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Results: 1 to 20 of 147

1.

Butyrate activates the monocarboxylate transporter MCT4 expression in breast cancer cells and enhances the antitumor activity of 3-bromopyruvate.

Queirós O, Preto A, Pacheco A, Pinheiro C, Azevedo-Silva J, Moreira R, Pedro M, Ko YH, Pedersen PL, Baltazar F, Casal M.

J Bioenerg Biomembr. 2012 Feb;44(1):141-53. doi: 10.1007/s10863-012-9418-3. Epub 2012 Feb 17.

PMID:
22350013
[PubMed - indexed for MEDLINE]
2.

Monocarboxylate transporter 4 regulates maturation and trafficking of CD147 to the plasma membrane in the metastatic breast cancer cell line MDA-MB-231.

Gallagher SM, Castorino JJ, Wang D, Philp NJ.

Cancer Res. 2007 May 1;67(9):4182-9.

PMID:
17483329
[PubMed - indexed for MEDLINE]
Free Article
3.

CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors.

Le Floch R, Chiche J, Marchiq I, Naiken T, Ilc K, Murray CM, Critchlow SE, Roux D, Simon MP, Pouysségur J.

Proc Natl Acad Sci U S A. 2011 Oct 4;108(40):16663-8. doi: 10.1073/pnas.1106123108. Epub 2011 Sep 19. Erratum in: Proc Natl Acad Sci U S A. 2012 Dec 4;109(49):20166. Naïken, Tanesha [corrected to Naiken, Tanesha]; Ilk, Karine [corrected to Ilc, Karine].

PMID:
21930917
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

3-Bromopyruvate antagonizes effects of lactate and pyruvate, synergizes with citrate and exerts novel anti-glioma effects.

El Sayed SM, El-Magd RM, Shishido Y, Chung SP, Diem TH, Sakai T, Watanabe H, Kagami S, Fukui K.

J Bioenerg Biomembr. 2012 Feb;44(1):61-79. doi: 10.1007/s10863-012-9409-4. Epub 2012 Feb 9.

PMID:
22318356
[PubMed - indexed for MEDLINE]
5.

Evidence for a stromal-epithelial "lactate shuttle" in human tumors: MCT4 is a marker of oxidative stress in cancer-associated fibroblasts.

Whitaker-Menezes D, Martinez-Outschoorn UE, Lin Z, Ertel A, Flomenberg N, Witkiewicz AK, Birbe RC, Howell A, Pavlides S, Gandara R, Pestell RG, Sotgia F, Philp NJ, Lisanti MP.

Cell Cycle. 2011 Jun 1;10(11):1772-83. Epub 2011 Jun 1.

PMID:
21558814
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Using the "reverse Warburg effect" to identify high-risk breast cancer patients: stromal MCT4 predicts poor clinical outcome in triple-negative breast cancers.

Witkiewicz AK, Whitaker-Menezes D, Dasgupta A, Philp NJ, Lin Z, Gandara R, Sneddon S, Martinez-Outschoorn UE, Sotgia F, Lisanti MP.

Cell Cycle. 2012 Mar 15;11(6):1108-17. doi: 10.4161/cc.11.6.19530. Epub 2012 Mar 15.

PMID:
22313602
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Monocarboxylate 4 mediated butyrate transport in a rat intestinal epithelial cell line.

Kekuda R, Manoharan P, Baseler W, Sundaram U.

Dig Dis Sci. 2013 Mar;58(3):660-7. doi: 10.1007/s10620-012-2407-x. Epub 2013 Jan 24.

PMID:
23344966
[PubMed - indexed for MEDLINE]
8.

Monocarboxylate transporter 1 is up-regulated in basal-like breast carcinoma.

Pinheiro C, Albergaria A, Paredes J, Sousa B, Dufloth R, Vieira D, Schmitt F, Baltazar F.

Histopathology. 2010 Jun;56(7):860-7. doi: 10.1111/j.1365-2559.2010.03560.x.

PMID:
20636790
[PubMed - indexed for MEDLINE]
9.

CD147 silencing inhibits lactate transport and reduces malignant potential of pancreatic cancer cells in in vivo and in vitro models.

Schneiderhan W, Scheler M, Holzmann KH, Marx M, Gschwend JE, Bucholz M, Gress TM, Seufferlein T, Adler G, Oswald F.

Gut. 2009 Oct;58(10):1391-8. doi: 10.1136/gut.2009.181412. Epub 2009 Jun 7.

