Display Settings:

Format
Items per page
Sort by

Send to:

Choose Destination

Results: 1 to 20 of 654

1.

Protein kinase CK2 protects multiple myeloma cells from ER stress-induced apoptosis and from the cytotoxic effect of HSP90 inhibition through regulation of the unfolded protein response.

Manni S, Brancalion A, Tubi LQ, Colpo A, Pavan L, Cabrelle A, Ave E, Zaffino F, Di Maira G, Ruzzene M, Adami F, Zambello R, Pitari MR, Tassone P, Pinna LA, Gurrieri C, Semenzato G, Piazza F.

Clin Cancer Res. 2012 Apr 1;18(7):1888-900. doi: 10.1158/1078-0432.CCR-11-1789. Epub 2012 Feb 20.

PMID:
22351691
[PubMed - indexed for MEDLINE]
Free Article
2.

IPI-504, a novel and soluble HSP-90 inhibitor, blocks the unfolded protein response in multiple myeloma cells.

Patterson J, Palombella VJ, Fritz C, Normant E.

Cancer Chemother Pharmacol. 2008 May;61(6):923-32. Epub 2007 Jul 12.

PMID:
17624530
[PubMed - indexed for MEDLINE]
3.

Apigenin inhibits proliferation and induces apoptosis in human multiple myeloma cells through targeting the trinity of CK2, Cdc37 and Hsp90.

Zhao M, Ma J, Zhu HY, Zhang XH, Du ZY, Xu YJ, Yu XD.

Mol Cancer. 2011 Aug 29;10:104. doi: 10.1186/1476-4598-10-104.

PMID:
21871133
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Protein kinase CK2 inhibition down modulates the NF-κB and STAT3 survival pathways, enhances the cellular proteotoxic stress and synergistically boosts the cytotoxic effect of bortezomib on multiple myeloma and mantle cell lymphoma cells.

Manni S, Brancalion A, Mandato E, Tubi LQ, Colpo A, Pizzi M, Cappellesso R, Zaffino F, Di Maggio SA, Cabrelle A, Marino F, Zambello R, Trentin L, Adami F, Gurrieri C, Semenzato G, Piazza F.

PLoS One. 2013 Sep 27;8(9):e75280. doi: 10.1371/journal.pone.0075280. eCollection 2013.

PMID:
24086494
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Heat shock protein inhibition is associated with activation of the unfolded protein response pathway in myeloma plasma cells.

Davenport EL, Moore HE, Dunlop AS, Sharp SY, Workman P, Morgan GJ, Davies FE.

Blood. 2007 Oct 1;110(7):2641-9. Epub 2007 May 24.

PMID:
17525289
[PubMed - indexed for MEDLINE]
Free Article
6.

An activated JAK/STAT3 pathway and CD45 expression are associated with sensitivity to Hsp90 inhibitors in multiple myeloma.

Lin H, Kolosenko I, Björklund AC, Protsyuk D, Österborg A, Grandér D, Tamm KP.

Exp Cell Res. 2013 Mar 10;319(5):600-11. doi: 10.1016/j.yexcr.2012.12.006. Epub 2012 Dec 13.

PMID:
23246572
[PubMed - indexed for MEDLINE]
7.

Inhibition of casein kinase 2 modulates XBP1-GRP78 arm of unfolded protein responses in cultured glial cells.

Hosoi T, Korematsu K, Horie N, Suezawa T, Okuma Y, Nomura Y, Ozawa K.

PLoS One. 2012;7(6):e40144. doi: 10.1371/journal.pone.0040144. Epub 2012 Jun 29.

PMID:
22768244
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Hsp90 inhibition by PU-H71 induces apoptosis through endoplasmic reticulum stress and mitochondrial pathway in cancer cells and overcomes the resistance conferred by Bcl-2.

Gallerne C, Prola A, Lemaire C.

Biochim Biophys Acta. 2013 Jun;1833(6):1356-66. doi: 10.1016/j.bbamcr.2013.02.014. Epub 2013 Feb 26.

PMID:
23485394
[PubMed - indexed for MEDLINE]
Free Article
9.

The Hsp90 inhibitor IPI-504 overcomes bortezomib resistance in mantle cell lymphoma in vitro and in vivo by down-regulation of the prosurvival ER chaperone BiP/Grp78.

Roué G, Pérez-Galán P, Mozos A, López-Guerra M, Xargay-Torrent S, Rosich L, Saborit-Villarroya I, Normant E, Campo E, Colomer D.

