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A novel approach for the rapid mutagenesis and directed evolution of the structural genes of west nile virus.

Lin TY, Dowd KA, Manhart CJ, Nelson S, Whitehead SS, Pierson TC.

J Virol. 2012 Apr;86(7):3501-12. doi: 10.1128/JVI.06435-11. Epub 2012 Jan 18.


Identification of residues in West Nile virus pre-membrane protein that influence viral particle secretion and virulence.

Setoh YX, Prow NA, Hobson-Peters J, Lobigs M, Young PR, Khromykh AA, Hall RA.

J Gen Virol. 2012 Sep;93(Pt 9):1965-75. doi: 10.1099/vir.0.044453-0. Epub 2012 Jul 4.


Role of BC loop residues in structure, function and antigenicity of the West Nile virus envelope protein receptor-binding domain III.

Zhang S, Bovshik EI, Maillard R, Gromowski GD, Volk DE, Schein CH, Huang CY, Gorenstein DG, Lee JC, Barrett AD, Beasley DW.

Virology. 2010 Jul 20;403(1):85-91. doi: 10.1016/j.virol.2010.03.038. Epub 2010 May 6.


West Nile virus: characterization and diagnostic applications of monoclonal antibodies.

Lelli D, Moreno A, Brocchi E, Sozzi E, Capucci L, Canelli E, Barbieri I, Zeller H, Cordioli P.

Virol J. 2012 Apr 13;9:81. doi: 10.1186/1743-422X-9-81.


Structural gene (prME) chimeras of St Louis encephalitis virus and West Nile virus exhibit altered in vitro cytopathic and growth phenotypes.

Maharaj PD, Anishchenko M, Langevin SA, Fang Y, Reisen WK, Brault AC.

J Gen Virol. 2012 Jan;93(Pt 1):39-49. doi: 10.1099/vir.0.033159-0. Epub 2011 Sep 21.


Envelope and pre-membrane protein structural amino acid mutations mediate diminished avian growth and virulence of a Mexican West Nile virus isolate.

Langevin SA, Bowen RA, Ramey WN, Sanders TA, Maharaj PD, Fang Y, Cornelius J, Barker CM, Reisen WK, Beasley DW, Barrett AD, Kinney RM, Huang CY, Brault AC.

J Gen Virol. 2011 Dec;92(Pt 12):2810-20. doi: 10.1099/vir.0.035535-0. Epub 2011 Aug 24.


The Fc region of an antibody impacts the neutralization of West Nile viruses in different maturation states.

Lee PD, Mukherjee S, Edeling MA, Dowd KA, Austin SK, Manhart CJ, Diamond MS, Fremont DH, Pierson TC.

J Virol. 2013 Dec;87(24):13729-40. doi: 10.1128/JVI.02340-13. Epub 2013 Oct 9.


Tyrosine 78 of premembrane protein is essential for assembly of West Nile virus.

Tan TT, Bhuvanakantham R, Li J, Howe J, Ng ML.

J Gen Virol. 2009 May;90(Pt 5):1081-92. doi: 10.1099/vir.0.007872-0. Epub 2009 Mar 4.


Effects of the number of amino acid residues in the signal segment upstream or downstream of the NS2B-3 cleavage site on production and secretion of prM/M-E virus-like particles of West Nile virus.

Takahashi H, Ohtaki N, Maeda-Sato M, Tanaka M, Tanaka K, Sawa H, Ishikawa T, Takamizawa A, Takasaki T, Hasegawa H, Sata T, Hall WW, Kurata T, Kojima A.

Microbes Infect. 2009 Nov;11(13):1019-28. doi: 10.1016/j.micinf.2009.07.009. Epub 2009 Aug 7.


Diversity and evolution of West Nile virus in Illinois and the United States, 2002-2005.

Bertolotti L, Kitron U, Goldberg TL.

Virology. 2007 Mar 30;360(1):143-9. Epub 2006 Nov 20.


Live measles vaccine expressing the secreted form of the West Nile virus envelope glycoprotein protects against West Nile virus encephalitis.

Desprès P, Combredet C, Frenkiel MP, Lorin C, Brahic M, Tangy F.

J Infect Dis. 2005 Jan 15;191(2):207-14. Epub 2004 Dec 10.


A DNA vaccine encoding the E protein of West Nile virus is protective and can be boosted by recombinant domain DIII.

Schneeweiss A, Chabierski S, Salomo M, Delaroque N, Al-Robaiy S, Grunwald T, Bürki K, Liebert UG, Ulbert S.

Vaccine. 2011 Aug 26;29(37):6352-7. doi: 10.1016/j.vaccine.2011.04.116. Epub 2011 May 17.


Development of a humanized monoclonal antibody with therapeutic potential against West Nile virus.

Oliphant T, Engle M, Nybakken GE, Doane C, Johnson S, Huang L, Gorlatov S, Mehlhop E, Marri A, Chung KM, Ebel GD, Kramer LD, Fremont DH, Diamond MS.

Nat Med. 2005 May;11(5):522-30. Epub 2005 Apr 24.


A glycosylated peptide in the West Nile virus envelope protein is immunogenic during equine infection.

Hobson-Peters J, Toye P, Sánchez MD, Bossart KN, Wang LF, Clark DC, Cheah WY, Hall RA.

J Gen Virol. 2008 Dec;89(Pt 12):3063-72. doi: 10.1099/vir.0.2008/003731-0.


Antibodies against the envelope glycoprotein promote infectivity of immature dengue virus serotype 2.

da Silva Voorham JM, Rodenhuis-Zybert IA, Ayala Nuñez NV, Colpitts TM, van der Ende-Metselaar H, Fikrig E, Diamond MS, Wilschut J, Smit JM.

PLoS One. 2012;7(3):e29957. doi: 10.1371/journal.pone.0029957. Epub 2012 Mar 14.


A West Nile virus recombinant protein vaccine that coactivates innate and adaptive immunity.

McDonald WF, Huleatt JW, Foellmer HG, Hewitt D, Tang J, Desai P, Price A, Jacobs A, Takahashi VN, Huang Y, Nakaar V, Alexopoulou L, Fikrig E, Powell TJ.

J Infect Dis. 2007 Jun 1;195(11):1607-17. Epub 2007 Apr 17.

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