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Results: 1 to 20 of 161

1.

The amyloid-β isoform pattern in cerebrospinal fluid in familial PSEN1 M139T- and L286P-associated Alzheimer's disease.

Portelius E, Fortea J, Molinuevo JL, Gustavsson MK, Andreasson U, Sanchez-Valle R.

Mol Med Rep. 2012 Apr;5(4):1111-5. doi: 10.3892/mmr.2012.774. Epub 2012 Feb 1.

PMID:
22307680
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Distinct cerebrospinal fluid amyloid beta peptide signatures in sporadic and PSEN1 A431E-associated familial Alzheimer's disease.

Portelius E, Andreasson U, Ringman JM, Buerger K, Daborg J, Buchhave P, Hansson O, Harmsen A, Gustavsson MK, Hanse E, Galasko D, Hampel H, Blennow K, Zetterberg H.

Mol Neurodegener. 2010 Jan 14;5:2. doi: 10.1186/1750-1326-5-2.

PMID:
20145736
[PubMed]
Free PMC Article
3.

Effects of gamma-secretase inhibition on the amyloid beta isoform pattern in a mouse model of Alzheimer's disease.

Portelius E, Zhang B, Gustavsson MK, Brinkmalm G, Westman-Brinkmalm A, Zetterberg H, Lee VM, Trojanowski JQ, Blennow K.

Neurodegener Dis. 2009;6(5-6):258-62. doi: 10.1159/000264639. Epub 2009 Dec 3.

PMID:
19955704
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Identification of novel APP/Abeta isoforms in human cerebrospinal fluid.

Portelius E, Brinkmalm G, Tran AJ, Zetterberg H, Westman-Brinkmalm A, Blennow K.

Neurodegener Dis. 2009;6(3):87-94. doi: 10.1159/000203774. Epub 2009 Feb 20.

PMID:
19229112
[PubMed - indexed for MEDLINE]
5.

Elevation of beta-amyloid peptide 2-42 in sporadic and familial Alzheimer's disease and its generation in PS1 knockout cells.

Wiltfang J, Esselmann H, Cupers P, Neumann M, Kretzschmar H, Beyermann M, Schleuder D, Jahn H, Rüther E, Kornhuber J, Annaert W, De Strooper B, Saftig P.

J Biol Chem. 2001 Nov 16;276(46):42645-57. Epub 2001 Aug 28.

PMID:
11526104
[PubMed - indexed for MEDLINE]
Free Article
6.

γ-secretase binding sites in aged and Alzheimer's disease human cerebrum: the choroid plexus as a putative origin of CSF Aβ.

Liu F, Xue ZQ, Deng SH, Kun X, Luo XG, Patrylo PR, Rose GM, Cai H, Struble RG, Cai Y, Yan XX.

Eur J Neurosci. 2013 May;37(10):1714-25. doi: 10.1111/ejn.12159. Epub 2013 Feb 22. Erratum in: Eur J Neurosci. 2013 Jul;38(2):2340.

PMID:
23432732
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Amino-terminally truncated Abeta peptide species are the main component of cotton wool plaques.

Miravalle L, Calero M, Takao M, Roher AE, Ghetti B, Vidal R.

Biochemistry. 2005 Aug 16;44(32):10810-21.

PMID:
16086583
[PubMed - indexed for MEDLINE]
8.

Evaluation of the performance of novel Aβ isoforms as theragnostic markers in Alzheimer's disease: from the cell to the patient.

Portelius E, Gustavsson MK, Zetterberg H, Andreasson U, Blennow K.

Neurodegener Dis. 2012;10(1-4):138-40. doi: 10.1159/000334537. Epub 2012 Feb 1. Review.

PMID:
22302034
[PubMed - indexed for MEDLINE]
9.

Mass spectrometric characterization of brain amyloid beta isoform signatures in familial and sporadic Alzheimer's disease.

Portelius E, Bogdanovic N, Gustavsson MK, Volkmann I, Brinkmalm G, Zetterberg H, Winblad B, Blennow K.

Acta Neuropathol. 2010 Aug;120(2):185-93. doi: 10.1007/s00401-010-0690-1. Epub 2010 Apr 24.

PMID:
20419305
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Novel aβ isoforms in Alzheimer's disease - their role in diagnosis and treatment.

Portelius E, Mattsson N, Andreasson U, Blennow K, Zetterberg H.

Curr Pharm Des. 2011;17(25):2594-602. Review.

PMID:
21728980
[PubMed - indexed for MEDLINE]
11.

An Alzheimer's disease-specific beta-amyloid fragment signature in cerebrospinal fluid.

