:
19751676
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Selective association of misfolded ALS-linked mutant SOD1 with the cytoplasmic face of mitochondria.

Vande Velde C, Miller TM, Cashman NR, Cleveland DW.

Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):4022-7. doi: 10.1073/pnas.0712209105. Epub 2008 Feb 22.

PMID:
18296640
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Mitochondrial dysfunction in familial amyotrophic lateral sclerosis.

Faes L, Callewaert G.

J Bioenerg Biomembr. 2011 Dec;43(6):587-92. doi: 10.1007/s10863-011-9393-0. Review.

PMID:
22072073
[PubMed - indexed for MEDLINE]
18.

Aggregation of copper-zinc superoxide dismutase in familial and sporadic ALS.

Chattopadhyay M, Valentine JS.

Antioxid Redox Signal. 2009 Jul;11(7):1603-14. doi: 10.1089/ARS.2009.2536. Review.

PMID:
19271992
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Familial amyotrophic lateral sclerosis-linked SOD1 mutants perturb fast axonal transport to reduce axonal mitochondria content.

De Vos KJ, Chapman AL, Tennant ME, Manser C, Tudor EL, Lau KF, Brownlees J, Ackerley S, Shaw PJ, McLoughlin DM, Shaw CE, Leigh PN, Miller CC, Grierson AJ.

Hum Mol Genet. 2007 Nov 15;16(22):2720-8. Epub 2007 Aug 28.

PMID:
17725983
[PubMed - indexed for MEDLINE]
Free Article
20.

Redox system expression in the motor neurons in amyotrophic lateral sclerosis (ALS): immunohistochemical studies on sporadic ALS, superoxide dismutase 1 (SOD1)-mutated familial ALS, and SOD1-mutated ALS animal models.

Kato S, Kato M, Abe Y, Matsumura T, Nishino T, Aoki M, Itoyama Y, Asayama K, Awaya A, Hirano A, Ohama E.

Acta Neuropathol. 2005 Aug;110(2):101-12. Epub 2005 Jun 28.

PMID:
15983830
[PubMed - indexed for MEDLINE]

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