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Results: 1 to 20 of 210

1.

Disruption of hemochromatosis protein and transferrin receptor 2 causes iron-induced liver injury in mice.

Delima RD, Chua AC, Tirnitz-Parker JE, Gan EK, Croft KD, Graham RM, Olynyk JK, Trinder D.

Hepatology. 2012 Aug;56(2):585-93. doi: 10.1002/hep.25689. Epub 2012 Jun 11.

PMID:
22383097
[PubMed - indexed for MEDLINE]
2.

Iron regulation of hepcidin despite attenuated Smad1,5,8 signaling in mice without transferrin receptor 2 or Hfe.

Corradini E, Rozier M, Meynard D, Odhiambo A, Lin HY, Feng Q, Migas MC, Britton RS, Babitt JL, Fleming RE.

Gastroenterology. 2011 Nov;141(5):1907-14. doi: 10.1053/j.gastro.2011.06.077. Epub 2011 Jul 13.

PMID:
21745449
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload.

Wallace DF, Summerville L, Crampton EM, Frazer DM, Anderson GJ, Subramaniam VN.

Hepatology. 2009 Dec;50(6):1992-2000. doi: 10.1002/hep.23198.

PMID:
19824072
[PubMed - indexed for MEDLINE]
4.

Blunted hepcidin response to inflammation in the absence of Hfe and transferrin receptor 2.

Wallace DF, McDonald CJ, Ostini L, Subramaniam VN.

Blood. 2011 Mar 10;117(10):2960-6. doi: 10.1182/blood-2010-08-303859. Epub 2011 Jan 18.

PMID:
21245482
[PubMed - indexed for MEDLINE]
Free Article
5.

Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice.

Ramos E, Kautz L, Rodriguez R, Hansen M, Gabayan V, Ginzburg Y, Roth MP, Nemeth E, Ganz T.

Hepatology. 2011 Apr;53(4):1333-41. doi: 10.1002/hep.24178.

PMID:
21480335
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Interaction of the hereditary hemochromatosis protein HFE with transferrin receptor 2 is required for transferrin-induced hepcidin expression.

Gao J, Chen J, Kramer M, Tsukamoto H, Zhang AS, Enns CA.

Cell Metab. 2009 Mar;9(3):217-27. doi: 10.1016/j.cmet.2009.01.010.

PMID:
19254567
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Targeted disruption of the hepatic transferrin receptor 2 gene in mice leads to iron overload.

Wallace DF, Summerville L, Subramaniam VN.

Gastroenterology. 2007 Jan;132(1):301-10. Epub 2006 Nov 18.

PMID:
17241880
[PubMed - indexed for MEDLINE]
8.

Transgenic HFE-dependent induction of hepcidin in mice does not require transferrin receptor-2.

Schmidt PJ, Fleming MD.

Am J Hematol. 2012 Jun;87(6):588-95. doi: 10.1002/ajh.23173. Epub 2012 Mar 28.

PMID:
22460705
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

The transferrin receptor modulates Hfe-dependent regulation of hepcidin expression.

Schmidt PJ, Toran PT, Giannetti AM, Bjorkman PJ, Andrews NC.

Cell Metab. 2008 Mar;7(3):205-14. doi: 10.1016/j.cmet.2007.11.016.

PMID:
18316026
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

[Pathophysiology and genetics of classic HFE (type 1) hemochromatosis].

Loréal O, Ropert M, Mosser A, Déhais V, Deugnier Y, David V, Brissot P, Jouanolle AM.

Presse Med. 2007 Sep;36(9 Pt 2):1271-7. Epub 2007 May 22. Review. French.

PMID:
17521857
[PubMed - indexed for MEDLINE]
11.

Iron stores modulate hepatic hepcidin expression by an HFE-independent pathway.

Gehrke SG, Herrmann T, Kulaksiz H, Merle U, Bents K, Kaiser I, Riedel HD, Stremmel W.

Digestion. 2005;72(1):25-32. Epub 2005 Aug 10.

PMID:
16103673
[PubMed - indexed for MEDLINE]
12.

Targeted mutagenesis of the murine transferrin receptor-2 gene produces hemochromatosis.

Fleming RE, Ahmann JR, Migas MC, Waheed A, Koeffler HP, Kawabata H, Britton RS, Bacon BR, Sly WS.

Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10653-8. Epub 2002 Jul 19.

PMID:
12134060
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Iron absorption and hepatic iron uptake are increased in a transferrin receptor 2 (Y245X) mutant mouse model of hemochromatosis type 3.

Drake SF, Morgan EH, Herbison CE, Delima R, Graham RM, Chua AC, Leedman PJ, Fleming RE, Bacon BR, Olynyk JK, Trinder D.

Am J Physiol Gastrointest Liver Physiol. 2007 Jan;292(1):G323-8. Epub 2006 Aug 24.

PMID:
16935854
[PubMed - indexed for MEDLINE]
Free Article
14.

Hepatocyte-targeted HFE and TFR2 control hepcidin expression in mice.

Gao J, Chen J, De Domenico I, Koeller DM, Harding CO, Fleming RE, Koeberl DD, Enns CA.

Blood. 2010 Apr 22;115(16):3374-81. doi: 10.1182/blood-2009-09-245209. Epub 2010 Feb 22.

PMID:
20177050
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Hepatic iron deposition does not predict extrahepatic iron loading in mouse models of hereditary hemochromatosis.

Subramaniam VN, McDonald CJ, Ostini L, Lusby PE, Wockner LF, Ramm GA, Wallace DF.

Am J Pathol. 2012 Oct;181(4):1173-9. doi: 10.1016/j.ajpath.2012.06.025. Epub 2012 Jul 31.

PMID:
22858058
[PubMed - indexed for MEDLINE]
16.

Bone morphogenetic protein signaling is impaired in an HFE knockout mouse model of hemochromatosis.

Corradini E, Garuti C, Montosi G, Ventura P, Andriopoulos B Jr, Lin HY, Pietrangelo A, Babitt JL.

Gastroenterology. 2009 Oct;137(4):1489-97. doi: 10.1053/j.gastro.2009.06.057. Epub 2009 Jul 7.

PMID:
19591830
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Hepatic iron metabolism gene expression profiles in HFE associated hereditary hemochromatosis.

Gleeson F, Ryan E, Barrett S, Russell J, Crowe J.

Blood Cells Mol Dis. 2007 Jan-Feb;38(1):37-44. Epub 2006 Nov 13.

PMID:
17098454
[PubMed - indexed for MEDLINE]
18.

Transferrin receptor 2: continued expression in mouse liver in the face of iron overload and in hereditary hemochromatosis.

Fleming RE, Migas MC, Holden CC, Waheed A, Britton RS, Tomatsu S, Bacon BR, Sly WS.

Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):2214-9.

PMID:
10681454
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Hemochromatosis and pregnancy: iron stores in the Hfe-/- mouse are not reduced by multiple pregnancies.

Neves JV, Olsson IA, Porto G, Rodrigues PN.

Am J Physiol Gastrointest Liver Physiol. 2010 Apr;298(4):G525-9. doi: 10.1152/ajpgi.00449.2009. Epub 2010 Jan 28.

PMID:
20110460
[PubMed - indexed for MEDLINE]
Free Article
20.

Stoichiometries of transferrin receptors 1 and 2 in human liver.

Chloupková M, Zhang AS, Enns CA.

Blood Cells Mol Dis. 2010 Jan 15;44(1):28-33. doi: 10.1016/j.bcmd.2009.09.004. Epub 2009 Oct 12.

PMID:
19819738
[PubMed - indexed for MEDLINE]
Free PMC Article

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