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Items: 1 to 20 of 125

1.

Human longevity and variation in GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: cross sectional and longitudinal studies.

Soerensen M, Dato S, Tan Q, Thinggaard M, Kleindorp R, Beekman M, Jacobsen R, Suchiman HE, de Craen AJ, Westendorp RG, Schreiber S, Stevnsner T, Bohr VA, Slagboom PE, Nebel A, Vaupel JW, Christensen K, McGue M, Christiansen L.

Exp Gerontol. 2012 May;47(5):379-87. doi: 10.1016/j.exger.2012.02.010. Epub 2012 Mar 3.

2.

Genetic variation and human longevity.

Soerensen M.

Dan Med J. 2012 May;59(5):B4454.

PMID:
22549493
3.

Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways.

Deelen J, Uh HW, Monajemi R, van Heemst D, Thijssen PE, Böhringer S, van den Akker EB, de Craen AJ, Rivadeneira F, Uitterlinden AG, Westendorp RG, Goeman JJ, Slagboom PE, Houwing-Duistermaat JJ, Beekman M.

Age (Dordr). 2013 Feb;35(1):235-49. doi: 10.1007/s11357-011-9340-3. Epub 2011 Nov 24.

4.
5.

Replication of an association of variation in the FOXO3A gene with human longevity using both case-control and longitudinal data.

Soerensen M, Dato S, Christensen K, McGue M, Stevnsner T, Bohr VA, Christiansen L.

Aging Cell. 2010 Dec;9(6):1010-7. doi: 10.1111/j.1474-9726.2010.00627.x. Epub 2010 Oct 21.

6.

Association analyses of insulin signaling pathway gene polymorphisms with healthy aging and longevity in Americans of Japanese ancestry.

Morris BJ, Donlon TA, He Q, Grove JS, Masaki KH, Elliott A, Willcox DC, Willcox BJ.

J Gerontol A Biol Sci Med Sci. 2014 Mar;69(3):270-3. doi: 10.1093/gerona/glt082. Epub 2013 Jun 14.

7.

Evidence from case-control and longitudinal studies supports associations of genetic variation in APOE, CETP, and IL6 with human longevity.

Soerensen M, Dato S, Tan Q, Thinggaard M, Kleindorp R, Beekman M, Suchiman HE, Jacobsen R, McGue M, Stevnsner T, Bohr VA, de Craen AJ, Westendorp RG, Schreiber S, Slagboom PE, Nebel A, Vaupel JW, Christensen K, Christiansen L.

Age (Dordr). 2013 Apr;35(2):487-500. doi: 10.1007/s11357-011-9373-7. Epub 2012 Jan 12.

8.

Reduced insulin/IGF-1 signalling and human longevity.

van Heemst D, Beekman M, Mooijaart SP, Heijmans BT, Brandt BW, Zwaan BJ, Slagboom PE, Westendorp RG.

Aging Cell. 2005 Apr;4(2):79-85.

9.

Absence of association between SNPs in the promoter region of the insulin-like growth factor 1 (IGF-1) gene and longevity in the Han Chinese population.

Xie L, Gong YY, Lian SG, Yang J, Yang Y, Gao SJ, Xu LY, Zhang YP.

Exp Gerontol. 2008 Oct;43(10):962-5. doi: 10.1016/j.exger.2008.08.004. Epub 2008 Aug 12.

PMID:
18761080
10.

Association analysis between longevity in the Japanese population and polymorphic variants of genes involved in insulin and insulin-like growth factor 1 signaling pathways.

Kojima T, Kamei H, Aizu T, Arai Y, Takayama M, Nakazawa S, Ebihara Y, Inagaki H, Masui Y, Gondo Y, Sakaki Y, Hirose N.

Exp Gerontol. 2004 Nov-Dec;39(11-12):1595-8.

PMID:
15582274
11.

No Association between Variation in Longevity Candidate Genes and Aging-related Phenotypes in Oldest-old Danes.

