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Results: 1 to 20 of 128

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1.

Lipophilic analogs of zoledronate and risedronate inhibit Plasmodium geranylgeranyl diphosphate synthase (GGPPS) and exhibit potent antimalarial activity.

No JH, de Macedo Dossin F, Zhang Y, Liu YL, Zhu W, Feng X, Yoo JA, Lee E, Wang K, Hui R, Freitas-Junior LH, Oldfield E.

Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4058-63. doi: 10.1073/pnas.1118215109. Epub 2012 Mar 5.

2.

Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation.

Zhang Y, Cao R, Yin F, Hudock MP, Guo RT, Krysiak K, Mukherjee S, Gao YG, Robinson H, Song Y, No JH, Bergan K, Leon A, Cass L, Goddard A, Chang TK, Lin FY, Van Beek E, Papapoulos S, Wang AH, Kubo T, Ochi M, Mukkamala D, Oldfield E.

J Am Chem Soc. 2009 Apr 15;131(14):5153-62. doi: 10.1021/ja808285e.

3.

Lipophilic bisphosphonates are potent inhibitors of Plasmodium liver-stage growth.

Singh AP, Zhang Y, No JH, Docampo R, Nussenzweig V, Oldfield E.

Antimicrob Agents Chemother. 2010 Jul;54(7):2987-93. doi: 10.1128/AAC.00198-10. Epub 2010 May 10.

4.

Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation.

K-M Chen C, Hudock MP, Zhang Y, Guo RT, Cao R, No JH, Liang PH, Ko TP, Chang TH, Chang SC, Song Y, Axelson J, Kumar A, Wang AH, Oldfield E.

J Med Chem. 2008 Sep 25;51(18):5594-607. doi: 10.1021/jm800325y.

5.

Nitrogen-containing bisphosphonates can inhibit angiogenesis in vivo without the involvement of farnesyl pyrophosphate synthase.

Stresing V, Fournier PG, Bellahcène A, Benzaïd I, Mönkkönen H, Colombel M, Ebetino FH, Castronovo V, Clézardin P.

Bone. 2011 Feb;48(2):259-66. doi: 10.1016/j.bone.2010.09.035. Epub 2010 Oct 20.

PMID:
20920623
6.

Structures of a potent phenylalkyl bisphosphonate inhibitor bound to farnesyl and geranylgeranyl diphosphate synthases.

Cao R, Chen CK, Guo RT, Wang AH, Oldfield E.

Proteins. 2008 Nov 1;73(2):431-9. doi: 10.1002/prot.22066.

7.

In vitro and in vivo antiplasmodial activities of risedronate and its interference with protein prenylation in Plasmodium falciparum.

Jordão FM, Saito AY, Miguel DC, de Jesus Peres V, Kimura EA, Katzin AM.

Antimicrob Agents Chemother. 2011 May;55(5):2026-31. doi: 10.1128/AAC.01820-10. Epub 2011 Feb 28.

8.

Effects of bisphosphonates on the growth of Entamoeba histolytica and Plasmodium species in vitro and in vivo.

Ghosh S, Chan JM, Lea CR, Meints GA, Lewis JC, Tovian ZS, Flessner RM, Loftus TC, Bruchhaus I, Kendrick H, Croft SL, Kemp RG, Kobayashi S, Nozaki T, Oldfield E.

J Med Chem. 2004 Jan 1;47(1):175-87.

PMID:
14695831
9.

The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs.

Kavanagh KL, Guo K, Dunford JE, Wu X, Knapp S, Ebetino FH, Rogers MJ, Russell RG, Oppermann U.

Proc Natl Acad Sci U S A. 2006 May 16;103(20):7829-34. Epub 2006 May 9.

10.

Synthesis and biological evaluation of a series of aromatic bisphosphonates.

Barney RJ, Wasko BM, Dudakovic A, Hohl RJ, Wiemer DF.

Bioorg Med Chem. 2010 Oct 15;18(20):7212-20. doi: 10.1016/j.bmc.2010.08.036. Epub 2010 Aug 19.

