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Items: 1 to 20 of 126

1.

Comparison of random mutagenesis and semi-rational designed libraries for improved cytochrome P450 BM3-catalyzed hydroxylation of small alkanes.

Chen MM, Snow CD, Vizcarra CL, Mayo SL, Arnold FH.

Protein Eng Des Sel. 2012 Apr;25(4):171-8. doi: 10.1093/protein/gzs004. Epub 2012 Feb 14.

2.

Hydroxylation of non-substituted polycyclic aromatic hydrocarbons by cytochrome P450 BM3 engineered by directed evolution.

Sideri A, Goyal A, Di Nardo G, Tsotsou GE, Gilardi G.

J Inorg Biochem. 2013 Mar;120:1-7. doi: 10.1016/j.jinorgbio.2012.11.007. Epub 2012 Dec 3.

PMID:
23262457
3.

Cytochrome P450 BM-3 evolved by random and saturation mutagenesis as an effective indole-hydroxylating catalyst.

Li HM, Mei LH, Urlacher VB, Schmid RD.

Appl Biochem Biotechnol. 2008 Jan;144(1):27-36.

PMID:
18415984
4.
6.

Molecular Lego: design of molecular assemblies of P450 enzymes for nanobiotechnology.

Gilardi G, Meharenna YT, Tsotsou GE, Sadeghi SJ, Fairhead M, Giannini S.

Biosens Bioelectron. 2002 Jan;17(1-2):133-45.

PMID:
11742744
7.

Regio- and enantioselective alkane hydroxylation with engineered cytochromes P450 BM-3.

Peters MW, Meinhold P, Glieder A, Arnold FH.

J Am Chem Soc. 2003 Nov 5;125(44):13442-50.

PMID:
14583039
8.

Site-directed mutagenesis of the putative distal helix of peroxygenase cytochrome P450.

Matsunaga I, Ueda A, Sumimoto T, Ichihara K, Ayata M, Ogura H.

Arch Biochem Biophys. 2001 Oct 1;394(1):45-53.

PMID:
11566026
9.

A single mutation in cytochrome P450 BM3 changes substrate orientation in a catalytic intermediate and the regiospecificity of hydroxylation.

Oliver CF, Modi S, Sutcliffe MJ, Primrose WU, Lian LY, Roberts GC.

Biochemistry. 1997 Feb 18;36(7):1567-72.

PMID:
9048540
10.

Screening of a minimal enriched P450 BM3 mutant library for hydroxylation of cyclic and acyclic alkanes.

Weber E, Seifert A, Antonovici M, Geinitz C, Pleiss J, Urlacher VB.

Chem Commun (Camb). 2011 Jan 21;47(3):944-6. doi: 10.1039/c0cc02924f. Epub 2010 Nov 15.

PMID:
21079837
11.
12.

Active site substitution A82W improves the regioselectivity of steroid hydroxylation by cytochrome P450 BM3 mutants as rationalized by spin relaxation nuclear magnetic resonance studies.

Rea V, Kolkman AJ, Vottero E, Stronks EJ, Ampt KA, Honing M, Vermeulen NP, Wijmenga SS, Commandeur JN.

Biochemistry. 2012 Jan 24;51(3):750-60. doi: 10.1021/bi201433h. Epub 2012 Jan 12.

PMID:
22208729
13.

Laboratory evolution of P450 BM3 for mediated electron transfer yielding an activity-improved and reductase-independent variant.

Nazor J, Dannenmann S, Adjei RO, Fordjour YB, Ghampson IT, Blanusa M, Roccatano D, Schwaneberg U.

Protein Eng Des Sel. 2008 Jan;21(1):29-35. Epub 2007 Dec 19.

14.

Efficient screening of cytochrome P450 BM3 mutants for their metabolic activity and diversity toward a wide set of drug-like molecules in chemical space.

Reinen J, van Leeuwen JS, Li Y, Sun L, Grootenhuis PD, Decker CJ, Saunders J, Vermeulen NP, Commandeur JN.

Drug Metab Dispos. 2011 Sep;39(9):1568-76. doi: 10.1124/dmd.111.039461. Epub 2011 Jun 14.

15.

Alkane hydroxylation by peroxy acids: a comparison with the cytochrome P450 hydroxylation.

Groenhof AR, Ehlers AW, Lammertsma K.

J Phys Chem A. 2008 Dec 18;112(50):12855-61. doi: 10.1021/jp801720s.

PMID:
18956858
16.

An efficient route to selective bio-oxidation catalysts: an iterative approach comprising modeling, diversification, and screening, based on CYP102A1.

Seifert A, Antonovici M, Hauer B, Pleiss J.

Chembiochem. 2011 Jun 14;12(9):1346-51. doi: 10.1002/cbic.201100067. Epub 2011 May 17.

PMID:
21591046
17.

Optimization of combinatorial mutagenesis.

Parker AS, Griswold KE, Bailey-Kellogg C.

J Comput Biol. 2011 Nov;18(11):1743-56. doi: 10.1089/cmb.2011.0152. Epub 2011 Sep 16.

PMID:
21923411
18.

A single active site mutation inverts stereoselectivity of 16-hydroxylation of testosterone catalyzed by engineered cytochrome P450 BM3.

Venkataraman H, Beer SB, Bergen LA, Essen Nv, Geerke DP, Vermeulen NP, Commandeur JN.

Chembiochem. 2012 Mar 5;13(4):520-3. doi: 10.1002/cbic.201100750. Epub 2012 Jan 24.

PMID:
22275147
19.
20.

Changing the regioselectivity of a P450 from C15 to C11 hydroxylation of progesterone.

Nguyen KT, Virus C, Günnewich N, Hannemann F, Bernhardt R.

Chembiochem. 2012 May 29;13(8):1161-6. doi: 10.1002/cbic.201100811. Epub 2012 Apr 24.

PMID:
22532270
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