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Results: 1 to 20 of 123

1.

Evaluation of disease and viral biomarkers as triggers for therapeutic intervention in respiratory mousepox - an animal model of smallpox.

Parker S, Chen NG, Foster S, Hartzler H, Hembrador E, Hruby D, Jordan R, Lanier R, Painter G, Painter W, Sagartz JE, Schriewer J, Mark Buller R.

Antiviral Res. 2012 Apr;94(1):44-53. doi: 10.1016/j.antiviral.2012.02.005. Epub 2012 Feb 18.

PMID:
22381921
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Using biomarkers to stage disease progression in a lethal mousepox model treated with CMX001.

Parker S, Schriewer J, Oberle C, Robertson A, Lanier R, Painter G, Buller RM.

Antivir Ther. 2008;13(7):863-73.

PMID:
19043920
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Efficacy of therapeutic intervention with an oral ether-lipid analogue of cidofovir (CMX001) in a lethal mousepox model.

Parker S, Touchette E, Oberle C, Almond M, Robertson A, Trost LC, Lampert B, Painter G, Buller RM.

Antiviral Res. 2008 Jan;77(1):39-49. Epub 2007 Sep 4.

PMID:
17904231
[PubMed - indexed for MEDLINE]
4.

Mousepox in the C57BL/6 strain provides an improved model for evaluating anti-poxvirus therapies.

Parker S, Siddiqui AM, Oberle C, Hembrador E, Lanier R, Painter G, Robertson A, Buller RM.

Virology. 2009 Mar 1;385(1):11-21. doi: 10.1016/j.virol.2008.11.015. Epub 2008 Dec 18.

PMID:
19100593
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

A single cidofovir treatment rescues animals at progressive stages of lethal orthopoxvirus disease.

Israely T, Paran N, Lustig S, Erez N, Politi B, Shafferman A, Melamed S.

Virol J. 2012 Jun 18;9:119. doi: 10.1186/1743-422X-9-119.

PMID:
22709563
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

A mouse model of lethal infection for evaluating prophylactics and therapeutics against Monkeypox virus.

Stabenow J, Buller RM, Schriewer J, West C, Sagartz JE, Parker S.

J Virol. 2010 Apr;84(8):3909-20. doi: 10.1128/JVI.02012-09. Epub 2010 Feb 3.

PMID:
20130052
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Efficacy of CMX001 as a post exposure antiviral in New Zealand White rabbits infected with rabbitpox virus, a model for orthopoxvirus infections of humans.

Rice AD, Adams MM, Wallace G, Burrage AM, Lindsey SF, Smith AJ, Swetnam D, Manning BR, Gray SA, Lampert B, Foster S, Lanier R, Robertson A, Painter G, Moyer RW.

Viruses. 2011 Jan;3(1):47-62. doi: 10.3390/v3010047. Review.

PMID:
21373379
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

The efficacy of cidofovir treatment of mice infected with ectromelia (mousepox) virus encoding interleukin-4.

Robbins SJ, Jackson RJ, Fenner F, Beaton S, Medveczky J, Ramshaw IA, Ramsay AJ.

Antiviral Res. 2005 Apr;66(1):1-7. Epub 2005 Jan 25.

PMID:
15781125
[PubMed - indexed for MEDLINE]
9.

Efficacy of oral active ether lipid analogs of cidofovir in a lethal mousepox model.

Buller RM, Owens G, Schriewer J, Melman L, Beadle JR, Hostetler KY.

Virology. 2004 Jan 20;318(2):474-81.

PMID:
14972516
[PubMed - indexed for MEDLINE]
10.

Synergistic efficacy of the combination of ST-246 with CMX001 against orthopoxviruses.

Quenelle DC, Prichard MN, Keith KA, Hruby DE, Jordan R, Painter GR, Robertson A, Kern ER.

Antimicrob Agents Chemother. 2007 Nov;51(11):4118-24. Epub 2007 Aug 27.

PMID:
17724153
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Efficacy of CMX001 as a prophylactic and presymptomatic antiviral agent in New Zealand white rabbits infected with rabbitpox virus, a model for orthopoxvirus infections of humans.

Rice AD, Adams MM, Lampert B, Foster S, Robertson A, Painter G, Moyer RW.

