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Results: 1 to 20 of 103

1.

Probing chelation motifs in HIV integrase inhibitors.

Agrawal A, DeSoto J, Fullagar JL, Maddali K, Rostami S, Richman DD, Pommier Y, Cohen SM.

Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2251-6. doi: 10.1073/pnas.1112389109. Epub 2012 Jan 27.

PMID:
22308350
[PubMed - indexed for MEDLINE]
Free PMC Article
2.
3.

Exploring the molecular mechanism of cross-resistance to HIV-1 integrase strand transfer inhibitors by molecular dynamics simulation and residue interaction network analysis.

Xue W, Jin X, Ning L, Wang M, Liu H, Yao X.

J Chem Inf Model. 2013 Jan 28;53(1):210-22. doi: 10.1021/ci300541c. Epub 2012 Dec 20.

PMID:
23231029
[PubMed - indexed for MEDLINE]
4.

2-Hydroxyisoquinoline-1,3(2H,4H)-diones (HIDs), novel inhibitors of HIV integrase with a high barrier to resistance.

Desimmie BA, Demeulemeester J, Suchaud V, Taltynov O, Billamboz M, Lion C, Bailly F, Strelkov SV, Debyser Z, Cotelle P, Christ F.

ACS Chem Biol. 2013;8(6):1187-94. doi: 10.1021/cb4000426. Epub 2013 Apr 2.

PMID:
23517458
[PubMed - indexed for MEDLINE]
5.

New chloro,fluorobenzylindole derivatives as integrase strand-transfer inhibitors (INSTIs) and their mode of action.

Ferro S, De Luca L, Barreca ML, De Grazia S, Christ F, Debyser Z, Chimirri A.

Bioorg Med Chem. 2010 Aug 1;18(15):5510-8. doi: 10.1016/j.bmc.2010.06.063. Epub 2010 Jun 22.

PMID:
20630765
[PubMed - indexed for MEDLINE]
6.

Dihydroxythiophenes are novel potent inhibitors of human immunodeficiency virus integrase with a diketo acid-like pharmacophore.

Kehlenbeck S, Betz U, Birkmann A, Fast B, Göller AH, Henninger K, Lowinger T, Marrero D, Paessens A, Paulsen D, Pevzner V, Schohe-Loop R, Tsujishita H, Welker R, Kreuter J, Rübsamen-Waigmann H, Dittmer F.

J Virol. 2006 Jul;80(14):6883-94.

PMID:
16809294
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Small-molecule inhibitors of the LEDGF/p75 binding site of integrase block HIV replication and modulate integrase multimerization.

Christ F, Shaw S, Demeulemeester J, Desimmie BA, Marchand A, Butler S, Smets W, Chaltin P, Westby M, Debyser Z, Pickford C.

Antimicrob Agents Chemother. 2012 Aug;56(8):4365-74. doi: 10.1128/AAC.00717-12. Epub 2012 Jun 4.

PMID:
22664975
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Bicyclic hydroxy-1H-pyrrolopyridine-trione containing HIV-1 integrase inhibitors.

Zhao XZ, Maddali K, Metifiot M, Smith SJ, Vu BC, Marchand C, Hughes SH, Pommier Y, Burke TR Jr.

Chem Biol Drug Des. 2012 Feb;79(2):157-65. doi: 10.1111/j.1747-0285.2011.01270.x. Epub 2011 Dec 22.

PMID:
22107736
[PubMed - indexed for MEDLINE]
9.

Investigating the role of metal chelation in HIV-1 integrase strand transfer inhibitors.

Bacchi A, Carcelli M, Compari C, Fisicaro E, Pala N, Rispoli G, Rogolino D, Sanchez TW, Sechi M, Sinisi V, Neamati N.

J Med Chem. 2011 Dec 22;54(24):8407-20. doi: 10.1021/jm200851g. Epub 2011 Nov 22.

PMID:
22066494
[PubMed - indexed for MEDLINE]
10.

Characterization of the R263K mutation in HIV-1 integrase that confers low-level resistance to the second-generation integrase strand transfer inhibitor dolutegravir.

Quashie PK, Mesplède T, Han YS, Oliveira M, Singhroy DN, Fujiwara T, Underwood MR, Wainberg MA.

