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Results: 1 to 20 of 101

1.

Polycyclic cage structures as lipophilic scaffolds for neuroactive drugs.

Joubert J, Geldenhuys WJ, Van der Schyf CJ, Oliver DW, Kruger HG, Govender T, Malan SF.

ChemMedChem. 2012 Mar 5;7(3):375-84. doi: 10.1002/cmdc.201100559. Epub 2012 Feb 3. Review.

PMID:
22307951
[PubMed - indexed for MEDLINE]
2.

Fluorescent polycyclic ligands for nitric oxide synthase (NOS) inhibition.

Joubert J, van Dyk S, Malan SF.

Bioorg Med Chem. 2008 Oct 1;16(19):8952-8. doi: 10.1016/j.bmc.2008.08.049. Epub 2008 Aug 27.

PMID:
18805011
[PubMed - indexed for MEDLINE]
3.

Synthesis and in vitro evaluation of pteridine analogues as monoamine oxidase B and nitric oxide synthase inhibitors.

Prins LH, Petzer JP, Malan SF.

Bioorg Med Chem. 2009 Nov 1;17(21):7523-30. doi: 10.1016/j.bmc.2009.09.019. Epub 2009 Sep 15.

PMID:
19804982
[PubMed - indexed for MEDLINE]
4.

Multifunctional neuroprotective drugs targeting monoamine oxidase inhibition, iron chelation, adenosine receptors, and cholinergic and glutamatergic action for neurodegenerative diseases.

Van der Schyf CJ, Gal S, Geldenhuys WJ, Youdim MB.

Expert Opin Investig Drugs. 2006 Aug;15(8):873-86. Review.

PMID:
16859391
[PubMed - indexed for MEDLINE]
5.

Novel bifunctional drugs targeting monoamine oxidase inhibition and iron chelation as an approach to neuroprotection in Parkinson's disease and other neurodegenerative diseases.

Youdim MB, Fridkin M, Zheng H.

J Neural Transm. 2004 Oct;111(10-11):1455-71. Epub 2004 Apr 20.

PMID:
15480846
[PubMed - indexed for MEDLINE]
6.

Pharmacology and structure-activity relationships of bioactive polycyclic cage compounds: a focus on pentacycloundecane derivatives.

Geldenhuys WJ, Malan SF, Bloomquist JR, Marchand AP, Van der Schyf CJ.

Med Res Rev. 2005 Jan;25(1):21-48. Review.

PMID:
15389731
[PubMed - indexed for MEDLINE]
7.

Rationally designed multi-targeted agents against neurodegenerative diseases.

Geldenhuys WJ, Van der Schyf CJ.

Curr Med Chem. 2013;20(13):1662-72. Review.

PMID:
23410161
[PubMed - indexed for MEDLINE]
9.

Dual-target-directed drugs that block monoamine oxidase B and adenosine A(2A) receptors for Parkinson's disease.

Petzer JP, Castagnoli N Jr, Schwarzschild MA, Chen JF, Van der Schyf CJ.

Neurotherapeutics. 2009 Jan;6(1):141-51. doi: 10.1016/j.nurt.2008.10.035. Review.

PMID:
19110205
[PubMed - indexed for MEDLINE]
10.

Monoamine oxidase inhibitors as neuroprotective agents in age-dependent neurodegenerative disorders.

Naoi M, Maruyama W.

Curr Pharm Des. 2010;16(25):2799-817. Review.

PMID:
20698822
[PubMed - indexed for MEDLINE]
12.

Synthesis and pharmacological evaluation of N-(2,5-disubstituted phenyl)-N'-(3-substituted phenyl)-N'-methylguanidines as N-methyl-D-aspartate receptor ion-channel blockers.

Hu LY, Guo J, Magar SS, Fischer JB, Burke-Howie KJ, Durant GJ.

J Med Chem. 1997 Dec 19;40(26):4281-9. Erratum in: J Med Chem 1998 Mar 12;41(6):1006.

PMID:
9435897
[PubMed - indexed for MEDLINE]
13.

Synthesis and evaluation of fluorescent heterocyclic aminoadamantanes as multifunctional neuroprotective agents.

Joubert J, van Dyk S, Green IR, Malan SF.

Bioorg Med Chem. 2011 Jul 1;19(13):3935-44. doi: 10.1016/j.bmc.2011.05.034. Epub 2011 May 24.

PMID:
21665485
[PubMed - indexed for MEDLINE]
14.

New therapeutic strategy for Parkinson's and Alzheimer's disease.

Esposito E, Cuzzocrea S.

Curr Med Chem. 2010;17(25):2764-74. Review.

PMID:
20586718
[PubMed - indexed for MEDLINE]
15.

Fluorinated molecules in the diagnosis and treatment of neurodegenerative diseases.

Gaye B, Adejare A.

Future Med Chem. 2009 Aug;1(5):821-33. doi: 10.4155/fmc.09.85. Review.

PMID:
21426082
[PubMed - indexed for MEDLINE]
16.

Dementia of Alzheimer's disease and other neurodegenerative disorders--memantine, a new hope.

Sonkusare SK, Kaul CL, Ramarao P.

Pharmacol Res. 2005 Jan;51(1):1-17. Review.

PMID:
15519530
[PubMed - indexed for MEDLINE]
17.

Kynurenines in chronic neurodegenerative disorders: future therapeutic strategies.

Zádori D, Klivényi P, Vámos E, Fülöp F, Toldi J, Vécsei L.

J Neural Transm. 2009 Nov;116(11):1403-9. doi: 10.1007/s00702-009-0263-4. Epub 2009 Jul 18. Review.

PMID:
19618107
[PubMed - indexed for MEDLINE]
18.
19.

Polycyclic propargylamine and acetylene derivatives as multifunctional neuroprotective agents.

Zindo FT, Barber QR, Joubert J, Bergh JJ, Petzer JP, Malan SF.

Eur J Med Chem. 2014 Jun 10;80:122-34. doi: 10.1016/j.ejmech.2014.04.039. Epub 2014 Apr 13.

PMID:
24769350
[PubMed - in process]
20.

Structure-activity relationships of pentacycloundecylamines at the N-methyl-d-aspartate receptor.

Geldenhuys WJ, Malan SF, Bloomquist JR, Van der Schyf CJ.

Bioorg Med Chem. 2007 Feb 1;15(3):1525-32. Epub 2006 Sep 29.

PMID:
17157509
[PubMed - indexed for MEDLINE]

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