PMID:
19505879
[PubMed - indexed for MEDLINE]
10.

Monocarboxylate transporters (MCTs) in gliomas: expression and exploitation as therapeutic targets.

Miranda-Gonçalves V, Honavar M, Pinheiro C, Martinho O, Pires MM, Pinheiro C, Cordeiro M, Bebiano G, Costa P, Palmeirim I, Reis RM, Baltazar F.

Neuro Oncol. 2013 Feb;15(2):172-88. doi: 10.1093/neuonc/nos298. Epub 2012 Dec 20.

PMID:
23258846
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Alterations of monocarboxylate transporter densities during hypoxia in brain and breast tumour cells.

Cheng C, Edin NF, Lauritzen KH, Aspmodal I, Christoffersen S, Jian L, Rasmussen LJ, Pettersen EO, Xiaoqun G, Bergersen LH.

Cell Oncol (Dordr). 2012 Jun;35(3):217-27. doi: 10.1007/s13402-012-0081-9. Epub 2012 Jun 15.

PMID:
22700320
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Monocarboxylate transporters 1 and 4 are involved in the invasion activity of human lung cancer cells.

Izumi H, Takahashi M, Uramoto H, Nakayama Y, Oyama T, Wang KY, Sasaguri Y, Nishizawa S, Kohno K.

Cancer Sci. 2011 May;102(5):1007-13. doi: 10.1111/j.1349-7006.2011.01908.x. Epub 2011 Mar 7.

PMID:
21306479
[PubMed - indexed for MEDLINE]
13.

Hyaluronan, CD44, and emmprin regulate lactate efflux and membrane localization of monocarboxylate transporters in human breast carcinoma cells.

Slomiany MG, Grass GD, Robertson AD, Yang XY, Maria BL, Beeson C, Toole BP.

Cancer Res. 2009 Feb 15;69(4):1293-301. doi: 10.1158/0008-5472.CAN-08-2491. Epub 2009 Jan 27.

PMID:
19176383
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Mitochondrial and plasma membrane lactate transporter and lactate dehydrogenase isoform expression in breast cancer cell lines.

Hussien R, Brooks GA.

Physiol Genomics. 2011 Mar 16;43(5):255-64. doi: 10.1152/physiolgenomics.00177.2010. Epub 2010 Dec 21.

PMID:
21177384
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Expression of monocarboxylate transporters 1, 2, and 4 in human tumours and their association with CD147 and CD44.

Pinheiro C, Reis RM, Ricardo S, Longatto-Filho A, Schmitt F, Baltazar F.

J Biomed Biotechnol. 2010;2010:427694. doi: 10.1155/2010/427694. Epub 2010 May 4.

PMID:
20454640
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Cancer metabolism, stemness and tumor recurrence: MCT1 and MCT4 are functional biomarkers of metabolic symbiosis in head and neck cancer.

Curry JM, Tuluc M, Whitaker-Menezes D, Ames JA, Anantharaman A, Butera A, Leiby B, Cognetti DM, Sotgia F, Lisanti MP, Martinez-Outschoorn UE.

Cell Cycle. 2013 May 1;12(9):1371-84. doi: 10.4161/cc.24092. Epub 2013 Apr 10.

PMID:
23574725
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Differential sensitivities to lactate transport inhibitors of breast cancer cell lines.

Morais-Santos F, Miranda-Gonçalves V, Pinheiro S, Vieira AF, Paredes J, Schmitt FC, Baltazar F, Pinheiro C.

Endocr Relat Cancer. 2013 Dec 16;21(1):27-38. doi: 10.1530/ERC-13-0132. Print 2014 Feb.

PMID:
24174370
[PubMed - indexed for MEDLINE]
19.

A CD147-targeting siRNA inhibits the proliferation, invasiveness, and VEGF production of human malignant melanoma cells by down-regulating glycolysis.

Su J, Chen X, Kanekura T.

Cancer Lett. 2009 Jan 8;273(1):140-7. doi: 10.1016/j.canlet.2008.07.034. Epub 2008 Sep 7.

PMID:
18778892
[PubMed - indexed for MEDLINE]
20.

Role of monocarboxylate transporters in human cancers: state of the art.

Pinheiro C, Longatto-Filho A, Azevedo-Silva J, Casal M, Schmitt FC, Baltazar F.

J Bioenerg Biomembr. 2012 Feb;44(1):127-39. doi: 10.1007/s10863-012-9428-1. Review.

PMID:
22407107
[PubMed - indexed for MEDLINE]

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