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Results: 1 to 20 of 107

1.

A novel "molecular tweezer" inhibitor of α-synuclein neurotoxicity in vitro and in vivo.

Prabhudesai S, Sinha S, Attar A, Kotagiri A, Fitzmaurice AG, Lakshmanan R, Ivanova MI, Loo JA, Klärner FG, Schrader T, Stahl M, Bitan G, Bronstein JM.

Neurotherapeutics. 2012 Apr;9(2):464-76. doi: 10.1007/s13311-012-0105-1. Erratum in: Neurotherapeutics. 2012 Apr;9(2):486. Lakshmanan, Ravi [corrected to Lakshmanan, Rajeswari].

PMID:
22373667
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Baicalein reduces E46K alpha-synuclein aggregation in vitro and protects cells against E46K alpha-synuclein toxicity in cell models of familiar Parkinsonism.

Jiang M, Porat-Shliom Y, Pei Z, Cheng Y, Xiang L, Sommers K, Li Q, Gillardon F, Hengerer B, Berlinicke C, Smith WW, Zack DJ, Poirier MA, Ross CA, Duan W.

J Neurochem. 2010 Jul;114(2):419-29. doi: 10.1111/j.1471-4159.2010.06752.x. Epub 2010 Apr 19.

PMID:
20412383
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Mimicking phosphorylation at serine 87 inhibits the aggregation of human α-synuclein and protects against its toxicity in a rat model of Parkinson's disease.

Oueslati A, Paleologou KE, Schneider BL, Aebischer P, Lashuel HA.

J Neurosci. 2012 Feb 1;32(5):1536-44. doi: 10.1523/JNEUROSCI.3784-11.2012.

PMID:
22302797
[PubMed - indexed for MEDLINE]
Free Article
4.

Inhibition of FK506 binding proteins reduces alpha-synuclein aggregation and Parkinson's disease-like pathology.

Gerard M, Deleersnijder A, Daniëls V, Schreurs S, Munck S, Reumers V, Pottel H, Engelborghs Y, Van den Haute C, Taymans JM, Debyser Z, Baekelandt V.

J Neurosci. 2010 Feb 17;30(7):2454-63. doi: 10.1523/JNEUROSCI.5983-09.2010.

PMID:
20164329
[PubMed - indexed for MEDLINE]
Free Article
5.

Induction of intracellular tau aggregation is promoted by α-synuclein seeds and provides novel insights into the hyperphosphorylation of tau.

Waxman EA, Giasson BI.

J Neurosci. 2011 May 25;31(21):7604-18. doi: 10.1523/JNEUROSCI.0297-11.2011.

PMID:
21613474
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Neurotoxic conversion of beta-synuclein: a novel approach to generate a transgenic mouse model of synucleinopathies?

Fujita M, Sekigawa A, Sekiyama K, Sugama S, Hashimoto M.

J Neurol. 2009 Aug;256 Suppl 3:286-92. doi: 10.1007/s00415-009-5246-8. Review.

PMID:
19711118
[PubMed - indexed for MEDLINE]
7.

Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity.

Qiao L, Hamamichi S, Caldwell KA, Caldwell GA, Yacoubian TA, Wilson S, Xie ZL, Speake LD, Parks R, Crabtree D, Liang Q, Crimmins S, Schneider L, Uchiyama Y, Iwatsubo T, Zhou Y, Peng L, Lu Y, Standaert DG, Walls KC, Shacka JJ, Roth KA, Zhang J.

Mol Brain. 2008 Nov 21;1:17. doi: 10.1186/1756-6606-1-17.

PMID:
19021916
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

α-Synuclein accumulates in huntingtin inclusions but forms independent filaments and its deficiency attenuates early phenotype in a mouse model of Huntington's disease.

Tomás-Zapico C, Díez-Zaera M, Ferrer I, Gómez-Ramos P, Morán MA, Miras-Portugal MT, Díaz-Hernández M, Lucas JJ.

Hum Mol Genet. 2012 Feb 1;21(3):495-510. doi: 10.1093/hmg/ddr507. Epub 2011 Nov 1.

PMID:
22045698
[PubMed - indexed for MEDLINE]
Free Article
9.

A strategy for designing inhibitors of alpha-synuclein aggregation and toxicity as a novel treatment for Parkinson's disease and related disorders.

El-Agnaf OM, Paleologou KE, Greer B, Abogrein AM, King JE, Salem SA, Fullwood NJ, Benson FE, Hewitt R, Ford KJ, Martin FL, Harriott P, Cookson MR, Allsop D.

FASEB J. 2004 Aug;18(11):1315-7. Epub 2004 Jun 4.

