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Results: 1 to 20 of 131

1.

GRK2: multiple roles beyond G protein-coupled receptor desensitization.

Evron T, Daigle TL, Caron MG.

Trends Pharmacol Sci. 2012 Mar;33(3):154-64. doi: 10.1016/j.tips.2011.12.003. Epub 2012 Jan 23. Review.

PMID:
22277298
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Roles of GRK2 in cell signaling beyond GPCR desensitization: GRK2-HDAC6 interaction modulates cell spreading and motility.

Penela P, Lafarga V, Tapia O, Rivas V, Nogués L, Lucas E, Vila-Bedmar R, Murga C, Mayor F Jr.

Sci Signal. 2012 May 15;5(224):pt3. doi: 10.1126/scisignal.2003098.

PMID:
22589388
[PubMed - indexed for MEDLINE]
3.

Roles of phosphorylation-dependent and -independent mechanisms in the regulation of histamine H2 receptor by G protein-coupled receptor kinase 2.

Fernandez N, Gottardo FL, Alonso MN, Monczor F, Shayo C, Davio C.

J Biol Chem. 2011 Aug 19;286(33):28697-706. doi: 10.1074/jbc.M111.269613. Epub 2011 Jun 24.

PMID:
21705320
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

GRK2-dependent desensitization downstream of G proteins.

Jurado-Pueyo M, Campos PM, Mayor F, Murga C.

J Recept Signal Transduct Res. 2008;28(1-2):59-70. doi: 10.1080/10799890801941939 . Review.

PMID:
18437630
[PubMed - indexed for MEDLINE]
5.

The G protein-coupled receptor kinase (GRK) interactome: role of GRKs in GPCR regulation and signaling.

Ribas C, Penela P, Murga C, Salcedo A, García-Hoz C, Jurado-Pueyo M, Aymerich I, Mayor F Jr.

Biochim Biophys Acta. 2007 Apr;1768(4):913-22. Epub 2006 Sep 30. Review.

PMID:
17084806
[PubMed - indexed for MEDLINE]
Free Article
6.

Endogenous Gs-coupled receptors in smooth muscle exhibit differential susceptibility to GRK2/3-mediated desensitization.

Kong KC, Gandhi U, Martin TJ, Anz CB, Yan H, Misior AM, Pascual RM, Deshpande DA, Penn RB.

Biochemistry. 2008 Sep 2;47(35):9279-88. doi: 10.1021/bi801056w. Epub 2008 Aug 9.

PMID:
18690720
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Smoothened signaling in vertebrates is facilitated by a G protein-coupled receptor kinase.

Philipp M, Fralish GB, Meloni AR, Chen W, MacInnes AW, Barak LS, Caron MG.

Mol Biol Cell. 2008 Dec;19(12):5478-89. doi: 10.1091/mbc.E08-05-0448. Epub 2008 Sep 24.

PMID:
18815277
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Growth Arrest Specific 8 (Gas8) and G protein-coupled receptor kinase 2 (GRK2) cooperate in the control of Smoothened signaling.

Evron T, Philipp M, Lu J, Meloni AR, Burkhalter M, Chen W, Caron MG.

J Biol Chem. 2011 Aug 5;286(31):27676-86. doi: 10.1074/jbc.M111.234666. Epub 2011 Jun 8.

PMID:
21659505
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Phosphorylation of GRK2 by PKA augments GRK2-mediated phosphorylation, internalization, and desensitization of VPAC2 receptors in smooth muscle.

Murthy KS, Mahavadi S, Huang J, Zhou H, Sriwai W.

Am J Physiol Cell Physiol. 2008 Feb;294(2):C477-87. Epub 2007 Dec 12.

PMID:
18077607
[PubMed - indexed for MEDLINE]
Free Article
10.

Selective recruitment of G protein-coupled receptor kinases (GRKs) controls signaling of the insulin-like growth factor 1 receptor.

Zheng H, Worrall C, Shen H, Issad T, Seregard S, Girnita A, Girnita L.

Proc Natl Acad Sci U S A. 2012 May 1;109(18):7055-60. doi: 10.1073/pnas.1118359109. Epub 2012 Apr 16.

PMID:
22509025
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Drosophila G-protein-coupled receptor kinase 2 regulates cAMP-dependent Hedgehog signaling.

Cheng S, Maier D, Hipfner DR.

Development. 2012 Jan;139(1):85-94. doi: 10.1242/dev.068817. Epub 2011 Nov 17.

PMID:
22096079
[PubMed - indexed for MEDLINE]
Free Article
12.
13.

Physiological changes in GRK2 regulate CCL2-induced signaling to ERK1/2 and Akt but not to MEK1/2 and calcium.

Kleibeuker W, Jurado-Pueyo M, Murga C, Eijkelkamp N, Mayor F Jr, Heijnen CJ, Kavelaars A.

J Neurochem. 2008 Feb;104(4):979-92. Epub 2007 Oct 30.

PMID:
17971124
[PubMed - indexed for MEDLINE]
14.

The complex G protein-coupled receptor kinase 2 (GRK2) interactome unveils new physiopathological targets.

Penela P, Murga C, Ribas C, Lafarga V, Mayor F Jr.

Br J Pharmacol. 2010 Jun;160(4):821-32. doi: 10.1111/j.1476-5381.2010.00727.x. Review.

PMID:
20590581
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Regulation of smoothened by Drosophila G-protein-coupled receptor kinases.

Cheng S, Maier D, Neubueser D, Hipfner DR.

Dev Biol. 2010 Jan 1;337(1):99-109. doi: 10.1016/j.ydbio.2009.10.014. Epub 2009 Oct 20.

PMID:
19850026
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

EGF transregulates opioid receptors through EGFR-mediated GRK2 phosphorylation and activation.

Chen Y, Long H, Wu Z, Jiang X, Ma L.

Mol Biol Cell. 2008 Jul;19(7):2973-83. doi: 10.1091/mbc.E07-10-1058. Epub 2008 May 7.

PMID:
18463167
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Synucleins are a novel class of substrates for G protein-coupled receptor kinases.

Pronin AN, Morris AJ, Surguchov A, Benovic JL.

J Biol Chem. 2000 Aug 25;275(34):26515-22.

PMID:
10852916
[PubMed - indexed for MEDLINE]
Free Article
18.

Phosphorylation-independent regulation of metabotropic glutamate receptor 5 desensitization and internalization by G protein-coupled receptor kinase 2 in neurons.

Ribeiro FM, Ferreira LT, Paquet M, Cregan T, Ding Q, Gros R, Ferguson SS.

J Biol Chem. 2009 Aug 28;284(35):23444-53. doi: 10.1074/jbc.M109.000778. Epub 2009 Jun 29.

PMID:
19564331
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Cytoplasmic tail of D1 dopaminergic receptor differentially regulates desensitization and phosphorylation by G protein-coupled receptor kinase 2 and 3.

Sedaghat K, Tiberi M.

Cell Signal. 2011 Jan;23(1):180-92. doi: 10.1016/j.cellsig.2010.09.002. Epub 2010 Sep 17.

PMID:
20837135
[PubMed - indexed for MEDLINE]
20.

Roles of phosphorylation-dependent and -independent mechanisms in the regulation of M1 muscarinic acetylcholine receptors by G protein-coupled receptor kinase 2 in hippocampal neurons.

Willets JM, Nahorski SR, Challiss RA.

J Biol Chem. 2005 May 13;280(19):18950-8. Epub 2005 Mar 2.

PMID:
15743771
[PubMed - indexed for MEDLINE]
Free Article

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