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Results: 1 to 20 of 126

1.

Requirements for efficient proteolytic cleavage of prelamin A by ZMPSTE24.

Barrowman J, Hamblet C, Kane MS, Michaelis S.

PLoS One. 2012;7(2):e32120. doi: 10.1371/journal.pone.0032120. Epub 2012 Feb 15.

PMID:
22355414
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Inhibiting farnesylation reverses the nuclear morphology defect in a HeLa cell model for Hutchinson-Gilford progeria syndrome.

Mallampalli MP, Huyer G, Bendale P, Gelb MH, Michaelis S.

Proc Natl Acad Sci U S A. 2005 Oct 4;102(40):14416-21. Epub 2005 Sep 26.

PMID:
16186497
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

ZMPSTE24, an integral membrane zinc metalloprotease with a connection to progeroid disorders.

Barrowman J, Michaelis S.

Biol Chem. 2009 Aug;390(8):761-73. doi: 10.1515/BC.2009.080. Review.

PMID:
19453269
[PubMed - indexed for MEDLINE]
4.

Analysis of prelamin A biogenesis reveals the nucleus to be a CaaX processing compartment.

Barrowman J, Hamblet C, George CM, Michaelis S.

Mol Biol Cell. 2008 Dec;19(12):5398-408. doi: 10.1091/mbc.E08-07-0704. Epub 2008 Oct 15.

PMID:
18923140
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Different prelamin A forms accumulate in human fibroblasts: a study in experimental models and progeria.

Dominici S, Fiori V, Magnani M, Schena E, Capanni C, Camozzi D, D'Apice MR, Le Dour C, Auclair M, Caron M, Novelli G, Vigouroux C, Maraldi NM, Lattanzi G.

Eur J Histochem. 2009 Jan-Mar;53(1):43-52.

PMID:
19351612
[PubMed - indexed for MEDLINE]
6.

Prelamin A, Zmpste24, misshapen cell nuclei, and progeria--new evidence suggesting that protein farnesylation could be important for disease pathogenesis.

Young SG, Fong LG, Michaelis S.

J Lipid Res. 2005 Dec;46(12):2531-58. Epub 2005 Oct 5. Review.

PMID:
16207929
[PubMed - indexed for MEDLINE]
Free Article
7.

Prelamin A endoproteolytic processing in vitro by recombinant Zmpste24.

Corrigan DP, Kuszczak D, Rusinol AE, Thewke DP, Hrycyna CA, Michaelis S, Sinensky MS.

Biochem J. 2005 Apr 1;387(Pt 1):129-38.

PMID:
15479156
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Human ZMPSTE24 disease mutations: residual proteolytic activity correlates with disease severity.

Barrowman J, Wiley PA, Hudon-Miller SE, Hrycyna CA, Michaelis S.

Hum Mol Genet. 2012 Sep 15;21(18):4084-93. doi: 10.1093/hmg/dds233. Epub 2012 Jun 19.

PMID:
22718200
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Heterozygosity for Lmna deficiency eliminates the progeria-like phenotypes in Zmpste24-deficient mice.

Fong LG, Ng JK, Meta M, Coté N, Yang SH, Stewart CL, Sullivan T, Burghardt A, Majumdar S, Reue K, Bergo MO, Young SG.

Proc Natl Acad Sci U S A. 2004 Dec 28;101(52):18111-6. Epub 2004 Dec 17.

PMID:
15608054
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Blocking protein farnesyltransferase improves nuclear shape in fibroblasts from humans with progeroid syndromes.

Toth JI, Yang SH, Qiao X, Beigneux AP, Gelb MH, Moulson CL, Miner JH, Young SG, Fong LG.

Proc Natl Acad Sci U S A. 2005 Sep 6;102(36):12873-8. Epub 2005 Aug 29.

PMID:
16129834
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Prenylated prelamin A interacts with Narf, a novel nuclear protein.

Barton RM, Worman HJ.

J Biol Chem. 1999 Oct 15;274(42):30008-18.

