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Items: 1 to 20 of 81


Stereospecific formation of a ternary complex of (S)-α,β-fluoromethylene-dATP with DNA pol β.

Chamberlain BT, Batra VK, Beard WA, Kadina AP, Shock DD, Kashemirov BA, McKenna CE, Goodman MF, Wilson SH.

Chembiochem. 2012 Mar 5;13(4):528-30. doi: 10.1002/cbic.201100738. Epub 2012 Feb 7.


Halogenated beta,gamma-methylene- and ethylidene-dGTP-DNA ternary complexes with DNA polymerase beta: structural evidence for stereospecific binding of the fluoromethylene analogues.

Batra VK, Pedersen LC, Beard WA, Wilson SH, Kashemirov BA, Upton TG, Goodman MF, McKenna CE.

J Am Chem Soc. 2010 Jun 9;132(22):7617-25. doi: 10.1021/ja909370k.


Differing conformational pathways before and after chemistry for insertion of dATP versus dCTP opposite 8-oxoG in DNA polymerase beta.

Wang Y, Reddy S, Beard WA, Wilson SH, Schlick T.

Biophys J. 2007 May 1;92(9):3063-70. Epub 2007 Feb 9.


Alpha,beta-difluoromethylene deoxynucleoside 5'-triphosphates: a convenient synthesis of useful probes for DNA polymerase beta structure and function.

Upton TG, Kashemirov BA, McKenna CE, Goodman MF, Prakash GK, Kultyshev R, Batra VK, Shock DD, Pedersen LC, Beard WA, Wilson SH.

Org Lett. 2009 May 7;11(9):1883-6. doi: 10.1021/ol701755k.


(R)-beta,gamma-fluoromethylene-dGTP-DNA ternary complex with DNA polymerase beta.

McKenna CE, Kashemirov BA, Upton TG, Batra VK, Goodman MF, Pedersen LC, Beard WA, Wilson SH.

J Am Chem Soc. 2007 Dec 19;129(50):15412-3. Epub 2007 Nov 22. No abstract available.


A structural basis for metal ion mutagenicity and nucleotide selectivity in human DNA polymerase beta.

Pelletier H, Sawaya MR, Wolfle W, Wilson SH, Kraut J.

Biochemistry. 1996 Oct 1;35(39):12762-77.


Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization.

Fairman JW, Wijerathna SR, Ahmad MF, Xu H, Nakano R, Jha S, Prendergast J, Welin RM, Flodin S, Roos A, Nordlund P, Li Z, Walz T, Dealwis CG.

Nat Struct Mol Biol. 2011 Mar;18(3):316-22. doi: 10.1038/nsmb.2007. Epub 2011 Feb 20.


Characterization of the active site of DNA polymerase beta by molecular dynamics and quantum chemical calculation.

Rittenhouse RC, Apostoluk WK, Miller JH, Straatsma TP.

Proteins. 2003 Nov 15;53(3):667-82.


Effect of β,γ-CHF- and β,γ-CHCl-dGTP halogen atom stereochemistry on the transition state of DNA polymerase β.

Oertell K, Wu Y, Zakharova VM, Kashemirov BA, Shock DD, Beard WA, Wilson SH, McKenna CE, Goodman MF.

Biochemistry. 2012 Oct 30;51(43):8491-501. doi: 10.1021/bi3010335. Epub 2012 Oct 19.


Mechanism of template-independent nucleotide incorporation catalyzed by a template-dependent DNA polymerase.

Fiala KA, Brown JA, Ling H, Kshetry AK, Zhang J, Taylor JS, Yang W, Suo Z.

J Mol Biol. 2007 Jan 19;365(3):590-602. Epub 2006 Oct 7.


Kinetic mechanism of active site assembly and chemical catalysis of DNA polymerase β.

Balbo PB, Wang EC, Tsai MD.

Biochemistry. 2011 Nov 15;50(45):9865-75. doi: 10.1021/bi200954r. Epub 2011 Oct 19.


Insight into the catalytic mechanism of DNA polymerase beta: structures of intermediate complexes.

Arndt JW, Gong W, Zhong X, Showalter AK, Liu J, Dunlap CA, Lin Z, Paxson C, Tsai MD, Chan MK.

Biochemistry. 2001 May 8;40(18):5368-75.


Structure of yeast poly(A) polymerase alone and in complex with 3'-dATP.

Bard J, Zhelkovsky AM, Helmling S, Earnest TN, Moore CL, Bohm A.

Science. 2000 Aug 25;289(5483):1346-9.


Y-Family DNA polymerases may use two different dNTP shapes for insertion: a hypothesis and its implications.

Chandani S, Loechler EL.

J Mol Graph Model. 2009 Apr;27(7):759-69. doi: 10.1016/j.jmgm.2008.11.003. Epub 2008 Nov 8.


A structural solution for the DNA polymerase lambda-dependent repair of DNA gaps with minimal homology.

Garcia-Diaz M, Bebenek K, Krahn JM, Blanco L, Kunkel TA, Pedersen LC.

Mol Cell. 2004 Feb 27;13(4):561-72.

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