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Results: 1 to 20 of 107

1.

SAR and biological evaluation of 3-azabicyclo[3.1.0]hexane derivatives as μ opioid ligands.

Lunn G, Roberts LR, Content S, Critcher DJ, Douglas S, Fenwick AE, Gethin DM, Goodwin G, Greenway D, Greenwood S, Hall K, Thomas M, Thompson S, Williams D, Wood G, Wylie A.

Bioorg Med Chem Lett. 2012 Mar 15;22(6):2200-3. doi: 10.1016/j.bmcl.2012.01.099. Epub 2012 Feb 2.

PMID:
22357342
[PubMed - indexed for MEDLINE]
2.

Synthesis, opioid receptor binding, and bioassay of naltrindole analogues substituted in the indolic benzene moiety.

Ananthan S, Johnson CA, Carter RL, Clayton SD, Rice KC, Xu H, Davis P, Porreca F, Rothman RB.

J Med Chem. 1998 Jul 16;41(15):2872-81.

PMID:
9667975
[PubMed - indexed for MEDLINE]
3.

Biaryl piperidines as potent and selective delta opioid receptor ligands.

Liras S, McHardy SF, Allen MP, Segelstein BE, Heck SD, Bryce DK, Schmidt AW, Vanase-Frawley M, Callegari E, McLean S.

Bioorg Med Chem Lett. 2010 Jan 15;20(2):503-7. doi: 10.1016/j.bmcl.2009.11.113. Epub 2009 Nov 26.

PMID:
20015649
[PubMed - indexed for MEDLINE]
4.

Discovery and synthesis of a new class of opioid ligand having a 3-azabicyclo[3.1.0]hexane core. An example of a 'magic methyl' giving a 35-fold improvement in binding.

Lunn G, Banks BJ, Crook R, Feeder N, Pettman A, Sabnis Y.

Bioorg Med Chem Lett. 2011 Aug 1;21(15):4608-11. doi: 10.1016/j.bmcl.2011.05.132. Epub 2011 Jun 16.

PMID:
21737265
[PubMed - indexed for MEDLINE]
5.

Novel ligands for the opioid receptors: synthesis and structure-activity relationships among 5'-aryl and 5'-heteroaryl 17-cyclopropylmethyl-4,5 alpha-epoxypyrido[2',3':6,7]morphinans.

Ananthan S, Khare NK, Saini SK, Davis P, Dersch CM, Porreca F, Rothman RB.

Bioorg Med Chem. 2003 Sep 1;11(18):4143-54.

PMID:
12927876
[PubMed - indexed for MEDLINE]
6.

Synthesis of 3,6-diazabicyclo[3.1.1]heptanes as novel ligands for the opioid receptors.

Loriga G, Manca I, Murineddu G, Chelucci G, Villa S, Gessi S, Toma L, Cignarella G, Pinna GA.

Bioorg Med Chem. 2006 Feb 1;14(3):676-91. Epub 2005 Oct 20.

PMID:
16243530
[PubMed - indexed for MEDLINE]
7.

Effect of N-alkyl and N-alkenyl substituents in noroxymorphindole, 17-substituted-6,7-dehydro-4,5alpha-epoxy-3,14-dihydroxy-6,7:2',3'-indolomorphinans, on opioid receptor affinity, selectivity, and efficacy.

McLamore S, Ullrich T, Rothman RB, Xu H, Dersch C, Coop A, Davis P, Porreca F, Jacobson AE, Rice KC.

J Med Chem. 2001 Apr 26;44(9):1471-4.

PMID:
11311071
[PubMed - indexed for MEDLINE]
8.

Factors influencing agonist potency and selectivity for the opioid delta receptor are revealed in structure-activity relationship studies of the 4-[(N-substituted-4-piperidinyl)arylamino]-N,N-diethylbenzamides.

Thomas JB, Herault XM, Rothman RB, Atkinson RN, Burgess JP, Mascarella SW, Dersch CM, Xu H, Flippen-Anderson JL, George CF, Carroll FI.

J Med Chem. 2001 Mar 15;44(6):972-87.

PMID:
11300879
[PubMed - indexed for MEDLINE]
9.

Synthesis and opioid receptor affinity of a series of 2, 4-diaryl-substituted 3,7-diazabicylononanones.

Siener T, Cambareri A, Kuhl U, Englberger W, Haurand M, Kögel B, Holzgrabe U.

J Med Chem. 2000 Oct 5;43(20):3746-51.

PMID:
11020289
[PubMed - indexed for MEDLINE]
10.