PMID:
10514485
[PubMed - indexed for MEDLINE]
Free Article
12.

Prelamin A farnesylation and progeroid syndromes.

Young SG, Meta M, Yang SH, Fong LG.

J Biol Chem. 2006 Dec 29;281(52):39741-5. Epub 2006 Nov 7. Review.

PMID:
17090536
[PubMed - indexed for MEDLINE]
Free Article
13.

Identification of mitochondrial dysfunction in Hutchinson-Gilford progeria syndrome through use of stable isotope labeling with amino acids in cell culture.

Rivera-Torres J, Acín-Perez R, Cabezas-Sánchez P, Osorio FG, Gonzalez-Gómez C, Megias D, Cámara C, López-Otín C, Enríquez JA, Luque-García JL, Andrés V.

J Proteomics. 2013 Oct 8;91:466-77. doi: 10.1016/j.jprot.2013.08.008. Epub 2013 Aug 20.

PMID:
23969228
[PubMed - in process]
14.

Type B mandibuloacral dysplasia with congenital myopathy due to homozygous ZMPSTE24 missense mutation.

Ben Yaou R, Navarro C, Quijano-Roy S, Bertrand AT, Massart C, De Sandre-Giovannoli A, Cadiñanos J, Mamchaoui K, Butler-Browne G, Estournet B, Richard P, Barois A, Lévy N, Bonne G.

Eur J Hum Genet. 2011 Jun;19(6):647-54. doi: 10.1038/ejhg.2010.256. Epub 2011 Jan 26.

PMID:
21267004
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Zmpste24 deficiency in mice causes spontaneous bone fractures, muscle weakness, and a prelamin A processing defect.

Bergo MO, Gavino B, Ross J, Schmidt WK, Hong C, Kendall LV, Mohr A, Meta M, Genant H, Jiang Y, Wisner ER, Van Bruggen N, Carano RA, Michaelis S, Griffey SM, Young SG.

Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):13049-54. Epub 2002 Sep 16.

PMID:
12235369
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Accumulation of distinct prelamin A variants in human diploid fibroblasts differentially affects cell homeostasis.

Candelario J, Borrego S, Reddy S, Comai L.

Exp Cell Res. 2011 Feb 1;317(3):319-29. doi: 10.1016/j.yexcr.2010.10.014. Epub 2010 Oct 23.

PMID:
20974128
[PubMed - indexed for MEDLINE]
17.

Nucleoplasmic localization of prelamin A: implications for prenylation-dependent lamin A assembly into the nuclear lamina.

Lutz RJ, Trujillo MA, Denham KS, Wenger L, Sinensky M.

Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):3000-4. Erratum in: Proc Natl Acad Sci U S A 1992 Jun 15;89(12):5699.

PMID:
1557405
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

N6-isopentenyladenosine improves nuclear shape in fibroblasts from humans with progeroid syndromes by inhibiting the farnesylation of prelamin A.

Bifulco M, D'Alessandro A, Paladino S, Malfitano AM, Notarnicola M, Caruso MG, Laezza C.

FEBS J. 2013 Dec;280(23):6223-32. doi: 10.1111/febs.12544. Epub 2013 Nov 18.

PMID:
24112551
[PubMed - indexed for MEDLINE]
19.

Inhibitors of protein geranylgeranyltransferase-I lead to prelamin A accumulation in cells by inhibiting ZMPSTE24.

Chang SY, Hudon-Miller SE, Yang SH, Jung HJ, Lee JM, Farber E, Subramanian T, Andres DA, Spielmann HP, Hrycyna CA, Young SG, Fong LG.

J Lipid Res. 2012 Jun;53(6):1176-82. doi: 10.1194/jlr.M026161. Epub 2012 Mar 23.

PMID:
22448028
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

The processing pathway of prelamin A.

Sinensky M, Fantle K, Trujillo M, McLain T, Kupfer A, Dalton M.

J Cell Sci. 1994 Jan;107 ( Pt 1):61-7.

PMID:
8175923
[PubMed - indexed for MEDLINE]
Free Article

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