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Items: 1 to 20 of 97

1.

Fbxw7α- and GSK3-mediated degradation of p100 is a pro-survival mechanism in multiple myeloma.

Busino L, Millman SE, Scotto L, Kyratsous CA, Basrur V, O'Connor O, Hoffmann A, Elenitoba-Johnson KS, Pagano M.

Nat Cell Biol. 2012 Mar 4;14(4):375-85. doi: 10.1038/ncb2463.

2.

SCF-mediated degradation of p100 (NF-κB2): mechanisms and relevance in multiple myeloma.

Busino L, Millman SE, Pagano M.

Sci Signal. 2012 Dec 4;5(253):pt14. doi: 10.1126/scisignal.2003408. Review.

3.

Proteomic screen reveals Fbw7 as a modulator of the NF-κB pathway.

Arabi A, Ullah K, Branca RM, Johansson J, Bandarra D, Haneklaus M, Fu J, Ariës I, Nilsson P, Den Boer ML, Pokrovskaja K, Grandér D, Xiao G, Rocha S, Lehtiö J, Sangfelt O.

Nat Commun. 2012;3:976. doi: 10.1038/ncomms1975.

4.

Glycogen synthase kinase 3 regulates expression of nuclear factor-erythroid-2 related transcription factor-1 (Nrf1) and inhibits pro-survival function of Nrf1.

Biswas M, Kwong EK, Park E, Nagra P, Chan JY.

Exp Cell Res. 2013 Aug 1;319(13):1922-31. doi: 10.1016/j.yexcr.2013.04.013. Epub 2013 Apr 23.

5.

SCF(Fbw7) modulates the NFkB signaling pathway by targeting NFkB2 for ubiquitination and destruction.

Fukushima H, Matsumoto A, Inuzuka H, Zhai B, Lau AW, Wan L, Gao D, Shaik S, Yuan M, Gygi SP, Jimi E, Asara JM, Nakayama K, Nakayama KI, Wei W.

Cell Rep. 2012 May 31;1(5):434-43.

6.

Stringent Control of NFE2L3 (Nuclear Factor, Erythroid 2-Like 3; NRF3) Protein Degradation by FBW7 (F-box/WD Repeat-containing Protein 7) and Glycogen Synthase Kinase 3 (GSK3).

Kannan MB, Dodard-Friedman I, Blank V.

J Biol Chem. 2015 Oct 23;290(43):26292-302. doi: 10.1074/jbc.M115.666446. Epub 2015 Aug 25.

PMID:
26306035
7.

Rictor Undergoes Glycogen Synthase Kinase 3 (GSK3)-dependent, FBXW7-mediated Ubiquitination and Proteasomal Degradation.

Koo J, Wu X, Mao Z, Khuri FR, Sun SY.

J Biol Chem. 2015 May 29;290(22):14120-9. doi: 10.1074/jbc.M114.633057. Epub 2015 Apr 20.

PMID:
25897075
8.

The Transitional Endoplasmic Reticulum ATPase p97 Regulates the Alternative Nuclear Factor NF-κB Signaling via Partial Degradation of the NF-κB Subunit p100.

Zhang Z, Wang Y, Li C, Shi Z, Hao Q, Wang W, Song X, Zhao Y, Jiao S, Zhou Z.

J Biol Chem. 2015 Aug 7;290(32):19558-68. doi: 10.1074/jbc.M114.630061. Epub 2015 Jun 25.

PMID:
26112410
9.

BCL-3 degradation involves its polyubiquitination through a FBW7-independent pathway and its binding to the proteasome subunit PSMB1.

Keutgens A, Zhang X, Shostak K, Robert I, Olivier S, Vanderplasschen A, Chapelle JP, Viatour P, Merville MP, Bex F, Gothot A, Chariot A.

J Biol Chem. 2010 Aug 13;285(33):25831-40. doi: 10.1074/jbc.M110.112128. Epub 2010 Jun 17.

10.

Fbxw7 acts as an E3 ubiquitin ligase that targets c-Myb for nemo-like kinase (NLK)-induced degradation.

Kanei-Ishii C, Nomura T, Takagi T, Watanabe N, Nakayama KI, Ishii S.

