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Conf Proc IEEE Eng Med Biol Soc. 2011;2011:2430-3. doi: 10.1109/IEMBS.2011.6090676.

An application of monotone functions decomposition to the reconstruction of gene regulatory networks.

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  • 1Dept of Mechanical Engineering, Boston University, Boston, MA 02215, USA. rahul.jhu@gmail.com

Abstract

We describe the reconstruction of a gene regulatory network involved with the Toll-like Receptor signaling pathways. By applying our recent identification algorithm to a time series gene expression dataset, we identify regulatory interactions between genes and construct discrete-time piece-wise affine regulatory functions. Our validation shows that our model predicts the expression levels of the genes involved in the network with good accuracy.

PMID:
22254832
[PubMed - indexed for MEDLINE]
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