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Items: 1 to 20 of 208

1.

Expression, purification and preliminary biochemical and structural characterization of the leucine rich repeat namesake domain of leucine rich repeat kinase 2.

Vancraenenbroeck R, Lobbestael E, Weeks SD, Strelkov SV, Baekelandt V, Taymans JM, De Maeyer M.

Biochim Biophys Acta. 2012 Mar;1824(3):450-60. doi: 10.1016/j.bbapap.2011.12.009. Epub 2012 Jan 11.

PMID:
22251894
2.

Conformational heterogeneity of the Roc domains in C. tepidum Roc-COR and implications for human LRRK2 Parkinson mutations.

Rudi K, Ho FY, Gilsbach BK, Pots H, Wittinghofer A, Kortholt A, Klare JP.

Biosci Rep. 2015 Aug 26;35(5). pii: e00254. doi: 10.1042/BSR20150128.

3.

Analysis of LRRK2 accessory repeat domains: prediction of repeat length, number and sites of Parkinson's disease mutations.

Mills RD, Mulhern TD, Cheng HC, Culvenor JG.

Biochem Soc Trans. 2012 Oct;40(5):1086-9. Review.

PMID:
22988870
4.

Expression, purification and preliminary biochemical studies of the N-terminal domain of leucine-rich repeat kinase 2.

Lu B, Zhai Y, Wu C, Pang X, Xu Z, Sun F.

Biochim Biophys Acta. 2010 Sep;1804(9):1780-4. doi: 10.1016/j.bbapap.2010.05.004. Epub 2010 May 20.

PMID:
20493972
5.

The Parkinson disease gene LRRK2: evolutionary and structural insights.

Marín I.

Mol Biol Evol. 2006 Dec;23(12):2423-33. Epub 2006 Sep 11.

6.
7.

Mutations in the LRRK2 Roc-COR tandem domain link Parkinson's disease to Wnt signalling pathways.

Sancho RM, Law BM, Harvey K.

Hum Mol Genet. 2009 Oct 15;18(20):3955-68. doi: 10.1093/hmg/ddp337. Epub 2009 Jul 22.

8.

Leucine-rich repeat kinase 2: relevance to Parkinson's disease.

Guo L, Wang W, Chen SG.

Int J Biochem Cell Biol. 2006;38(9):1469-75. Epub 2006 Mar 2. Review.

PMID:
16600664
9.

Prediction of the repeat domain structures and impact of parkinsonism-associated variations on structure and function of all functional domains of leucine-rich repeat kinase 2 (LRRK2).

Mills RD, Mulhern TD, Liu F, Culvenor JG, Cheng HC.

Hum Mutat. 2014 Apr;35(4):395-412. doi: 10.1002/humu.22515. Epub 2014 Feb 24. Review.

PMID:
24470158
10.

Identification of the autophosphorylation sites of LRRK2.

Kamikawaji S, Ito G, Iwatsubo T.

Biochemistry. 2009 Nov 24;48(46):10963-75. doi: 10.1021/bi9011379.

PMID:
19824698
11.

Phosphopeptide analysis reveals two discrete clusters of phosphorylation in the N-terminus and the Roc domain of the Parkinson-disease associated protein kinase LRRK2.

Gloeckner CJ, Boldt K, von Zweydorf F, Helm S, Wiesent L, Sarioglu H, Ueffing M.

J Proteome Res. 2010 Apr 5;9(4):1738-45. doi: 10.1021/pr9008578.

PMID:
20108944
12.

LRRK2 in Parkinson's disease: biochemical functions.

Anand VS, Braithwaite SP.

FEBS J. 2009 Nov;276(22):6428-35. doi: 10.1111/j.1742-4658.2009.07341.x. Epub 2009 Oct 5. Review.

13.

Human leucine-rich repeat kinase 1 and 2: intersecting or unrelated functions?

Civiero L, Bubacco L.

Biochem Soc Trans. 2012 Oct;40(5):1095-101. Review.

PMID:
22988872
14.

Dependence of leucine-rich repeat kinase 2 (LRRK2) kinase activity on dimerization.

Sen S, Webber PJ, West AB.

J Biol Chem. 2009 Dec 25;284(52):36346-56. doi: 10.1074/jbc.M109.025437. Epub 2009 Oct 13.

15.

Contribution of GTPase activity to LRRK2-associated Parkinson disease.

Tsika E, Moore DJ.

Small GTPases. 2013 Jul-Sep;4(3):164-70. doi: 10.4161/sgtp.25130. Epub 2013 Jun 10. Review.

16.

LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity.

Jaleel M, Nichols RJ, Deak M, Campbell DG, Gillardon F, Knebel A, Alessi DR.

Biochem J. 2007 Jul 15;405(2):307-17.

17.

A direct interaction between leucine-rich repeat kinase 2 and specific β-tubulin isoforms regulates tubulin acetylation.

Law BM, Spain VA, Leinster VH, Chia R, Beilina A, Cho HJ, Taymans JM, Urban MK, Sancho RM, Blanca Ramírez M, Biskup S, Baekelandt V, Cai H, Cookson MR, Berwick DC, Harvey K.

J Biol Chem. 2014 Jan 10;289(2):895-908. doi: 10.1074/jbc.M113.507913. Epub 2013 Nov 25.

18.

The GTPase function of LRRK2.

Taymans JM.

Biochem Soc Trans. 2012 Oct;40(5):1063-9. Review.

PMID:
22988866
19.

In vitro characterization of the cysteine-rich capping domains in a plant leucine rich repeat protein.

Kolade OO, Bamford VA, Ancillo Anton G, Jones JD, Vera P, Hemmings AM.

Biochim Biophys Acta. 2006 Jun;1764(6):1043-53. Epub 2006 Apr 4.

PMID:
16713408
20.

Leucine-rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson's disease R1441C/G mutants.

Li X, Tan YC, Poulose S, Olanow CW, Huang XY, Yue Z.

J Neurochem. 2007 Oct;103(1):238-47. Epub 2007 Jul 10.

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