Viruses. 2011 Feb;3(2):63-82. doi: 10.3390/v3020063. Review.

PMID:
21369346
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

An orally bioavailable antipoxvirus compound (ST-246) inhibits extracellular virus formation and protects mice from lethal orthopoxvirus Challenge.

Yang G, Pevear DC, Davies MH, Collett MS, Bailey T, Rippen S, Barone L, Burns C, Rhodes G, Tohan S, Huggins JW, Baker RO, Buller RL, Touchette E, Waller K, Schriewer J, Neyts J, DeClercq E, Jones K, Hruby D, Jordan R.

J Virol. 2005 Oct;79(20):13139-49.

PMID:
16189015
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Effective antiviral treatment of systemic orthopoxvirus disease: ST-246 treatment of prairie dogs infected with monkeypox virus.

Smith SK, Self J, Weiss S, Carroll D, Braden Z, Regnery RL, Davidson W, Jordan R, Hruby DE, Damon IK.

J Virol. 2011 Sep;85(17):9176-87. doi: 10.1128/JVI.02173-10. Epub 2011 Jun 22.

PMID:
21697474
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Ectromelia virus: the causative agent of mousepox.

Esteban DJ, Buller RM.

J Gen Virol. 2005 Oct;86(Pt 10):2645-59. Review.

PMID:
16186218
[PubMed - indexed for MEDLINE]
Free Article
15.

In vivo imaging of cidofovir treatment of cowpox virus infection.

Goff A, Twenhafel N, Garrison A, Mucker E, Lawler J, Paragas J.

Virus Res. 2007 Sep;128(1-2):88-98. Epub 2007 May 23.

PMID:
17524511
[PubMed - indexed for MEDLINE]
16.

Oral 1-O-octadecyl-2-O-benzyl-sn-glycero-3-cidofovir targets the lung and is effective against a lethal respiratory challenge with ectromelia virus in mice.

Hostetler KY, Beadle JR, Trahan J, Aldern KA, Owens G, Schriewer J, Melman L, Buller RM.

Antiviral Res. 2007 Mar;73(3):212-8. Epub 2006 Nov 9.

PMID:
17123638
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

ST-246 antiviral efficacy in a nonhuman primate monkeypox model: determination of the minimal effective dose and human dose justification.

Jordan R, Goff A, Frimm A, Corrado ML, Hensley LE, Byrd CM, Mucker E, Shamblin J, Bolken TC, Wlazlowski C, Johnson W, Chapman J, Twenhafel N, Tyavanagimatt S, Amantana A, Chinsangaram J, Hruby DE, Huggins J.

Antimicrob Agents Chemother. 2009 May;53(5):1817-22. doi: 10.1128/AAC.01596-08. Epub 2009 Feb 17.

PMID:
19223621
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Pharmacokinetic and pharmacodynamic modeling to determine the dose of ST-246 to protect against smallpox in humans.

Leeds JM, Fenneteau F, Gosselin NH, Mouksassi MS, Kassir N, Marier JF, Chen Y, Grosenbach D, Frimm AE, Honeychurch KM, Chinsangaram J, Tyavanagimatt SR, Hruby DE, Jordan R.

Antimicrob Agents Chemother. 2013 Mar;57(3):1136-43. doi: 10.1128/AAC.00959-12. Epub 2012 Dec 17.

PMID:
23254433
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Tecovirimat, a p37 envelope protein inhibitor for the treatment of smallpox infection.

Duraffour S, Andrei G, Snoeck R.

IDrugs. 2010 Mar;13(3):181-91. Review.

PMID:
20191435
[PubMed - indexed for MEDLINE]
20.

Efficacy of tecovirimat (ST-246) in nonhuman primates infected with variola virus (Smallpox).

Mucker EM, Goff AJ, Shamblin JD, Grosenbach DW, Damon IK, Mehal JM, Holman RC, Carroll D, Gallardo N, Olson VA, Clemmons CJ, Hudson P, Hruby DE.

Antimicrob Agents Chemother. 2013 Dec;57(12):6246-53. doi: 10.1128/AAC.00977-13. Epub 2013 Oct 7.

PMID:
24100494
[PubMed - indexed for MEDLINE]
Free PMC Article

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