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Association of plasma n-6 and n-3 polyunsaturated fatty acids with synovitis in the knee: the MOST study.

Baker KR, Matthan NR, Lichtenstein AH, Niu J, Guermazi A, Roemer F, Grainger A, Nevitt MC, Clancy M, Lewis CE, Torner JC, Felson DT.

Osteoarthritis Cartilage. 2012 May;20(5):382-7. doi: 10.1016/j.joca.2012.01.021. Epub 2012 Feb 4.


Synovitis in knee osteoarthritis assessed by contrast-enhanced magnetic resonance imaging (MRI) is associated with radiographic tibiofemoral osteoarthritis and MRI-detected widespread cartilage damage: the MOST study.

Guermazi A, Hayashi D, Roemer FW, Zhu Y, Niu J, Crema MD, Javaid MK, Marra MD, Lynch JA, El-Khoury GY, Zhang Y, Nevitt MC, Felson DT.

J Rheumatol. 2014 Mar;41(3):501-8. doi: 10.3899/jrheum.130541. Epub 2014 Jan 15.


Metabolic enrichment of omega-3 polyunsaturated fatty acids does not reduce the onset of idiopathic knee osteoarthritis in mice.

Cai A, Hutchison E, Hudson J, Kawashima Y, Komori N, Singh A, Brush RS, Anderson RE, Sonntag WE, Matsumoto H, Griffin TM.

Osteoarthritis Cartilage. 2014 Sep;22(9):1301-9. doi: 10.1016/j.joca.2014.06.033. Epub 2014 Jul 4.


Relation of synovitis to knee pain using contrast-enhanced MRIs.

Baker K, Grainger A, Niu J, Clancy M, Guermazi A, Crema M, Hughes L, Buckwalter J, Wooley A, Nevitt M, Felson DT.

Ann Rheum Dis. 2010 Oct;69(10):1779-83. doi: 10.1136/ard.2009.121426. Epub 2010 May 14.


Synovitis detected on magnetic resonance imaging and its relation to pain and cartilage loss in knee osteoarthritis.

Hill CL, Hunter DJ, Niu J, Clancy M, Guermazi A, Genant H, Gale D, Grainger A, Conaghan P, Felson DT.

Ann Rheum Dis. 2007 Dec;66(12):1599-603. Epub 2007 May 9.


Presence of MRI-detected joint effusion and synovitis increases the risk of cartilage loss in knees without osteoarthritis at 30-month follow-up: the MOST study.

Roemer FW, Guermazi A, Felson DT, Niu J, Nevitt MC, Crema MD, Lynch JA, Lewis CE, Torner J, Zhang Y.

Ann Rheum Dis. 2011 Oct;70(10):1804-9. doi: 10.1136/ard.2011.150243. Epub 2011 Jul 25.


Assessment of synovitis with contrast-enhanced MRI using a whole-joint semiquantitative scoring system in people with, or at high risk of, knee osteoarthritis: the MOST study.

Guermazi A, Roemer FW, Hayashi D, Crema MD, Niu J, Zhang Y, Marra MD, Katur A, Lynch JA, El-Khoury GY, Baker K, Hughes LB, Nevitt MC, Felson DT.

Ann Rheum Dis. 2011 May;70(5):805-11. doi: 10.1136/ard.2010.139618. Epub 2010 Dec 27.


Effect of fatty acids on bone marrow lesions and knee cartilage in healthy, middle-aged subjects without clinical knee osteoarthritis.

Wang Y, Wluka AE, Hodge AM, English DR, Giles GG, O'Sullivan R, Cicuttini FM.

Osteoarthritis Cartilage. 2008 May;16(5):579-83. Epub 2007 Oct 15.


A new non-invasive method to assess synovitis severity in relation to symptoms and cartilage volume loss in knee osteoarthritis patients using MRI.

Pelletier JP, Raynauld JP, Abram F, Haraoui B, Choquette D, Martel-Pelletier J.

Osteoarthritis Cartilage. 2008;16 Suppl 3:S8-13. doi: 10.1016/j.joca.2008.06.007. Epub 2008 Jul 30.


Quantitative magnetic resonance imaging evidence of synovial proliferation is associated with radiographic severity of knee osteoarthritis.

