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Results: 1 to 20 of 93

1.

Inhibition of the NFAT pathway alleviates amyloid β neurotoxicity in a mouse model of Alzheimer's disease.

Hudry E, Wu HY, Arbel-Ornath M, Hashimoto T, Matsouaka R, Fan Z, Spires-Jones TL, Betensky RA, Bacskai BJ, Hyman BT.

J Neurosci. 2012 Feb 29;32(9):3176-92. doi: 10.1523/JNEUROSCI.6439-11.2012.

PMID:
22378890
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Amyloid beta induces the morphological neurodegenerative triad of spine loss, dendritic simplification, and neuritic dystrophies through calcineurin activation.

Wu HY, Hudry E, Hashimoto T, Kuchibhotla K, Rozkalne A, Fan Z, Spires-Jones T, Xie H, Arbel-Ornath M, Grosskreutz CL, Bacskai BJ, Hyman BT.

J Neurosci. 2010 Feb 17;30(7):2636-49. doi: 10.1523/JNEUROSCI.4456-09.2010.

PMID:
20164348
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Cognitive decline in Alzheimer's disease is associated with selective changes in calcineurin/NFAT signaling.

Abdul HM, Sama MA, Furman JL, Mathis DM, Beckett TL, Weidner AM, Patel ES, Baig I, Murphy MP, LeVine H 3rd, Kraner SD, Norris CM.

J Neurosci. 2009 Oct 14;29(41):12957-69. doi: 10.1523/JNEUROSCI.1064-09.2009.

PMID:
19828810
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Targeting astrocytes ameliorates neurologic changes in a mouse model of Alzheimer's disease.

Furman JL, Sama DM, Gant JC, Beckett TL, Murphy MP, Bachstetter AD, Van Eldik LJ, Norris CM.

J Neurosci. 2012 Nov 14;32(46):16129-40. doi: 10.1523/JNEUROSCI.2323-12.2012.

PMID:
23152597
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Activation of glycogen synthase kinase-3 beta mediates β-amyloid induced neuritic damage in Alzheimer's disease.

DaRocha-Souto B, Coma M, Pérez-Nievas BG, Scotton TC, Siao M, Sánchez-Ferrer P, Hashimoto T, Fan Z, Hudry E, Barroeta I, Serenó L, Rodríguez M, Sánchez MB, Hyman BT, Gómez-Isla T.

Neurobiol Dis. 2012 Jan;45(1):425-37. doi: 10.1016/j.nbd.2011.09.002. Epub 2011 Sep 13.

PMID:
21945540
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Disrupted intracellular calcium regulates BACE1 gene expression via nuclear factor of activated T cells 1 (NFAT 1) signaling.

Cho HJ, Jin SM, Youn HD, Huh K, Mook-Jung I.

Aging Cell. 2008 Mar;7(2):137-47. Epub 2007 Dec 5.

PMID:
18081741
[PubMed - indexed for MEDLINE]
7.

Distinct dendritic spine and nuclear phases of calcineurin activation after exposure to amyloid-β revealed by a novel fluorescence resonance energy transfer assay.

Wu HY, Hudry E, Hashimoto T, Uemura K, Fan ZY, Berezovska O, Grosskreutz CL, Bacskai BJ, Hyman BT.

J Neurosci. 2012 Apr 11;32(15):5298-309. doi: 10.1523/JNEUROSCI.0227-12.2012.

PMID:
22496575
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Aβ-induced Ca(2+) influx regulates astrocytic BACE1 expression via calcineurin/NFAT4 signals.

Jin SM, Cho HJ, Kim YW, Hwang JY, Mook-Jung I.

Biochem Biophys Res Commun. 2012 Aug 31;425(3):649-55. doi: 10.1016/j.bbrc.2012.07.123. Epub 2012 Jul 27.

PMID:
22846573
[PubMed - indexed for MEDLINE]
9.

RAGE regulates BACE1 and Abeta generation via NFAT1 activation in Alzheimer's disease animal model.

Cho HJ, Son SM, Jin SM, Hong HS, Shin DH, Kim SJ, Huh K, Mook-Jung I.

FASEB J. 2009 Aug;23(8):2639-49. doi: 10.1096/fj.08-126383. Epub 2009 Mar 30.

PMID:
19332646
[PubMed - indexed for MEDLINE]
Free Article
10.

Therapeutic potential of VIVIT, a selective peptide inhibitor of nuclear factor of activated T cells, in cardiovascular disorders.