Soerensen M, Nygaard M, Debrabant B, Mengel-From J, Dato S, Thinggaard M, Christensen K, Christiansen L.

Exp Gerontol. 2016 Jun 1;78:57-61. doi: 10.1016/j.exger.2016.03.001. Epub 2016 Mar 3.

PMID:
26946122
12.

Human longevity and variation in DNA damage response and repair: study of the contribution of sub-processes using competitive gene-set analysis.

Debrabant B, Soerensen M, Flachsbart F, Dato S, Mengel-From J, Stevnsner T, Bohr VA, Kruse TA, Schreiber S, Nebel A, Christensen K, Tan Q, Christiansen L.

Eur J Hum Genet. 2014 Sep;22(9):1131-6. doi: 10.1038/ejhg.2013.299. Epub 2014 Feb 12.

13.

Genetic variation in insulin/IGF-1 signaling pathways and longevity.

Ziv E, Hu D.

Ageing Res Rev. 2011 Apr;10(2):201-4. doi: 10.1016/j.arr.2010.09.002. Epub 2010 Sep 22. Review.

PMID:
20868776
14.

Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity.

Pawlikowska L, Hu D, Huntsman S, Sung A, Chu C, Chen J, Joyner AH, Schork NJ, Hsueh WC, Reiner AP, Psaty BM, Atzmon G, Barzilai N, Cummings SR, Browner WS, Kwok PY, Ziv E; Study of Osteoporotic Fractures.

Aging Cell. 2009 Aug;8(4):460-72. doi: 10.1111/j.1474-9726.2009.00493.x. Epub 2009 May 31.

15.

Insulin-like growth factor-1- and interleukin-6-related gene variation and risk of multiple myeloma.

Birmann BM, Tamimi RM, Giovannucci E, Rosner B, Hunter DJ, Kraft P, Mitsiades C, Anderson KC, Colditz GA.

Cancer Epidemiol Biomarkers Prev. 2009 Jan;18(1):282-8. doi: 10.1158/1055-9965.EPI-08-0778.

16.

Common polymorphisms in the GH/IGF-1 axis contribute to growth in extremely tall subjects.

Hendriks AE, Brown MR, Boot AM, Oostra BA, de Jong FH, Drop SL, Parks JS.

Growth Horm IGF Res. 2011 Dec;21(6):318-24. doi: 10.1016/j.ghir.2011.08.001. Epub 2011 Sep 25.

PMID:
21944866
17.

Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited.

Deelen J, Beekman M, Uh HW, Helmer Q, Kuningas M, Christiansen L, Kremer D, van der Breggen R, Suchiman HE, Lakenberg N, van den Akker EB, Passtoors WM, Tiemeier H, van Heemst D, de Craen AJ, Rivadeneira F, de Geus EJ, Perola M, van der Ouderaa FJ, Gunn DA, Boomsma DI, Uitterlinden AG, Christensen K, van Duijn CM, Heijmans BT, Houwing-Duistermaat JJ, Westendorp RG, Slagboom PE.

Aging Cell. 2011 Aug;10(4):686-98. doi: 10.1111/j.1474-9726.2011.00705.x. Epub 2011 May 6.

18.

Role of the IGF/insulin system in longevity.

Mari D.

Minerva Endocrinol. 2011 Sep;36(3):181-5.

PMID:
22019749
19.

Variants in the GH-IGF axis confer susceptibility to lung cancer.

Rudd MF, Webb EL, Matakidou A, Sellick GS, Williams RD, Bridle H, Eisen T, Houlston RS; GELCAPS Consortium.

Genome Res. 2006 Jun;16(6):693-701.

20.

The paradox of the insulin/IGF-1 signaling pathway in longevity.

Rincon M, Muzumdar R, Atzmon G, Barzilai N.

Mech Ageing Dev. 2004 Jun;125(6):397-403. Review.

PMID:
15272501
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