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Items: 1 to 20 of 94


LC-MS/MS characterization of phospholipid content in daptomycin-susceptible and -resistant isolates of Staphylococcus aureus with mutations in mprF.

Rubio A, Moore J, Varoglu M, Conrad M, Chu M, Shaw W, Silverman JA.

Mol Membr Biol. 2012 Feb;29(1):1-8. doi: 10.3109/09687688.2011.640948. Epub 2012 Jan 26.


Causal role of single nucleotide polymorphisms within the mprF gene of Staphylococcus aureus in daptomycin resistance.

Yang SJ, Mishra NN, Rubio A, Bayer AS.

Antimicrob Agents Chemother. 2013 Nov;57(11):5658-64. doi: 10.1128/AAC.01184-13. Epub 2013 Sep 3.


Regulation of mprF in daptomycin-nonsusceptible Staphylococcus aureus strains.

Yang SJ, Xiong YQ, Dunman PM, Schrenzel J, François P, Peschel A, Bayer AS.

Antimicrob Agents Chemother. 2009 Jun;53(6):2636-7. doi: 10.1128/AAC.01415-08. Epub 2009 Mar 16.


Emergence of daptomycin resistance in daptomycin-naïve rabbits with methicillin-resistant Staphylococcus aureus prosthetic joint infection is associated with resistance to host defense cationic peptides and mprF polymorphisms.

Mishra NN, Yang SJ, Chen L, Muller C, Saleh-Mghir A, Kuhn S, Peschel A, Yeaman MR, Nast CC, Kreiswirth BN, Crémieux AC, Bayer AS.

PLoS One. 2013 Aug 19;8(8):e71151. doi: 10.1371/journal.pone.0071151. eCollection 2013.


VraSR two-component regulatory system contributes to mprF-mediated decreased susceptibility to daptomycin in in vivo-selected clinical strains of methicillin-resistant Staphylococcus aureus.

Mehta S, Cuirolo AX, Plata KB, Riosa S, Silverman JA, Rubio A, Rosato RR, Rosato AE.

Antimicrob Agents Chemother. 2012 Jan;56(1):92-102. doi: 10.1128/AAC.00432-10. Epub 2011 Oct 10.


Correlation of cell membrane lipid profiles with daptomycin resistance in methicillin-resistant Staphylococcus aureus.

Mishra NN, Bayer AS.

Antimicrob Agents Chemother. 2013 Feb;57(2):1082-5. doi: 10.1128/AAC.02182-12. Epub 2012 Dec 17.


Heterogeneity of mprF sequences in methicillin-resistant Staphylococcus aureus clinical isolates: role in cross-resistance between daptomycin and host defense antimicrobial peptides.

Bayer AS, Mishra NN, Sakoulas G, Nonejuie P, Nast CC, Pogliano J, Chen KT, Ellison SN, Yeaman MR, Yang SJ.

Antimicrob Agents Chemother. 2014 Dec;58(12):7462-7. doi: 10.1128/AAC.03422-14. Epub 2014 Oct 6.


The lipid-modifying multiple peptide resistance factor is an oligomer consisting of distinct interacting synthase and flippase subunits.

Ernst CM, Kuhn S, Slavetinsky CJ, Krismer B, Heilbronner S, Gekeler C, Kraus D, Wagner S, Peschel A.

MBio. 2015 Jan 27;6(1). pii: e02340-14. doi: 10.1128/mBio.02340-14.


Daptomycin nonsusceptibility in Staphylococcus aureus with reduced vancomycin susceptibility is independent of alterations in MprF.

Pillai SK, Gold HS, Sakoulas G, Wennersten C, Moellering RC Jr, Eliopoulos GM.

Antimicrob Agents Chemother. 2007 Jun;51(6):2223-5. Epub 2007 Apr 2.


Analysis of cell membrane characteristics of in vitro-selected daptomycin-resistant strains of methicillin-resistant Staphylococcus aureus.

Mishra NN, Yang SJ, Sawa A, Rubio A, Nast CC, Yeaman MR, Bayer AS.

Antimicrob Agents Chemother. 2009 Jun;53(6):2312-8. doi: 10.1128/AAC.01682-08. Epub 2009 Mar 30.


Broad-spectrum antimicrobial peptide resistance by MprF-mediated aminoacylation and flipping of phospholipids.

Ernst CM, Peschel A.

Mol Microbiol. 2011 Apr;80(2):290-9. doi: 10.1111/j.1365-2958.2011.07576.x. Epub 2011 Mar 1. Review.


Regulation of mprF by antisense RNA restores daptomycin susceptibility to daptomycin-resistant isolates of Staphylococcus aureus.

Rubio A, Conrad M, Haselbeck RJ, G C K, Brown-Driver V, Finn J, Silverman JA.

Antimicrob Agents Chemother. 2011 Jan;55(1):364-7. doi: 10.1128/AAC.00429-10. Epub 2010 Oct 25.


Impact of daptomycin resistance on Staphylococcus aureus virulence.

Cameron DR, Mortin LI, Rubio A, Mylonakis E, Moellering RC Jr, Eliopoulos GM, Peleg AY.

Virulence. 2015;6(2):127-31. doi: 10.1080/21505594.2015.1011532.


Mechanisms of in-vitro-selected daptomycin-non-susceptibility in Staphylococcus aureus.

Patel D, Husain M, Vidaillac C, Steed ME, Rybak MJ, Seo SM, Kaatz GW.

Int J Antimicrob Agents. 2011 Nov;38(5):442-6. doi: 10.1016/j.ijantimicag.2011.06.010. Epub 2011 Aug 12.


The bacterial defensin resistance protein MprF consists of separable domains for lipid lysinylation and antimicrobial peptide repulsion.

Ernst CM, Staubitz P, Mishra NN, Yang SJ, Hornig G, Kalbacher H, Bayer AS, Kraus D, Peschel A.

PLoS Pathog. 2009 Nov;5(11):e1000660. doi: 10.1371/journal.ppat.1000660. Epub 2009 Nov 13.


Daptomycin: mechanisms of action and resistance, and biosynthetic engineering.

Baltz RH.

Curr Opin Chem Biol. 2009 Apr;13(2):144-51. doi: 10.1016/j.cbpa.2009.02.031. Epub 2009 Mar 19. Review.


Genetic changes that correlate with reduced susceptibility to daptomycin in Staphylococcus aureus.

Friedman L, Alder JD, Silverman JA.

Antimicrob Agents Chemother. 2006 Jun;50(6):2137-45.

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