Portelius E, Zetterberg H, Andreasson U, Brinkmalm G, Andreasen N, Wallin A, Westman-Brinkmalm A, Blennow K.

Neurosci Lett. 2006 Dec 6;409(3):215-9. Epub 2006 Oct 17.

PMID:
17049739
[PubMed - indexed for MEDLINE]
12.

PSEN1 mutation carriers present lower cerebrospinal fluid amyoid-β42 levels than sporadic early-onset Alzheimer's disease patients but no differences in neuronal injury biomarkers.

Balasa M, Vidal-Piñeiro D, Lladó A, Antonell A, Bosch B, Castellanos F, Bargalló N, Bartres-Faz D, Molinuevo JL, Sánchez-Valle R.

J Alzheimers Dis. 2012;30(3):605-16. doi: 10.3233/JAD-2012-111949.

PMID:
22426017
[PubMed - indexed for MEDLINE]
13.

γ-Secretase processing and effects of γ-secretase inhibitors and modulators on long Aβ peptides in cells.

Ran Y, Cruz PE, Ladd TB, Fauq AH, Jung JI, Matthews J, Felsenstein KM, Golde TE.

J Biol Chem. 2014 Feb 7;289(6):3276-87. doi: 10.1074/jbc.M113.512921. Epub 2013 Dec 18.

PMID:
24352661
[PubMed - indexed for MEDLINE]
14.
15.

Presenilin-1 280Glu-->Ala mutation alters C-terminal APP processing yielding longer abeta peptides: implications for Alzheimer's disease.

Van Vickle GD, Esh CL, Kokjohn TA, Patton RL, Kalback WM, Luehrs DC, Beach TG, Newel AJ, Lopera F, Ghetti B, Vidal R, Castaño EM, Roher AE.

Mol Med. 2008 Mar-Apr;14(3-4):184-94. doi: 10.2119/2007-00094.Van Vickle.

PMID:
18317569
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Brain imaging and fluid biomarker analysis in young adults at genetic risk for autosomal dominant Alzheimer's disease in the presenilin 1 E280A kindred: a case-control study.

Reiman EM, Quiroz YT, Fleisher AS, Chen K, Velez-Pardo C, Jimenez-Del-Rio M, Fagan AM, Shah AR, Alvarez S, Arbelaez A, Giraldo M, Acosta-Baena N, Sperling RA, Dickerson B, Stern CE, Tirado V, Munoz C, Reiman RA, Huentelman MJ, Alexander GE, Langbaum JB, Kosik KS, Tariot PN, Lopera F.

Lancet Neurol. 2012 Dec;11(12):1048-56. doi: 10.1016/S1474-4422(12)70228-4. Epub 2012 Nov 6.

PMID:
23137948
[PubMed - indexed for MEDLINE]
17.

Genes and mechanisms involved in beta-amyloid generation and Alzheimer's disease.

Steiner H, Capell A, Leimer U, Haass C.

Eur Arch Psychiatry Clin Neurosci. 1999;249(6):266-70. Review.

PMID:
10653281
[PubMed - indexed for MEDLINE]
18.

γ-Secretase complexes containing caspase-cleaved presenilin-1 increase intracellular Aβ(42) /Aβ(40) ratio.

Hedskog L, Petersen CA, Svensson AI, Welander H, Tjernberg LO, Karlström H, Ankarcrona M.

J Cell Mol Med. 2011 Oct;15(10):2150-63. doi: 10.1111/j.1582-4934.2010.01208.x.

PMID:
21054783
[PubMed - indexed for MEDLINE]
19.

Alzheimer's disease-linked mutations in presenilin-1 result in a drastic loss of activity in purified γ-secretase complexes.

Cacquevel M, Aeschbach L, Houacine J, Fraering PC.

PLoS One. 2012;7(4):e35133. doi: 10.1371/journal.pone.0035133. Epub 2012 Apr 18.

PMID:
22529981
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Alternative processing of γ-secretase substrates in common forms of mild cognitive impairment and Alzheimer's disease: evidence for γ-secretase dysfunction.

Hata S, Fujishige S, Araki Y, Taniguchi M, Urakami K, Peskind E, Akatsu H, Araseki M, Yamamoto K, Martins RN, Maeda M, Nishimura M, Levey A, Chung KA, Montine T, Leverenz J, Fagan A, Goate A, Bateman R, Holtzman DM, Yamamoto T, Nakaya T, Gandy S, Suzuki T.

Ann Neurol. 2011 Jun;69(6):1026-31. doi: 10.1002/ana.22343.

PMID:
21681798
[PubMed - indexed for MEDLINE]
Free PMC Article

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