Blood. 2011 Jan 27;117(4):1270-9. doi: 10.1182/blood-2010-04-278853. Epub 2010 Nov 24.

PMID:
21106982
[PubMed - indexed for MEDLINE]
Free Article
10.

Specific regulation of noncanonical p38alpha activation by Hsp90-Cdc37 chaperone complex in cardiomyocyte.

Ota A, Zhang J, Ping P, Han J, Wang Y.

Circ Res. 2010 Apr 30;106(8):1404-12. doi: 10.1161/CIRCRESAHA.109.213769. Epub 2010 Mar 18.

PMID:
20299663
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Sulforaphane synergistically enhances the cytotoxicity of arsenic trioxide in multiple myeloma cells via stress-mediated pathways.

Doudican NA, Wen SY, Mazumder A, Orlow SJ.

Oncol Rep. 2012 Nov;28(5):1851-8. doi: 10.3892/or.2012.1977. Epub 2012 Aug 22.

PMID:
22922937
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Analysis of expression of heat shock protein-90 (HSP90) and the effects of HSP90 inhibitor (17-AAG) in multiple myeloma.

Duus J, Bahar HI, Venkataraman G, Ozpuyan F, Izban KF, Al-Masri H, Maududi T, Toor A, Alkan S.

Leuk Lymphoma. 2006 Jul;47(7):1369-78.

PMID:
16923571
[PubMed - indexed for MEDLINE]
13.

Cdc37/Hsp90 protein-mediated regulation of IRE1α protein activity in endoplasmic reticulum stress response and insulin synthesis in INS-1 cells.

Ota A, Wang Y.

J Biol Chem. 2012 Feb 24;287(9):6266-74. doi: 10.1074/jbc.M111.331264. Epub 2011 Dec 23.

PMID:
22199355
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Hsp90 inhibitors, GA and 17AAG, lead to ER stress-induced apoptosis in rat histiocytoma.

Taiyab A, Sreedhar AS, Rao ChM.

Biochem Pharmacol. 2009 Jul 15;78(2):142-52. doi: 10.1016/j.bcp.2009.04.001. Epub 2009 Apr 9.

PMID:
19464431
[PubMed - indexed for MEDLINE]
15.

Heat shock protein 90 modulates the unfolded protein response by stabilizing IRE1alpha.

Marcu MG, Doyle M, Bertolotti A, Ron D, Hendershot L, Neckers L.

Mol Cell Biol. 2002 Dec;22(24):8506-13.

PMID:
12446770
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Efficacy of Hsp90 inhibition for induction of apoptosis and inhibition of growth in cervical carcinoma cells in vitro and in vivo.

Schwock J, Pham NA, Cao MP, Hedley DW.

Cancer Chemother Pharmacol. 2008 Apr;61(4):669-81. Epub 2007 Jun 20.

PMID:
17579866
[PubMed - indexed for MEDLINE]
17.

Role of CAAT/enhancer binding protein homologous protein in panobinostat-mediated potentiation of bortezomib-induced lethal endoplasmic reticulum stress in mantle cell lymphoma cells.

Rao R, Nalluri S, Fiskus W, Savoie A, Buckley KM, Ha K, Balusu R, Joshi A, Coothankandaswamy V, Tao J, Sotomayor E, Atadja P, Bhalla KN.

Clin Cancer Res. 2010 Oct 1;16(19):4742-54. doi: 10.1158/1078-0432.CCR-10-0529. Epub 2010 Jul 20.

PMID:
20647473
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

New molecular and biological mechanism of antitumor activities of KW-2478, a novel nonansamycin heat shock protein 90 inhibitor, in multiple myeloma cells.

Nakashima T, Ishii T, Tagaya H, Seike T, Nakagawa H, Kanda Y, Akinaga S, Soga S, Shiotsu Y.

Clin Cancer Res. 2010 May 15;16(10):2792-802. doi: 10.1158/1078-0432.CCR-09-3112. Epub 2010 Apr 20.

PMID:
20406843
[PubMed - indexed for MEDLINE]
Free Article
19.
20.

The unfolded protein response: controlling cell fate decisions under ER stress and beyond.

Hetz C.

Nat Rev Mol Cell Biol. 2012 Jan 18;13(2):89-102. doi: 10.1038/nrm3270. Review.

PMID:
22251901
[PubMed - indexed for MEDLINE]

Display Settings:

Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

Write to the Help Desk