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Items: 1 to 20 of 143

1.

Effect of the PTPN22 and INS risk genotypes on the progression to clinical type 1 diabetes after the initiation of β-cell autoimmunity.

Lempainen J, Hermann R, Veijola R, Simell O, Knip M, Ilonen J.

Diabetes. 2012 Apr;61(4):963-6. doi: 10.2337/db11-0386. Epub 2012 Feb 22.

2.

Do non-HLA genes influence development of persistent islet autoimmunity and type 1 diabetes in children with high-risk HLA-DR,DQ genotypes?

Steck AK, Zhang W, Bugawan TL, Barriga KJ, Blair A, Erlich HA, Eisenbarth GS, Norris JM, Rewers MJ.

Diabetes. 2009 Apr;58(4):1028-33. doi: 10.2337/db08-1179. Epub 2009 Feb 2.

3.

Lymphoid tyrosine phosphatase (LYP/PTPN22) Arg620Trp variant regulates insulin autoimmunity and progression to type 1 diabetes.

Hermann R, Lipponen K, Kiviniemi M, Kakko T, Veijola R, Simell O, Knip M, Ilonen J.

Diabetologia. 2006 Jun;49(6):1198-208. Epub 2006 Apr 14.

PMID:
16614815
4.

Interplay between PTPN22 C1858T polymorphism and cow's milk formula exposure in type 1 diabetes.

Lempainen J, Vaarala O, Mäkelä M, Veijola R, Simell O, Knip M, Hermann R, Ilonen J.

J Autoimmun. 2009 Sep;33(2):155-64. doi: 10.1016/j.jaut.2009.04.003. Epub 2009 May 26.

PMID:
19473815
5.

Non-HLA gene effects on the disease process of type 1 diabetes: From HLA susceptibility to overt disease.

Lempainen J, Laine AP, Hammais A, Toppari J, Simell O, Veijola R, Knip M, Ilonen J.

J Autoimmun. 2015 Jul;61:45-53. doi: 10.1016/j.jaut.2015.05.005. Epub 2015 Jun 12.

PMID:
26074154
6.

Effect of HLA class I and class II alleles on progression from autoantibody positivity to overt type 1 diabetes in children with risk-associated class II genotypes.

Lipponen K, Gombos Z, Kiviniemi M, Siljander H, Lempainen J, Hermann R, Veijola R, Simell O, Knip M, Ilonen J.

Diabetes. 2010 Dec;59(12):3253-6. doi: 10.2337/db10-0167. Epub 2010 Aug 25.

7.

The association between the PTPN22 1858C>T variant and type 1 diabetes depends on HLA risk and GAD65 autoantibodies.

Maziarz M, Janer M, Roach JC, Hagopian W, Palmer JP, Deutsch K, Sanjeevi CB, Kockum I, Breslow N, Lernmark A; Swedish Childhood Diabetes Register; Diabetes Incidence in Sweden Study Group.

Genes Immun. 2010 Jul;11(5):406-15. doi: 10.1038/gene.2010.12. Epub 2010 May 6.

8.

Impact of diabetes susceptibility loci on progression from pre-diabetes to diabetes in at-risk individuals of the diabetes prevention trial-type 1 (DPT-1).

Butty V, Campbell C, Mathis D, Benoist C; DPT-1 Study Group.

Diabetes. 2008 Sep;57(9):2348-59. doi: 10.2337/db07-1736. Epub 2008 Jun 12.

9.

IDDM2/insulin VNTR modifies risk conferred by IDDM1/HLA for development of Type 1 diabetes and associated autoimmunity.

Walter M, Albert E, Conrad M, Keller E, Hummel M, Ferber K, Barratt BJ, Todd JA, Ziegler AG, Bonifacio E.

Diabetologia. 2003 May;46(5):712-20. Epub 2003 May 16.

PMID:
12750767
10.

Joint effects of HLA, INS, PTPN22 and CTLA4 genes on the risk of type 1 diabetes.

Bjørnvold M, Undlien DE, Joner G, Dahl-Jørgensen K, Njølstad PR, Akselsen HE, Gervin K, Rønningen KS, Stene LC.

Diabetologia. 2008 Apr;51(4):589-96. doi: 10.1007/s00125-008-0932-0. Epub 2008 Feb 22.

11.