PMID:
20832326
11.

Enthalpy versus entropy-driven binding of bisphosphonates to farnesyl diphosphate synthase.

Yin F, Cao R, Goddard A, Zhang Y, Oldfield E.

J Am Chem Soc. 2006 Mar 22;128(11):3524-5.

PMID:
16536518
12.

Evaluation of the activities of pyrimethamine analogs against Plasmodium vivax and Plasmodium falciparum dihydrofolate reductase-thymidylate synthase using in vitro enzyme inhibition and bacterial complementation assays.

Bunyarataphan S, Leartsakulpanich U, Taweechai S, Tarnchompoo B, Kamchonwongpaisan S, Yuthavong Y.

Antimicrob Agents Chemother. 2006 Nov;50(11):3631-7. Epub 2006 Sep 5.

13.

Pharmacophoric studies of in vitro inhibition of Plasmodium falciparum growth.

Hariharan S.

Indian J Biochem Biophys. 2012 Apr;49(2):101-8.

PMID:
22650007
14.

Digeranyl bisphosphonate inhibits geranylgeranyl pyrophosphate synthase.

Wiemer AJ, Tong H, Swanson KM, Hohl RJ.

Biochem Biophys Res Commun. 2007 Feb 23;353(4):921-5. Epub 2006 Dec 21.

PMID:
17208200
15.

Farnesyl pyrophosphate synthase enantiospecificity with a chiral risedronate analog, [6,7-dihydro-5H-cyclopenta[c]pyridin-7-yl(hydroxy)methylene]bis(phosphonic acid) (NE-10501): Synthetic, structural, and modeling studies.

Deprèle S, Kashemirov BA, Hogan JM, Ebetino FH, Barnett BL, Evdokimov A, McKenna CE.

Bioorg Med Chem Lett. 2008 May 1;18(9):2878-82. doi: 10.1016/j.bmcl.2008.03.088. Epub 2008 Apr 8.

PMID:
18434151
16.

Development of benzophenone-based farnesyltransferase inhibitors as novel antimalarials.

Kohring K, Wiesner J, Altenkämper M, Sakowski J, Silber K, Hillebrecht A, Haebel P, Dahse HM, Ortmann R, Jomaa H, Klebe G, Schlitzer M.

ChemMedChem. 2008 Aug;3(8):1217-31. doi: 10.1002/cmdc.200800043.

PMID:
18470859
17.

Cloning and characterization of bifunctional enzyme farnesyl diphosphate/geranylgeranyl diphosphate synthase from Plasmodium falciparum.

Jordão FM, Gabriel HB, Alves JM, Angeli CB, Bifano TD, Breda A, de Azevedo MF, Basso LA, Wunderlich G, Kimura EA, Katzin AM.

Malar J. 2013 Jun 4;12:184. doi: 10.1186/1475-2875-12-184.

18.

A class of potent antimalarials and their specific accumulation in infected erythrocytes.

Wengelnik K, Vidal V, Ancelin ML, Cathiard AM, Morgat JL, Kocken CH, Calas M, Herrera S, Thomas AW, Vial HJ.

Science. 2002 Feb 15;295(5558):1311-4.

19.

In Silico screening on the three-dimensional model of the Plasmodium vivax SUB1 protease leads to the validation of a novel anti-parasite compound.

Bouillon A, Giganti D, Benedet C, Gorgette O, Pêtres S, Crublet E, Girard-Blanc C, Witkowski B, Ménard D, Nilges M, Mercereau-Puijalon O, Stoven V, Barale JC.

J Biol Chem. 2013 Jun 21;288(25):18561-73. doi: 10.1074/jbc.M113.456764. Epub 2013 May 7.

20.

Antimalarial activity of potential inhibitors of Plasmodium falciparum lactate dehydrogenase enzyme selected by docking studies.

Penna-Coutinho J, Cortopassi WA, Oliveira AA, França TC, Krettli AU.

PLoS One. 2011;6(7):e21237. doi: 10.1371/journal.pone.0021237. Epub 2011 Jul 14.

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