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Items: 1 to 20 of 117

1.

Neutral sphingomyelinase 2 deficiency increases hyaluronan synthesis by up-regulation of Hyaluronan synthase 2 through decreased ceramide production and activation of Akt.

Qin J, Berdyshev E, Poirer C, Schwartz NB, Dawson G.

J Biol Chem. 2012 Apr 20;287(17):13620-32. doi: 10.1074/jbc.M111.304857. Epub 2012 Mar 1.

2.

The hyaluronic acid inhibitor 4-methylumbelliferone is an NSMase2 activator-role of Ceramide in MU anti-tumor activity.

Qin J, Kilkus J, Dawson G.

Biochim Biophys Acta. 2016 Feb;1861(2):78-90. doi: 10.1016/j.bbalip.2015.11.001. Epub 2015 Nov 5.

PMID:
26548718
3.

Hyaluronan synthase-2 upregulation protects smpd3-deficient fibroblasts against cell death induced by nutrient deprivation, but not against apoptosis evoked by oxidized LDL.

Garoby-Salom S, Rouahi M, Mucher E, Auge N, Salvayre R, Negre-Salvayre A.

Redox Biol. 2015;4:118-26. doi: 10.1016/j.redox.2014.12.004. Epub 2014 Dec 16.

4.

Bone morphogenic protein (BMP) signaling up-regulates neutral sphingomyelinase 2 to suppress chondrocyte maturation via the Akt protein signaling pathway as a negative feedback mechanism.

Kakoi H, Maeda S, Shinohara N, Matsuyama K, Imamura K, Kawamura I, Nagano S, Setoguchi T, Yokouchi M, Ishidou Y, Komiya S.

J Biol Chem. 2014 Mar 21;289(12):8135-50. doi: 10.1074/jbc.M113.509331. Epub 2014 Feb 6.

5.

Melanoma cell-derived factors stimulate hyaluronan synthesis in dermal fibroblasts by upregulating HAS2 through PDGFR-PI3K-AKT and p38 signaling.

Pasonen-Seppänen S, Takabe P, Edward M, Rauhala L, Rilla K, Tammi M, Tammi R.

Histochem Cell Biol. 2012 Dec;138(6):895-911. doi: 10.1007/s00418-012-1000-x. Epub 2012 Jul 24.

PMID:
22825838
6.

Evidence for coordination of lysosomal (ASMase) and plasma membrane (NSMase2) forms of sphingomyelinase from mutant mice.

Qin J, Dawson G.

FEBS Lett. 2012 Nov 16;586(22):4002-9. doi: 10.1016/j.febslet.2012.09.039. Epub 2012 Oct 6.

7.

Methyl-beta-cyclodextrin suppresses hyaluronan synthesis by down-regulation of hyaluronan synthase 2 through inhibition of Akt.

Kultti A, Kärnä R, Rilla K, Nurminen P, Koli E, Makkonen KM, Si J, Tammi MI, Tammi RH.

J Biol Chem. 2010 Jul 23;285(30):22901-10. doi: 10.1074/jbc.M109.088435. Epub 2010 May 25.

8.

Biochemical properties of mammalian neutral sphingomyelinase 2 and its role in sphingolipid metabolism.

Marchesini N, Luberto C, Hannun YA.

J Biol Chem. 2003 Apr 18;278(16):13775-83. Epub 2003 Feb 3.

9.

Neutral sphingomyelinase 2 deficiency is associated with lung anomalies similar to emphysema.

Poirier C, Berdyshev EV, Dimitropoulou C, Bogatcheva NV, Biddinger PW, Verin AD.

Mamm Genome. 2012 Dec;23(11-12):758-63. doi: 10.1007/s00335-012-9419-x. Epub 2012 Sep 4.

10.

Chondroitin sulfate increases hyaluronan production by human synoviocytes through differential regulation of hyaluronan synthases: Role of p38 and Akt.

David-Raoudi M, Deschrevel B, Leclercq S, Galéra P, Boumediene K, Pujol JP.

