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Results: 1 to 20 of 88

1.

Involvement of PDK1, PKC and TOR signalling pathways in basal fluconazole tolerance in Cryptococcus neoformans.

Lee H, Khanal Lamichhane A, Garraffo HM, Kwon-Chung KJ, Chang YC.

Mol Microbiol. 2012 Apr;84(1):130-46. doi: 10.1111/j.1365-2958.2012.08016.x. Epub 2012 Mar 15.

PMID:
22339665
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Cryptococcus neoformans phosphoinositide-dependent kinase 1 (PDK1) ortholog is required for stress tolerance and survival in murine phagocytes.

Chabrier-Roselló Y, Gerik KJ, Koselny K, DiDone L, Lodge JK, Krysan DJ.

Eukaryot Cell. 2013 Jan;12(1):12-22. doi: 10.1128/EC.00235-12. Epub 2012 Oct 19.

PMID:
23087368
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

A defect in iron uptake enhances the susceptibility of Cryptococcus neoformans to azole antifungal drugs.

Kim J, Cho YJ, Do E, Choi J, Hu G, Cadieux B, Chun J, Lee Y, Kronstad JW, Jung WH.

Fungal Genet Biol. 2012 Nov;49(11):955-66. doi: 10.1016/j.fgb.2012.08.006. Epub 2012 Sep 4.

PMID:
22975303
[PubMed - indexed for MEDLINE]
4.

A putative P-type ATPase, Apt1, is involved in stress tolerance and virulence in Cryptococcus neoformans.

Hu G, Kronstad JW.

Eukaryot Cell. 2010 Jan;9(1):74-83. doi: 10.1128/EC.00289-09. Epub 2009 Nov 30.

PMID:
19949048
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Heteroresistance to fluconazole in Cryptococcus neoformans is intrinsic and associated with virulence.

Sionov E, Chang YC, Garraffo HM, Kwon-Chung KJ.

Antimicrob Agents Chemother. 2009 Jul;53(7):2804-15. doi: 10.1128/AAC.00295-09. Epub 2009 May 4.

PMID:
19414582
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Role of AFR1, an ABC transporter-encoding gene, in the in vivo response to fluconazole and virulence of Cryptococcus neoformans.

Sanguinetti M, Posteraro B, La Sorda M, Torelli R, Fiori B, Santangelo R, Delogu G, Fadda G.

Infect Immun. 2006 Feb;74(2):1352-9.

PMID:
16428784
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

The Cryptococcus neoformans MAP kinase Mpk1 regulates cell integrity in response to antifungal drugs and loss of calcineurin function.

Kraus PR, Fox DS, Cox GM, Heitman J.

Mol Microbiol. 2003 Jun;48(5):1377-87.

PMID:
12787363
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

A flucytosine-responsive Mbp1/Swi4-like protein, Mbs1, plays pleiotropic roles in antifungal drug resistance, stress response, and virulence of Cryptococcus neoformans.

Song MH, Lee JW, Kim MS, Yoon JK, White TC, Floyd A, Heitman J, Strain AK, Nielsen JN, Nielsen K, Bahn YS.

Eukaryot Cell. 2012 Jan;11(1):53-67. doi: 10.1128/EC.05236-11. Epub 2011 Nov 11.

PMID:
22080454
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

The casein kinase I protein Cck1 regulates multiple signaling pathways and is essential for cell integrity and fungal virulence in Cryptococcus neoformans.

Wang Y, Liu TB, Patel S, Jiang L, Xue C.

Eukaryot Cell. 2011 Nov;10(11):1455-64. doi: 10.1128/EC.05207-11. Epub 2011 Sep 16.

PMID:
21926330
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Conservation of the sterol regulatory element-binding protein pathway and its pathobiological importance in Cryptococcus neoformans.

Chang YC, Ingavale SS, Bien C, Espenshade P, Kwon-Chung KJ.

Eukaryot Cell. 2009 Nov;8(11):1770-9. doi: 10.1128/EC.00207-09. Epub 2009 Sep 11.