J Biol Chem. 2008 Nov 7;283(45):30540-8. doi: 10.1074/jbc.M804340200. Epub 2008 Sep 2.

11.

FBXW7 modulates cellular stress response and metastatic potential through ​HSF1 post-translational modification.

Kourtis N, Moubarak RS, Aranda-Orgilles B, Lui K, Aydin IT, Trimarchi T, Darvishian F, Salvaggio C, Zhong J, Bhatt K, Chen EI, Celebi JT, Lazaris C, Tsirigos A, Osman I, Hernando E, Aifantis I.

Nat Cell Biol. 2015 Mar;17(3):322-32.

12.

Negative regulation of NF-κB activity by brain-specific TRIpartite Motif protein 9.

Shi M, Cho H, Inn KS, Yang A, Zhao Z, Liang Q, Versteeg GA, Amini-Bavil-Olyaee S, Wong LY, Zlokovic BV, Park HS, García-Sastre A, Jung JU.

Nat Commun. 2014 Sep 5;5:4820. doi: 10.1038/ncomms5820.

14.

mTOR Complex 2 Stabilizes Mcl-1 Protein by Suppressing Its Glycogen Synthase Kinase 3-Dependent and SCF-FBXW7-Mediated Degradation.

Koo J, Yue P, Deng X, Khuri FR, Sun SY.

Mol Cell Biol. 2015 Jul;35(13):2344-55. doi: 10.1128/MCB.01525-14. Epub 2015 Apr 27.

15.

GSK3-SCF(FBXW7) targets JunB for degradation in G2 to preserve chromatid cohesion before anaphase.

Pérez-Benavente B, García JL, Rodríguez MS, Pineda-Lucena A, Piechaczyk M, Font de Mora J, Farràs R.

Oncogene. 2013 Apr 25;32(17):2189-99. doi: 10.1038/onc.2012.235. Epub 2012 Jun 18.

PMID:
22710716
16.

NF-kappaB signalling proteins p50/p105, p52/p100, RelA, and IKKepsilon are over-expressed in oesophageal squamous cell carcinomas.

Kang MR, Kim MS, Kim SS, Ahn CH, Yoo NJ, Lee SH.

Pathology. 2009;41(7):622-5. doi: 10.3109/00313020903257756.

PMID:
20001340
17.

E3 ubiquitin ligase Fbw7 negatively regulates granulocytic differentiation by targeting G-CSFR for degradation.

Lochab S, Pal P, Kapoor I, Kanaujiya JK, Sanyal S, Behre G, Trivedi AK.

Biochim Biophys Acta. 2013 Dec;1833(12):2639-52. doi: 10.1016/j.bbamcr.2013.06.018. Epub 2013 Jun 29.

18.

UV-induced degradation of securin is mediated by SKP1-CUL1-beta TrCP E3 ubiquitin ligase.

Limón-Mortés MC, Mora-Santos M, Espina A, Pintor-Toro JA, López-Román A, Tortolero M, Romero F.

J Cell Sci. 2008 Jun 1;121(11):1825-31. doi: 10.1242/jcs.020552. Epub 2008 May 6.

19.

FBW7 regulates endothelial functions by targeting KLF2 for ubiquitination and degradation.

Wang R, Wang Y, Liu N, Ren C, Jiang C, Zhang K, Yu S, Chen Y, Tang H, Deng Q, Fu C, Wang Y, Li R, Liu M, Pan W, Wang P.

Cell Res. 2013 Jun;23(6):803-19. doi: 10.1038/cr.2013.42. Epub 2013 Mar 19.

20.

Fbw7 promotes ubiquitin-dependent degradation of c-Myb: involvement of GSK3-mediated phosphorylation of Thr-572 in mouse c-Myb.

Kitagawa K, Hiramatsu Y, Uchida C, Isobe T, Hattori T, Oda T, Shibata K, Nakamura S, Kikuchi A, Kitagawa M.

Oncogene. 2009 Jun 25;28(25):2393-405. doi: 10.1038/onc.2009.111. Epub 2009 May 4.

PMID:
19421138
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