J Virol. 2012 Mar;86(5):2696-705. doi: 10.1128/JVI.06591-11. Epub 2011 Dec 28.

PMID:
22205735
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Authentic HIV-1 integrase inhibitors.

Liao C, Marchand C, Burke TR Jr, Pommier Y, Nicklaus MC.

Future Med Chem. 2010 Jul;2(7):1107-22. doi: 10.4155/fmc.10.199. Review.

PMID:
21426159
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Induced-fit docking approach provides insight into the binding mode and mechanism of action of HIV-1 integrase inhibitors.

Barreca ML, Iraci N, De Luca L, Chimirri A.

ChemMedChem. 2009 Sep;4(9):1446-56. doi: 10.1002/cmdc.200900166.

PMID:
19544345
[PubMed - indexed for MEDLINE]
13.

Binding mode prediction of strand transfer HIV-1 integrase inhibitors using Tn5 transposase as a plausible surrogate model for HIV-1 integrase.

Barreca ML, De Luca L, Iraci N, Chimirri A.

J Med Chem. 2006 Jun 29;49(13):3994-7.

PMID:
16789757
[PubMed - indexed for MEDLINE]
14.

Diketo acid inhibitor mechanism and HIV-1 integrase: implications for metal binding in the active site of phosphotransferase enzymes.

Grobler JA, Stillmock K, Hu B, Witmer M, Felock P, Espeseth AS, Wolfe A, Egbertson M, Bourgeois M, Melamed J, Wai JS, Young S, Vacca J, Hazuda DJ.

Proc Natl Acad Sci U S A. 2002 May 14;99(10):6661-6. Epub 2002 May 7.

PMID:
11997448
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Novel therapeutic strategies targeting HIV integrase.

Quashie PK, Sloan RD, Wainberg MA.

BMC Med. 2012 Apr 12;10:34. doi: 10.1186/1741-7015-10-34. Review.

PMID:
22498430
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Dissecting Tn5 transposition using HIV-1 integrase diketoacid inhibitors.

Czyz A, Stillmock KA, Hazuda DJ, Reznikoff WS.

Biochemistry. 2007 Sep 25;46(38):10776-89. Epub 2007 Aug 29.

PMID:
17725323
[PubMed - indexed for MEDLINE]
17.

The future of integrase inhibitors of HIV-1.

Malet I, Calvez V, Marcelin AG.

Curr Opin Virol. 2012 Oct;2(5):580-7. doi: 10.1016/j.coviro.2012.08.005. Epub 2012 Sep 12. Review.

PMID:
22980926
[PubMed - indexed for MEDLINE]
18.

In Vitro antiretroviral properties of S/GSK1349572, a next-generation HIV integrase inhibitor.

Kobayashi M, Yoshinaga T, Seki T, Wakasa-Morimoto C, Brown KW, Ferris R, Foster SA, Hazen RJ, Miki S, Suyama-Kagitani A, Kawauchi-Miki S, Taishi T, Kawasuji T, Johns BA, Underwood MR, Garvey EP, Sato A, Fujiwara T.

Antimicrob Agents Chemother. 2011 Feb;55(2):813-21. doi: 10.1128/AAC.01209-10. Epub 2010 Nov 29.

PMID:
21115794
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

De novo design and synthesis of HIV-1 integrase inhibitors.

Makhija MT, Kasliwal RT, Kulkarni VM, Neamati N.

Bioorg Med Chem. 2004 May 1;12(9):2317-33.

PMID:
15080929
[PubMed - indexed for MEDLINE]
20.

Resistance to raltegravir highlights integrase mutations at codon 148 in conferring cross-resistance to a second-generation HIV-1 integrase inhibitor.

Goethals O, Van Ginderen M, Vos A, Cummings MD, Van Der Borght K, Van Wesenbeeck L, Feyaerts M, Verheyen A, Smits V, Van Loock M, Hertogs K, Schols D, Clayton RF.

Antiviral Res. 2011 Aug;91(2):167-76. doi: 10.1016/j.antiviral.2011.05.011. Epub 2011 Jun 12.

PMID:
21669228
[PubMed - indexed for MEDLINE]
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