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Lethal myelofibrosis induced by Bmi1-deficient hematopoietic cells unveils a tumor suppressor function of the polycomb group genes.

Oguro H, Yuan J, Tanaka S, Miyagi S, Mochizuki-Kashio M, Ichikawa H, Yamazaki S, Koseki H, Nakauchi H, Iwama A.

J Exp Med. 2012 Mar 12;209(3):445-54. doi: 10.1084/jem.20111709. Epub 2012 Feb 20.


A novel zinc finger protein Zfp277 mediates transcriptional repression of the Ink4a/arf locus through polycomb repressive complex 1.

Negishi M, Saraya A, Mochizuki S, Helin K, Koseki H, Iwama A.

PLoS One. 2010 Aug 24;5(8):e12373. doi: 10.1371/journal.pone.0012373.


Ink4a and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice.

Bruggeman SW, Valk-Lingbeek ME, van der Stoop PP, Jacobs JJ, Kieboom K, Tanger E, Hulsman D, Leung C, Arsenijevic Y, Marino S, van Lohuizen M.

Genes Dev. 2005 Jun 15;19(12):1438-43.


Differential impact of Ink4a and Arf on hematopoietic stem cells and their bone marrow microenvironment in Bmi1-deficient mice.

Oguro H, Iwama A, Morita Y, Kamijo T, van Lohuizen M, Nakauchi H.

J Exp Med. 2006 Oct 2;203(10):2247-53. Epub 2006 Sep 5.


Functional antagonism of the Polycomb-Group genes eed and Bmi1 in hemopoietic cell proliferation.

Lessard J, Schumacher A, Thorsteinsdottir U, van Lohuizen M, Magnuson T, Sauvageau G.

Genes Dev. 1999 Oct 15;13(20):2691-703.


Bmi1 promotes hepatic stem cell expansion and tumorigenicity in both Ink4a/Arf-dependent and -independent manners in mice.

Chiba T, Seki A, Aoki R, Ichikawa H, Negishi M, Miyagi S, Oguro H, Saraya A, Kamiya A, Nakauchi H, Yokosuka O, Iwama A.

Hepatology. 2010 Sep;52(3):1111-23. doi: 10.1002/hep.23793.


Transcriptional coactivator Cited2 induces Bmi1 and Mel18 and controls fibroblast proliferation via Ink4a/ARF.

Kranc KR, Bamforth SD, Bragan├ža J, Norbury C, van Lohuizen M, Bhattacharya S.

Mol Cell Biol. 2003 Nov;23(21):7658-66.


Polycomb mediated epigenetic silencing and replication timing at the INK4a/ARF locus during senescence.

Agherbi H, Gaussmann-Wenger A, Verthuy C, Chasson L, Serrano M, Djabali M.

PLoS One. 2009 May 20;4(5):e5622. doi: 10.1371/journal.pone.0005622.


E4F1: a novel candidate factor for mediating BMI1 function in primitive hematopoietic cells.

Chagraoui J, Niessen SL, Lessard J, Girard S, Coulombe P, Sauvageau M, Meloche S, Sauvageau G.

Genes Dev. 2006 Aug 1;20(15):2110-20.


Bmi1 confers resistance to oxidative stress on hematopoietic stem cells.

Nakamura S, Oshima M, Yuan J, Saraya A, Miyagi S, Konuma T, Yamazaki S, Osawa M, Nakauchi H, Koseki H, Iwama A.

PLoS One. 2012;7(5):e36209. doi: 10.1371/journal.pone.0036209. Epub 2012 May 11.


Bmi1 deficient neural stem cells have increased integrin dependent adhesion to self-secreted matrix.

Bruggeman SW, Hulsman D, van Lohuizen M.

Biochim Biophys Acta. 2009 May;1790(5):351-60. doi: 10.1016/j.bbagen.2009.03.009. Epub 2009 Mar 16.


Bmi1 controls tumor development in an Ink4a/Arf-independent manner in a mouse model for glioma.

Bruggeman SW, Hulsman D, Tanger E, Buckle T, Blom M, Zevenhoven J, van Tellingen O, van Lohuizen M.

Cancer Cell. 2007 Oct;12(4):328-41.


Bmi1 is required for regeneration of the exocrine pancreas in mice.

Fukuda A, Morris JP 4th, Hebrok M.

Gastroenterology. 2012 Sep;143(3):821-31.e1-2. doi: 10.1053/j.gastro.2012.05.009. Epub 2012 May 17.


Polycomb group protein Bmi1 promotes hematopoietic cell development from embryonic stem cells.

Ding X, Lin Q, Ensenat-Waser R, Rose-John S, Zenke M.

Stem Cells Dev. 2012 Jan;21(1):121-32. doi: 10.1089/scd.2010.0539. Epub 2011 Jun 17.


The polycomb group gene product Ezh2 regulates proliferation and differentiation of murine hepatic stem/progenitor cells.

Aoki R, Chiba T, Miyagi S, Negishi M, Konuma T, Taniguchi H, Ogawa M, Yokosuka O, Iwama A.

J Hepatol. 2010 Jun;52(6):854-63. doi: 10.1016/j.jhep.2010.01.027. Epub 2010 Mar 24.


Essential role for activation of the Polycomb group (PcG) protein chromatin silencing pathway in metastatic prostate cancer.

Berezovska OP, Glinskii AB, Yang Z, Li XM, Hoffman RM, Glinsky GV.

Cell Cycle. 2006 Aug;5(16):1886-901. Epub 2006 Aug 15.


Bmi1 is essential for leukemic reprogramming of myeloid progenitor cells.

Yuan J, Takeuchi M, Negishi M, Oguro H, Ichikawa H, Iwama A.

Leukemia. 2011 Aug;25(8):1335-43. doi: 10.1038/leu.2011.85. Epub 2011 Apr 29.


Tumor suppressor function of the polycomb group genes.

Mochizuki-Kashio M, Wendt GR, Iwama A.

Cell Cycle. 2012 Jun 1;11(11):2043-4. doi: 10.4161/cc.20533. Epub 2012 Jun 1. No abstract available.


Polycomb (PcG) proteins, BMI1 and SUZ12, regulate arsenic-induced cell transformation.

Kim HG, Kim DJ, Li S, Lee KY, Li X, Bode AM, Dong Z.

J Biol Chem. 2012 Sep 14;287(38):31920-8. doi: 10.1074/jbc.M112.360362. Epub 2012 Jul 28.

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