Assessment of type 1 diabetes risk conferred by HLA-DRB1, INS-VNTR and PTPN22 genes using the Bayesian network approach.

Portuesi R, Pozzilli P, Boehm B, Buzzetti R, Filippi S.

PLoS One. 2013 Nov 18;8(11):e79506. doi: 10.1371/journal.pone.0079506. eCollection 2013.

12.

LADA and T1D in Estonian population - two different genetic risk profiles.

Kisand K, Uibo R.

Gene. 2012 Apr 15;497(2):285-91. doi: 10.1016/j.gene.2012.01.089. Epub 2012 Feb 3.

PMID:
22326526
13.

Genetic risk markers related to diabetes-associated autoantibodies in young patients with type 1 diabetes in berlin, Germany.

Kordonouri O, Hartmann R, Charpentier N, Knip M, Danne T, Ilonen J.

Exp Clin Endocrinol Diabetes. 2010 Apr;118(4):245-9. doi: 10.1055/s-0029-1246213. Epub 2010 Feb 5.

PMID:
20140847
14.

Improving prediction of type 1 diabetes by testing non-HLA genetic variants in addition to HLA markers.

Steck AK, Dong F, Wong R, Fouts A, Liu E, Romanos J, Wijmenga C, Norris JM, Rewers MJ.

Pediatr Diabetes. 2014 Aug;15(5):355-62. Epub 2013 Nov 8.

15.

Insulin secretion and sensitivity in the prediction of type 1 diabetes in children with advanced β-cell autoimmunity.

Siljander HT, Hermann R, Hekkala A, Lähde J, Tanner L, Keskinen P, Ilonen J, Simell O, Veijola R, Knip M.

Eur J Endocrinol. 2013 Sep 14;169(4):479-85. doi: 10.1530/EJE-13-0206. Print 2013 Oct.

16.

Autoimmunity in primary antibody deficiency is associated with protein tyrosine phosphatase nonreceptor type 22 (PTPN22).

Chew GY, Sinha U, Gatenby PA, DeMalmanche T, Adelstein S, Garsia R, Hissaria P, French MA, Wilson A, Whittle B, Kirkpatrick P, Riminton DS, Fulcher DA, Cook MC.

J Allergy Clin Immunol. 2013 Apr;131(4):1130-5, 1135.e1. doi: 10.1016/j.jaci.2012.06.023. Epub 2012 Jul 31.

PMID:
22857794
17.

Associations of polymorphisms in non-HLA loci with autoantibodies at the diagnosis of type 1 diabetes: INS and IKZF4 associate with insulin autoantibodies.

Lempainen J, Härkönen T, Laine A, Knip M, Ilonen J; Finnish Pediatric Diabetes Register.

Pediatr Diabetes. 2013 Nov;14(7):490-6. doi: 10.1111/pedi.12046. Epub 2013 May 31.

PMID:
23721563
18.

Patterns of β-cell autoantibody appearance and genetic associations during the first years of life.

Ilonen J, Hammais A, Laine AP, Lempainen J, Vaarala O, Veijola R, Simell O, Knip M.

Diabetes. 2013 Oct;62(10):3636-40. doi: 10.2337/db13-0300. Epub 2013 Jul 8.

19.

Investigation of the vitamin D receptor gene (VDR) and its interaction with protein tyrosine phosphatase, non-receptor type 2 gene (PTPN2) on risk of islet autoimmunity and type 1 diabetes: the Diabetes Autoimmunity Study in the Young (DAISY).

Frederiksen B, Liu E, Romanos J, Steck AK, Yin X, Kroehl M, Fingerlin TE, Erlich H, Eisenbarth GS, Rewers M, Norris JM.

J Steroid Biochem Mol Biol. 2013 Jan;133:51-7. doi: 10.1016/j.jsbmb.2012.08.012. Epub 2012 Sep 7.

20.

Association of variants in HLA-DQA1-DQB1, PTPN22, INS, and CTLA4 with GAD autoantibodies and insulin secretion in nondiabetic adults of the Botnia Prospective Study.

Andersen MK, Lundgren V, Isomaa B, Groop L, Tuomi T.

Eur J Endocrinol. 2012 Jul;167(1):27-33. doi: 10.1530/EJE-12-0023. Epub 2012 Apr 16.

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