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Items: 1 to 20 of 245

1.

Topical ocular sodium 4-phenylbutyrate rescues glaucoma in a myocilin mouse model of primary open-angle glaucoma.

Zode GS, Bugge KE, Mohan K, Grozdanic SD, Peters JC, Koehn DR, Anderson MG, Kardon RH, Stone EM, Sheffield VC.

Invest Ophthalmol Vis Sci. 2012 Mar 21;53(3):1557-65. doi: 10.1167/iovs.11-8837. Print 2012 Mar.

2.

Reduction of ER stress via a chemical chaperone prevents disease phenotypes in a mouse model of primary open angle glaucoma.

Zode GS, Kuehn MH, Nishimura DY, Searby CC, Mohan K, Grozdanic SD, Bugge K, Anderson MG, Clark AF, Stone EM, Sheffield VC.

J Clin Invest. 2011 Sep;121(9):3542-53. doi: 10.1172/JCI58183. Epub 2011 Aug 8. Erratum in: J Clin Invest. 2015 Aug 3;125(8):3303.

3.

Mutant human myocilin induces strain specific differences in ocular hypertension and optic nerve damage in mice.

McDowell CM, Luan T, Zhang Z, Putliwala T, Wordinger RJ, Millar JC, John SW, Pang IH, Clark AF.

Exp Eye Res. 2012 Jul;100:65-72. doi: 10.1016/j.exer.2012.04.016. Epub 2012 May 3.

4.
5.

Targeting the ER-autophagy system in the trabecular meshwork to treat glaucoma.

Stothert AR, Fontaine SN, Sabbagh JJ, Dickey CA.

Exp Eye Res. 2016 Mar;144:38-45. doi: 10.1016/j.exer.2015.08.017. Epub 2015 Aug 22. Review.

PMID:
26302411
6.

Non-secretion of mutant proteins of the glaucoma gene myocilin in cultured trabecular meshwork cells and in aqueous humor.

Jacobson N, Andrews M, Shepard AR, Nishimura D, Searby C, Fingert JH, Hageman G, Mullins R, Davidson BL, Kwon YH, Alward WL, Stone EM, Clark AF, Sheffield VC.

Hum Mol Genet. 2001 Jan 15;10(2):117-25.

7.

Intracellular sequestration of hetero-oligomers formed by wild-type and glaucoma-causing myocilin mutants.

Gobeil S, Rodrigue MA, Moisan S, Nguyen TD, Polansky JR, Morissette J, Raymond V.

Invest Ophthalmol Vis Sci. 2004 Oct;45(10):3560-7.

PMID:
15452063
8.

Elevated amounts of myocilin in the aqueous humor of transgenic mice cause significant changes in ocular gene expression.

Paper W, Kroeber M, Heersink S, Stephan DA, Fuchshofer R, Russell P, Tamm ER.

Exp Eye Res. 2008 Sep;87(3):257-67. doi: 10.1016/j.exer.2008.06.006. Epub 2008 Jun 17.

9.

Aqueous humor myocilin protein levels in normal, genetic carriers, and glaucoma Beagles.

Mackay EO, Källberg ME, Gelatt KN.

Vet Ophthalmol. 2008 May-Jun;11(3):177-85. doi: 10.1111/j.1463-5224.2008.00617.x.

PMID:
18435660
10.

Sodium 4-phenylbutyrate acts as a chemical chaperone on misfolded myocilin to rescue cells from endoplasmic reticulum stress and apoptosis.

Yam GH, Gaplovska-Kysela K, Zuber C, Roth J.

Invest Ophthalmol Vis Sci. 2007 Apr;48(4):1683-90.

PMID:
17389500
11.

Overexpression and properties of wild-type and Tyr437His mutated myocilin in the eyes of transgenic mice.

Zillig M, Wurm A, Grehn FJ, Russell P, Tamm ER.

Invest Ophthalmol Vis Sci. 2005 Jan;46(1):223-34.

PMID:
15623777
12.

Immunolocalization of myocilin protein in the anterior eye of normal and primary open-angle glaucomatous dogs.

Hart H, Samuelson DA, Tajwar H, MacKay EO, Lewis PA, Kallberg M, Gelatt KN.

Vet Ophthalmol. 2007 Nov-Dec;10 Suppl 1:28-37.

PMID:
17973832
13.

A review of genetic and structural understanding of the role of myocilin in primary open angle glaucoma.

Kanagavalli J, Pandaranayaka E, Krishnadas SR, Krishnaswamy S, Sundaresan P.

Indian J Ophthalmol. 2004 Dec;52(4):271-80. Review.

14.

Expression of mutated mouse myocilin induces open-angle glaucoma in transgenic mice.

Senatorov V, Malyukova I, Fariss R, Wawrousek EF, Swaminathan S, Sharan SK, Tomarev S.

J Neurosci. 2006 Nov 15;26(46):11903-14.

15.

Evaluation of the myocilin (MYOC) glaucoma gene in monkey and human steroid-induced ocular hypertension.

Fingert JH, Clark AF, Craig JE, Alward WL, Snibson GR, McLaughlin M, Tuttle L, Mackey DA, Sheffield VC, Stone EM.

Invest Ophthalmol Vis Sci. 2001 Jan;42(1):145-52.

PMID:
11133859
16.

Myocilin in the trabecular meshwork of eyes with primary open-angle glaucoma.

Konz DD, Flügel-Koch C, Ohlmann A, Tamm ER.

Graefes Arch Clin Exp Ophthalmol. 2009 Dec;247(12):1643-9. doi: 10.1007/s00417-009-1152-0. Epub 2009 Aug 7.

PMID:
19662433
17.

Myocilin protein levels in the aqueous humor of the glaucomas in selected canine breeds.

MacKay EO, Kallberg ME, Barrie KP, Miller W, Sapienza JS, Denis H, Ollivier FJ, Plummer C, Rinkoski T, Scotty N, Gelatt KN.

Vet Ophthalmol. 2008 Jul-Aug;11(4):234-41. doi: 10.1111/j.1463-5224.2008.00631.x.

PMID:
18638349
19.

Keeping an eye on myocilin: a complex molecule associated with primary open-angle glaucoma susceptibility.

Menaa F, Braghini CA, Vasconcellos JP, Menaa B, Costa VP, Figueiredo ES, Melo MB.

Molecules. 2011 Jun 27;16(7):5402-21. doi: 10.3390/molecules16075402. Review.

20.

Mutant myocilin nonsecretion in vivo is not sufficient to cause glaucoma.

Gould DB, Reedy M, Wilson LA, Smith RS, Johnson RL, John SW.

Mol Cell Biol. 2006 Nov;26(22):8427-36. Epub 2006 Sep 5.

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