Krasnokutsky S, Belitskaya-Lévy I, Bencardino J, Samuels J, Attur M, Regatte R, Rosenthal P, Greenberg J, Schweitzer M, Abramson SB, Rybak L.

Arthritis Rheum. 2011 Oct;63(10):2983-91. doi: 10.1002/art.30471.


Knee osteoarthritis. Efficacy of a new method of contrast-enhanced musculoskeletal ultrasonography in detection of synovitis in patients with knee osteoarthritis in comparison with magnetic resonance imaging.

Song IH, Althoff CE, Hermann KG, Scheel AK, Knetsch T, Schoenharting M, Werner C, Burmester GR, Backhaus M.

Ann Rheum Dis. 2008 Jan;67(1):19-25. Erratum in: Ann Rheum Dis. 2009 Jan;68(1):156.


Tibiofemoral joint osteoarthritis: risk factors for MR-depicted fast cartilage loss over a 30-month period in the multicenter osteoarthritis study.

Roemer FW, Zhang Y, Niu J, Lynch JA, Crema MD, Marra MD, Nevitt MC, Felson DT, Hughes LB, El-Khoury GY, Englund M, Guermazi A; Multicenter Osteoarthritis Study Investigators.

Radiology. 2009 Sep;252(3):772-80. doi: 10.1148/radiol.2523082197. Epub 2009 Jul 27.


Cartilage markers and their association with cartilage loss on magnetic resonance imaging in knee osteoarthritis: the Boston Osteoarthritis Knee Study.

Hunter DJ, Li J, LaValley M, Bauer DC, Nevitt M, DeGroot J, Poole R, Eyre D, Guermazi A, Gale D, Felson DT.

Arthritis Res Ther. 2007;9(5):R108.


Dietary fatty acid content regulates wound repair and the pathogenesis of osteoarthritis following joint injury.

Wu CL, Jain D, McNeill JN, Little D, Anderson JA, Huebner JL, Kraus VB, Rodriguiz RM, Wetsel WC, Guilak F.

Ann Rheum Dis. 2015 Nov;74(11):2076-83. doi: 10.1136/annrheumdis-2014-205601. Epub 2014 Jul 10.


Macroscopic and microscopic features of synovial membrane inflammation in the osteoarthritic knee: correlating magnetic resonance imaging findings with disease severity.

Loeuille D, Chary-Valckenaere I, Champigneulle J, Rat AC, Toussaint F, Pinzano-Watrin A, Goebel JC, Mainard D, Blum A, Pourel J, Netter P, Gillet P.

Arthritis Rheum. 2005 Nov;52(11):3492-501.


The association between meniscal damage of the posterior horns and localized posterior synovitis detected on T1-weighted contrast-enhanced MRI--the MOST study.

Roemer FW, Felson DT, Yang T, Niu J, Crema MD, Englund M, Nevitt MC, Zhang Y, Lynch JA, El Khoury GY, Torner J, Lewis CE, Guermazi A.

Semin Arthritis Rheum. 2013 Jun;42(6):573-81. doi: 10.1016/j.semarthrit.2012.10.005. Epub 2012 Dec 25.


The relationship between specific tissue lesions and pain severity in persons with knee osteoarthritis.

Torres L, Dunlop DD, Peterfy C, Guermazi A, Prasad P, Hayes KW, Song J, Cahue S, Chang A, Marshall M, Sharma L.

Osteoarthritis Cartilage. 2006 Oct;14(10):1033-40. Epub 2006 May 18.


Anatomical distribution of synovitis in knee osteoarthritis and its association with joint effusion assessed on non-enhanced and contrast-enhanced MRI.

Roemer FW, Kassim Javaid M, Guermazi A, Thomas M, Kiran A, Keen R, King L, Arden NK.

Osteoarthritis Cartilage. 2010 Oct;18(10):1269-74. doi: 10.1016/j.joca.2010.07.008. Epub 2010 Aug 5.


Acetaminophen, like conventional NSAIDs, may reduce synovitis in osteoarthritic knees.

Brandt KD, Mazzuca SA, Buckwalter KA.

Rheumatology (Oxford). 2006 Nov;45(11):1389-94. Epub 2006 Apr 10.

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