Send to:

Choose Destination

Similar articles for PubMed (Select 22254832)

See comment in PubMed Commons below
Conf Proc IEEE Eng Med Biol Soc. 2011;2011:2430-3. doi: 10.1109/IEMBS.2011.6090676.

An application of monotone functions decomposition to the reconstruction of gene regulatory networks.

Author information

  • 1Dept of Mechanical Engineering, Boston University, Boston, MA 02215, USA.


We describe the reconstruction of a gene regulatory network involved with the Toll-like Receptor signaling pathways. By applying our recent identification algorithm to a time series gene expression dataset, we identify regulatory interactions between genes and construct discrete-time piece-wise affine regulatory functions. Our validation shows that our model predicts the expression levels of the genes involved in the network with good accuracy.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for IEEE Engineering in Medicine and Biology Society
    Loading ...
    Write to the Help Desk