Probes for narcotic receptor mediated phenomena. 34. Synthesis and structure-activity relationships of a potent mu-agonist delta-antagonist and an exceedingly potent antinociceptive in the enantiomeric C9-substituted 5-(3-hydroxyphenyl)-N-phenylethylmorphan series.

Hiebel AC, Lee YS, Bilsky E, Giuvelis D, Deschamps JR, Parrish DA, Aceto MD, May EL, Harris LS, Coop A, Dersch CM, Partilla JS, Rothman RB, Cheng K, Jacobson AE, Rice KC.

J Med Chem. 2007 Aug 9;50(16):3765-76. Epub 2007 Jul 11.

PMID:
17625813
[PubMed - indexed for MEDLINE]
11.

Kappa-receptor selective binding of opioid ligands with a heterocyclic bicyclo[3.3.1]nonan-9-one structure.

Benyhe S, Márki A, Nachtsheim C, Holzgrabe U, Borsodi A.

Acta Biol Hung. 2003;54(2):147-55.

PMID:
14535620
[PubMed - indexed for MEDLINE]
Free Article
12.

Opioid binding profiles of new hydrazone, oxime, carbazone and semicarbazone derivatives of 14-alkoxymorphinans.

Monory K, Greiner E, Sartania N, Sallai L, Pouille Y, Schmidhammer H, Hanoune J, Borsodi A.

Life Sci. 1999;64(22):2011-20.

PMID:
10374926
[PubMed - indexed for MEDLINE]
13.

The region in the mu opioid receptor conferring selectivity for sufentanil over the delta receptor is different from that over the kappa receptor.

Zhu J, Xue JC, Law PY, Claude PA, Luo LY, Yin J, Chen C, Liu-Chen LY.

FEBS Lett. 1996 Apr 15;384(2):198-202.

PMID:
8612823
[PubMed - indexed for MEDLINE]
Free Article
14.

Investigation of the selectivity of oxymorphone- and naltrexone-derived ligands via site-directed mutagenesis of opioid receptors: exploring the "address" recognition locus.

Metzger TG, Paterlini MG, Ferguson DM, Portoghese PS.

J Med Chem. 2001 Mar 15;44(6):857-62.

PMID:
11300867
[PubMed - indexed for MEDLINE]
15.

Identification of the first trans-(3R,4R)- dimethyl-4-(3-hydroxyphenyl)piperidine derivative to possess highly potent and selective opioid kappa receptor antagonist activity.

Thomas JB, Atkinson RN, Rothman RB, Fix SE, Mascarella SW, Vinson NA, Xu H, Dersch CM, Lu Y, Cantrell BE, Zimmerman DM, Carroll FI.

J Med Chem. 2001 Aug 16;44(17):2687-90.

PMID:
11495579
[PubMed - indexed for MEDLINE]
16.

Highly potent and selective phenylmorphan-based inverse agonists of the opioid delta receptor.

Thomas JB, Zhang L, Navarro HA, Carroll FI.

J Med Chem. 2006 Sep 7;49(18):5597-609.

PMID:
16942033
[PubMed - indexed for MEDLINE]
17.

Synthesis and preliminary in vitro investigation of bivalent ligands containing homo- and heterodimeric pharmacophores at mu, delta, and kappa opioid receptors.

Peng X, Knapp BI, Bidlack JM, Neumeyer JL.

J Med Chem. 2006 Jan 12;49(1):256-62.

PMID:
16392810
[PubMed - indexed for MEDLINE]
18.

Synthesis and pharmacological evaluation of novel octahydro-1H-pyrido[1,2-a]pyrazine as mu-opioid receptor antagonists.

Le Bourdonnec B, Goodman AJ, Graczyk TM, Belanger S, Seida PR, DeHaven RN, Dolle RE.

J Med Chem. 2006 Dec 14;49(25):7290-306.

PMID:
17149859
[PubMed - indexed for MEDLINE]
19.

Involvement of peripheral mu opioid receptors in scratching behavior in mice.

Yamamoto A, Sugimoto Y.

Eur J Pharmacol. 2010 Dec 15;649(1-3):336-41. doi: 10.1016/j.ejphar.2010.07.039. Epub 2010 Sep 20.

PMID:
20863827
[PubMed - indexed for MEDLINE]
20.

The bovine pineal gland contains delta and mu but not kappa or ORL1 opioid receptor subtypes.

Govitrapong P, Sawlom S, Chetsawang B, Sangchot P, Ebadi M.

Proc West Pharmacol Soc. 2002;45:32-5. No abstract available.

PMID:
12434519
[PubMed - indexed for MEDLINE]

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