Arthritis Rheum. 2009 Mar;60(3):760-70. doi: 10.1002/art.24302.

11.

Differential regulation of ceramide in lipid-rich microdomains (rafts): antagonistic role of palmitoyl:protein thioesterase and neutral sphingomyelinase 2.

Goswami R, Ahmed M, Kilkus J, Han T, Dawson SA, Dawson G.

J Neurosci Res. 2005 Jul 15;81(2):208-17.

PMID:
15929065
12.

A signaling cascade mediated by ceramide, src and PDGFRβ coordinates the activation of the redox-sensitive neutral sphingomyelinase-2 and sphingosine kinase-1.

Cinq-Frais C, Coatrieux C, Grazide MH, Hannun YA, Nègre-Salvayre A, Salvayre R, Augé N.

Biochim Biophys Acta. 2013 Aug;1831(8):1344-56. doi: 10.1016/j.bbalip.2013.04.014. Epub 2013 May 4.

PMID:
23651497
13.

Unrestrained mammalian target of rapamycin complexes 1 and 2 increase expression of phosphatase and tensin homolog deleted on chromosome 10 to regulate phosphorylation of Akt kinase.

Das F, Ghosh-Choudhury N, Dey N, Mandal CC, Mahimainathan L, Kasinath BS, Abboud HE, Choudhury GG.

J Biol Chem. 2012 Feb 3;287(6):3808-22. doi: 10.1074/jbc.M111.246397. Epub 2011 Dec 19.

14.

Neutral sphingomyelinase-2 mediates growth arrest by retinoic acid through modulation of ribosomal S6 kinase.

Clarke CJ, Mediwala K, Jenkins RW, Sutton CA, Tholanikunnel BG, Hannun YA.

J Biol Chem. 2011 Jun 17;286(24):21565-76. doi: 10.1074/jbc.M110.193375. Epub 2011 May 2.

15.

Regulation of autophagy and its associated cell death by "sphingolipid rheostat": reciprocal role of ceramide and sphingosine 1-phosphate in the mammalian target of rapamycin pathway.

Taniguchi M, Kitatani K, Kondo T, Hashimoto-Nishimura M, Asano S, Hayashi A, Mitsutake S, Igarashi Y, Umehara H, Takeya H, Kigawa J, Okazaki T.

J Biol Chem. 2012 Nov 16;287(47):39898-910. doi: 10.1074/jbc.M112.416552. Epub 2012 Oct 3.

16.

Atorvastatin enhances neurite outgrowth in cortical neurons in vitro via up-regulating the Akt/mTOR and Akt/GSK-3β signaling pathways.

Jin Y, Sui HJ, Dong Y, Ding Q, Qu WH, Yu SX, Jin YX.

Acta Pharmacol Sin. 2012 Jul;33(7):861-72. doi: 10.1038/aps.2012.59. Epub 2012 Jun 18.

17.

Collagen fragments inhibit hyaluronan synthesis in skin fibroblasts in response to ultraviolet B (UVB): new insights into mechanisms of matrix remodeling.

Röck K, Grandoch M, Majora M, Krutmann J, Fischer JW.

J Biol Chem. 2011 May 20;286(20):18268-76. doi: 10.1074/jbc.M110.201665. Epub 2011 Mar 17.

18.

Activation of sphingolipid turnover and chronic generation of ceramide and sphingosine in liver during aging.

Lightle SA, Oakley JI, Nikolova-Karakashian MN.

Mech Ageing Dev. 2000 Dec 1;120(1-3):111-25.

PMID:
11087909
19.

Fibroblast growth factor-2 stimulates directed migration of periodontal ligament cells via PI3K/AKT signaling and CD44/hyaluronan interaction.

Shimabukuro Y, Terashima H, Takedachi M, Maeda K, Nakamura T, Sawada K, Kobashi M, Awata T, Oohara H, Kawahara T, Iwayama T, Hashikawa T, Yanagita M, Yamada S, Murakami S.

J Cell Physiol. 2011 Mar;226(3):809-21. doi: 10.1002/jcp.22406.

PMID:
20857427
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