PMID:
15180968
[PubMed - indexed for MEDLINE]
Free Article
10.

Macroautophagy and the proteasome are differently involved in the degradation of alpha-synuclein wild type and mutated A30P in an in vitro inducible model (PC12/TetOn).

Batelli S, Peverelli E, Rodilossi S, Forloni G, Albani D.

Neuroscience. 2011 Nov 10;195:128-37. doi: 10.1016/j.neuroscience.2011.08.030. Epub 2011 Aug 19.

PMID:
21906659
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

alpha-Synuclein expression levels do not significantly affect proteasome function and expression in mice and stably transfected PC12 cell lines.

Martìn-Clemente B, Alvarez-Castelao B, Mayo I, Sierra AB, Dìaz V, Milán M, Fariñas I, Gómez-Isla T, Ferrer I, Castaño JG.

J Biol Chem. 2004 Dec 17;279(51):52984-90. Epub 2004 Oct 4.

PMID:
15466467
[PubMed - indexed for MEDLINE]
Free Article
12.

Baicalein inhibits formation of α-synuclein oligomers within living cells and prevents Aβ peptide fibrillation and oligomerisation.

Lu JH, Ardah MT, Durairajan SS, Liu LF, Xie LX, Fong WF, Hasan MY, Huang JD, El-Agnaf OM, Li M.

Chembiochem. 2011 Mar 7;12(4):615-24. doi: 10.1002/cbic.201000604. Epub 2011 Jan 26.

PMID:
21271629
[PubMed - indexed for MEDLINE]
13.

Physiology and pathophysiology of alpha-synuclein. Cell culture and transgenic animal models based on a Parkinson's disease-associated protein.

Kahle PJ, Neumann M, Ozmen L, Haass C.

Ann N Y Acad Sci. 2000;920:33-41. Review.

PMID:
11193173
[PubMed - indexed for MEDLINE]
14.

Selective loss of dopaminergic neurons and formation of Lewy body-like aggregations in alpha-synuclein transgenic fly neuronal cultures.

Park SS, Lee D.

Eur J Neurosci. 2006 Jun;23(11):2908-14.

PMID:
16819979
[PubMed - indexed for MEDLINE]
15.

Convergence of heat shock protein 90 with ubiquitin in filamentous alpha-synuclein inclusions of alpha-synucleinopathies.

Uryu K, Richter-Landsberg C, Welch W, Sun E, Goldbaum O, Norris EH, Pham CT, Yazawa I, Hilburger K, Micsenyi M, Giasson BI, Bonini NM, Lee VM, Trojanowski JQ.

Am J Pathol. 2006 Mar;168(3):947-61.

PMID:
16507910
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Oxidative stress-induced phosphorylation, degradation and aggregation of alpha-synuclein are linked to upregulated CK2 and cathepsin D.

Takahashi M, Ko LW, Kulathingal J, Jiang P, Sevlever D, Yen SH.

Eur J Neurosci. 2007 Aug;26(4):863-74.

PMID:
17714183
[PubMed - indexed for MEDLINE]
17.

A novel, high-efficiency cellular model of fibrillar alpha-synuclein inclusions and the examination of mutations that inhibit amyloid formation.

Waxman EA, Giasson BI.

J Neurochem. 2010 Apr;113(2):374-88. doi: 10.1111/j.1471-4159.2010.06592.x. Epub 2010 Feb 2.

PMID:
20132485
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Neuropathology of synuclein aggregates.

Duda JE, Lee VM, Trojanowski JQ.

J Neurosci Res. 2000 Jul 15;61(2):121-7. Review.

PMID:
10878583
[PubMed - indexed for MEDLINE]
19.

Reciprocal effects of alpha-synuclein overexpression and proteasome inhibition in neuronal cells and tissue.

Dyllick-Brenzinger M, D'Souza CA, Dahlmann B, Kloetzel PM, Tandon A.

Neurotox Res. 2010 Apr;17(3):215-27. doi: 10.1007/s12640-009-9094-1. Epub 2009 Aug 4.

PMID:
19653055
[PubMed - indexed for MEDLINE]
20.

Inhibition of α-synuclein aggregation by small heat shock proteins.

Bruinsma IB, Bruggink KA, Kinast K, Versleijen AA, Segers-Nolten IM, Subramaniam V, Kuiperij HB, Boelens W, de Waal RM, Verbeek MM.

Proteins. 2011 Oct;79(10):2956-67. doi: 10.1002/prot.23152. Epub 2011 Aug 26.

PMID:
21905118
[PubMed - indexed for MEDLINE]
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