Format
Sort by

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 103

1.

A cell-based assay for screening spindle checkpoint inhibitors.

Wu ZH, Hu LY, Xu da Q, Li X.

Assay Drug Dev Technol. 2012 Aug;10(4):344-52. doi: 10.1089/adt.2011.416. Epub 2012 Feb 21.

2.

A high throughput, whole cell screen for small molecule inhibitors of the mitotic spindle checkpoint identifies OM137, a novel Aurora kinase inhibitor.

DeMoe JH, Santaguida S, Daum JR, Musacchio A, Gorbsky GJ.

Cancer Res. 2009 Feb 15;69(4):1509-16. doi: 10.1158/0008-5472.CAN-08-3133. Epub 2009 Feb 3.

3.

Pharmacologic abrogation of the mitotic spindle checkpoint by an indolocarbazole discovered by cellular screening efficiently kills cancer cells.

Stolz A, Vogel C, Schneider V, Ertych N, Kienitz A, Yu H, Bastians H.

Cancer Res. 2009 May 1;69(9):3874-83. doi: 10.1158/0008-5472.CAN-08-3597. Epub 2009 Apr 14.

4.

Mitotic spindle checkpoint inactivation by trichostatin a defines a mechanism for increasing cancer cell killing by microtubule-disrupting agents.

Dowling M, Voong KR, Kim M, Keutmann MK, Harris E, Kao GD.

Cancer Biol Ther. 2005 Feb;4(2):197-206. Epub 2005 Feb 8.

PMID:
15753652
5.

Growth suppression and mitotic defect induced by JNJ-7706621, an inhibitor of cyclin-dependent kinases and aurora kinases.

Matsuhashi A, Ohno T, Kimura M, Hara A, Saio M, Nagano A, Kawai G, Saitou M, Takigami I, Yamada K, Okano Y, Shimizu K.

Curr Cancer Drug Targets. 2012 Jul;12(6):625-39.

PMID:
22463590
6.

The flavonoid eupatorin inactivates the mitotic checkpoint leading to polyploidy and apoptosis.

Salmela AL, Pouwels J, Kukkonen-Macchi A, Waris S, Toivonen P, Jaakkola K, Mäki-Jouppila J, Kallio L, Kallio MJ.

Exp Cell Res. 2012 Mar 10;318(5):578-92. doi: 10.1016/j.yexcr.2011.12.014. Epub 2011 Dec 29.

PMID:
22227008
7.

The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint.

Hauf S, Cole RW, LaTerra S, Zimmer C, Schnapp G, Walter R, Heckel A, van Meel J, Rieder CL, Peters JM.

J Cell Biol. 2003 Apr 28;161(2):281-94. Epub 2003 Apr 21.

8.

The mitotic spindle checkpoint is a critical determinant for topoisomerase-based chemotherapy.

Vogel C, Kienitz A, Müller R, Bastians H.

J Biol Chem. 2005 Feb 11;280(6):4025-8. Epub 2004 Dec 16.

9.

Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine.

Santaguida S, Tighe A, D'Alise AM, Taylor SS, Musacchio A.

J Cell Biol. 2010 Jul 12;190(1):73-87. doi: 10.1083/jcb.201001036.

11.

Disruption of astral microtubule contact with the cell cortex activates a Bub1, Bub3, and Mad3-dependent checkpoint in fission yeast.

Tournier S, Gachet Y, Buck V, Hyams JS, Millar JB.

Mol Biol Cell. 2004 Jul;15(7):3345-56. Epub 2004 May 14.

12.

Raf kinase inhibitory protein regulates aurora B kinase and the spindle checkpoint.

Eves EM, Shapiro P, Naik K, Klein UR, Trakul N, Rosner MR.

Mol Cell. 2006 Aug;23(4):561-74.

13.

p55CDC/hCDC20 mutant induces mitotic catastrophe by inhibiting the MAD2-dependent spindle checkpoint activity in tumor cells.

Sihn CR, Suh EJ, Lee KH, Kim TY, Kim SH.

Cancer Lett. 2003 Nov 25;201(2):203-10.

PMID:
14607335
14.

The investigational Aurora kinase A inhibitor MLN8237 induces defects in cell viability and cell-cycle progression in malignant bladder cancer cells in vitro and in vivo.

Zhou N, Singh K, Mir MC, Parker Y, Lindner D, Dreicer R, Ecsedy JA, Zhang Z, Teh BT, Almasan A, Hansel DE.

Clin Cancer Res. 2013 Apr 1;19(7):1717-28. doi: 10.1158/1078-0432.CCR-12-2383. Epub 2013 Feb 12.

15.

The natural product Aristolactam AIIIa as a new ligand targeting the polo-box domain of polo-like kinase 1 potently inhibits cancer cell proliferation.

Li L, Wang X, Chen J, Ding H, Zhang Y, Hu TC, Hu LH, Jiang HL, Shen X.

Acta Pharmacol Sin. 2009 Oct;30(10):1443-53. doi: 10.1038/aps.2009.141.

16.

Evidence that Aurora B is implicated in spindle checkpoint signalling independently of error correction.

Santaguida S, Vernieri C, Villa F, Ciliberto A, Musacchio A.

EMBO J. 2011 Apr 20;30(8):1508-19. doi: 10.1038/emboj.2011.70. Epub 2011 Mar 15.

17.

NEK2A interacts with MAD1 and possibly functions as a novel integrator of the spindle checkpoint signaling.

Lou Y, Yao J, Zereshki A, Dou Z, Ahmed K, Wang H, Hu J, Wang Y, Yao X.

J Biol Chem. 2004 May 7;279(19):20049-57. Epub 2004 Feb 20.

18.

p53 activation in response to mitotic spindle damage requires signaling via BubR1-mediated phosphorylation.

Ha GH, Baek KH, Kim HS, Jeong SJ, Kim CM, McKeon F, Lee CW.

Cancer Res. 2007 Aug 1;67(15):7155-64.

19.

Protein kinases involved in mitotic spindle checkpoint regulation.

Hoffmann I.

Results Probl Cell Differ. 2006;42:93-109. Review.

PMID:
16903209
20.

Polo-like kinase 1 inhibitor BI2536 causes mitotic catastrophe following activation of the spindle assembly checkpoint in non-small cell lung cancer cells.

Choi M, Kim W, Cheon MG, Lee CW, Kim JE.

Cancer Lett. 2015 Feb 28;357(2):591-601. doi: 10.1016/j.canlet.2014.12.023. Epub 2014 Dec 15.

PMID:
25524551
Items per page

Supplemental Content

Write to the Help Desk