Yu H, van Berkel TJ, Biessen EA.

Cardiovasc Drug Rev. 2007 Summer;25(2):175-87. Review.

PMID:
17614939
[PubMed - indexed for MEDLINE]
11.

Therapeutic potential of a synthetic peptide inhibitor of nuclear factor of activated T cells as antirestenotic agent.

Yu H, Sliedregt-Bol K, Overkleeft H, van der Marel GA, van Berkel TJ, Biessen EA.

Arterioscler Thromb Vasc Biol. 2006 Jul;26(7):1531-7. Epub 2006 May 4.

PMID:
16675727
[PubMed - indexed for MEDLINE]
Free Article
12.

Intracellular amyloid-β accumulation in calcium-binding protein-deficient neurons leads to amyloid-β plaque formation in animal model of Alzheimer's disease.

Moon M, Hong HS, Nam DW, Baik SH, Song H, Kook SY, Kim YS, Lee J, Mook-Jung I.

J Alzheimers Dis. 2012;29(3):615-28. doi: 10.3233/JAD-2011-111778.

PMID:
22269161
[PubMed - indexed for MEDLINE]
13.

Reduction of beta-amyloid pathology by celastrol in a transgenic mouse model of Alzheimer's disease.

Paris D, Ganey NJ, Laporte V, Patel NS, Beaulieu-Abdelahad D, Bachmeier C, March A, Ait-Ghezala G, Mullan MJ.

J Neuroinflammation. 2010 Mar 8;7:17. doi: 10.1186/1742-2094-7-17.

PMID:
20211007
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Specific glucose-induced control of insulin receptor substrate-2 expression is mediated via Ca2+-dependent calcineurin/NFAT signaling in primary pancreatic islet β-cells.

Demozay D, Tsunekawa S, Briaud I, Shah R, Rhodes CJ.

Diabetes. 2011 Nov;60(11):2892-902. doi: 10.2337/db11-0341. Epub 2011 Sep 22.

PMID:
21940781
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Chronic intranasal treatment with an anti-Aβ(30-42) scFv antibody ameliorates amyloid pathology in a transgenic mouse model of Alzheimer's disease.

Cattepoel S, Hanenberg M, Kulic L, Nitsch RM.

PLoS One. 2011 Apr 5;6(4):e18296. doi: 10.1371/journal.pone.0018296.

PMID:
21483675
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Tyk2/STAT3 signaling mediates beta-amyloid-induced neuronal cell death: implications in Alzheimer's disease.

Wan J, Fu AK, Ip FC, Ng HK, Hugon J, Page G, Wang JH, Lai KO, Wu Z, Ip NY.

J Neurosci. 2010 May 19;30(20):6873-81. doi: 10.1523/JNEUROSCI.0519-10.2010.

PMID:
20484629
[PubMed - indexed for MEDLINE]
Free Article
17.

Aβ₁₋₄₂-RAGE interaction disrupts tight junctions of the blood-brain barrier via Ca²⁺-calcineurin signaling.

Kook SY, Hong HS, Moon M, Ha CM, Chang S, Mook-Jung I.

J Neurosci. 2012 Jun 27;32(26):8845-54. doi: 10.1523/JNEUROSCI.6102-11.2012.

PMID:
22745485
[PubMed - indexed for MEDLINE]
Free Article
18.

Proteasome functional insufficiency activates the calcineurin-NFAT pathway in cardiomyocytes and promotes maladaptive remodelling of stressed mouse hearts.

Tang M, Li J, Huang W, Su H, Liang Q, Tian Z, Horak KM, Molkentin JD, Wang X.

Cardiovasc Res. 2010 Dec 1;88(3):424-33. doi: 10.1093/cvr/cvq217. Epub 2010 Jul 2.

PMID:
20601385
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

[Alzheimer disease: cellular and molecular aspects].

Octave JN.

Bull Mem Acad R Med Belg. 2005;160(10-12):445-9; discussion 450-1. French.

PMID:
16768248
[PubMed - indexed for MEDLINE]
20.

Neural activity regulates synaptic properties and dendritic structure in vivo through calcineurin/NFAT signaling.

Schwartz N, Schohl A, Ruthazer ES.

Neuron. 2009 Jun 11;62(5):655-69. doi: 10.1016/j.neuron.2009.05.007.

PMID:
19524525
[PubMed - indexed for MEDLINE]
Free Article

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