PMID:
19749173
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Azole heteroresistance in Cryptococcus neoformans: emergence of resistant clones with chromosomal disomy in the mouse brain during fluconazole treatment.

Sionov E, Chang YC, Kwon-Chung KJ.

Antimicrob Agents Chemother. 2013 Oct;57(10):5127-30. doi: 10.1128/AAC.00694-13. Epub 2013 Jul 8.

PMID:
23836187
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Identification and characterization of a Cryptococcus neoformans ATP binding cassette (ABC) transporter-encoding gene, CnAFR1, involved in the resistance to fluconazole.

Posteraro B, Sanguinetti M, Sanglard D, La Sorda M, Boccia S, Romano L, Morace G, Fadda G.

Mol Microbiol. 2003 Jan;47(2):357-71.

PMID:
12519188
[PubMed - indexed for MEDLINE]
13.

Overexpression of TUF1 restores respiratory growth and fluconazole sensitivity to a Cryptococcus neoformans vad1Delta mutant.

Panepinto JC, Misener AL, Oliver BG, Hu G, Park YD, Shin S, White TC, Williamson PR.

Microbiology. 2010 Aug;156(Pt 8):2558-65. doi: 10.1099/mic.0.035923-0. Epub 2010 Apr 29.

PMID:
20430817
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Cryptococcus neoformans Yop1 , an endoplasmic reticulum curvature-stabilizing protein, participates with Sey1 in influencing fluconazole-induced disomy formation.

Ngamskulrungroj P, Chang Y, Hansen B, Bugge C, Fischer E, Kwon-Chung KJ.

FEMS Yeast Res. 2012 Nov;12(7):748-54. doi: 10.1111/j.1567-1364.2012.00824.x. Epub 2012 Jul 18.

PMID:
22731401
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Role and mechanism of phosphatidylinositol-specific phospholipase C in survival and virulence of Cryptococcus neoformans.

Chayakulkeeree M, Sorrell TC, Siafakas AR, Wilson CF, Pantarat N, Gerik KJ, Boadle R, Djordjevic JT.

Mol Microbiol. 2008 Aug;69(4):809-26. doi: 10.1111/j.1365-2958.2008.06310.x. Epub 2008 Jun 4.

PMID:
18532984
[PubMed - indexed for MEDLINE]
16.
17.

Heteroresistance of Cryptococcus gattii to fluconazole.

Varma A, Kwon-Chung KJ.

Antimicrob Agents Chemother. 2010 Jun;54(6):2303-11. doi: 10.1128/AAC.00153-10. Epub 2010 Apr 12.

PMID:
20385871
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Calcineurin, Mpk1 and Hog1 MAPK pathways independently control fludioxonil antifungal sensitivity in Cryptococcus neoformans.

Kojima K, Bahn YS, Heitman J.

Microbiology. 2006 Mar;152(Pt 3):591-604.

PMID:
16514140
[PubMed - indexed for MEDLINE]
Free Article
19.

Deletion of Cryptococcus neoformans AIF ortholog promotes chromosome aneuploidy and fluconazole-resistance in a metacaspase-independent manner.

Semighini CP, Averette AF, Perfect JR, Heitman J.

PLoS Pathog. 2011 Nov;7(11):e1002364. doi: 10.1371/journal.ppat.1002364. Epub 2011 Nov 17.

PMID:
22114551
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

The vacuolar Ca²(+) exchanger Vcx1 is involved in calcineurin-dependent Ca²(+) tolerance and virulence in Cryptococcus neoformans.

Kmetzsch L, Staats CC, Simon E, Fonseca FL, de Oliveira DL, Sobrino L, Rodrigues J, Leal AL, Nimrichter L, Rodrigues ML, Schrank A, Vainstein MH.

Eukaryot Cell. 2010 Nov;9(11):1798-805. doi: 10.1128/EC.00114-10. Epub 2010 Oct 1.

PMID:
20889719
[PubMed - indexed for MEDLINE]
Free PMC Article

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