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Results: 1 to 20 of 152

1.

Inhibition of P-glycoprotein enhances transport of imipramine across the blood-brain barrier: microdialysis studies in conscious freely moving rats.

O'Brien FE, Clarke G, Fitzgerald P, Dinan TG, Griffin BT, Cryan JF.

Br J Pharmacol. 2012 Jun;166(4):1333-43. doi: 10.1111/j.1476-5381.2012.01858.x.

PMID:
22250926
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Verapamil in treatment resistant depression: a role for the P-glycoprotein transporter?

Clarke G, O'Mahony SM, Cryan JF, Dinan TG.

Hum Psychopharmacol. 2009 Apr;24(3):217-23. doi: 10.1002/hup.1008.

PMID:
19212940
[PubMed - indexed for MEDLINE]
3.

P-glycoprotein inhibition increases the brain distribution and antidepressant-like activity of escitalopram in rodents.

O'Brien FE, O'Connor RM, Clarke G, Dinan TG, Griffin BT, Cryan JF.

Neuropsychopharmacology. 2013 Oct;38(11):2209-19. doi: 10.1038/npp.2013.120. Epub 2013 May 14.

PMID:
23670590
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Duration and degree of cyclosporin induced P-glycoprotein inhibition in the rat blood-brain barrier can be studied with PET.

Syvänen S, Blomquist G, Sprycha M, Höglund AU, Roman M, Eriksson O, Hammarlund-Udenaes M, Långström B, Bergström M.

Neuroimage. 2006 Sep;32(3):1134-41. Epub 2006 Jul 20.

PMID:
16857389
[PubMed - indexed for MEDLINE]
5.

Verapamil P-glycoprotein transport across the rat blood-brain barrier: cyclosporine, a concentration inhibition analysis, and comparison with human data.

Hsiao P, Sasongko L, Link JM, Mankoff DA, Muzi M, Collier AC, Unadkat JD.

J Pharmacol Exp Ther. 2006 May;317(2):704-10. Epub 2006 Jan 13.

PMID:
16415090
[PubMed - indexed for MEDLINE]
Free Article
6.

Influence of P-glycoprotein inhibition on the distribution of the tricyclic antidepressant nortriptyline over the blood-brain barrier.

Ejsing TB, Linnet K.

Hum Psychopharmacol. 2005 Mar;20(2):149-53.

PMID:
15624117
[PubMed - indexed for MEDLINE]
7.

In vitro-to-in vivo prediction of P-glycoprotein-based drug interactions at the human and rodent blood-brain barrier.

Hsiao P, Bui T, Ho RJ, Unadkat JD.

Drug Metab Dispos. 2008 Mar;36(3):481-4. Epub 2007 Dec 5.

PMID:
18057117
[PubMed - indexed for MEDLINE]
Free Article
8.

Imaging of cyclosporine inhibition of P-glycoprotein activity using 11C-verapamil in the brain: studies of healthy humans.

Muzi M, Mankoff DA, Link JM, Shoner S, Collier AC, Sasongko L, Unadkat JD.

J Nucl Med. 2009 Aug;50(8):1267-75. doi: 10.2967/jnumed.108.059162. Epub 2009 Jul 17.

PMID:
19617341
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

The P-glycoprotein inhibitor cyclosporin A differentially influences behavioural and neurochemical responses to the antidepressant escitalopram.

O'Brien FE, O'Connor RM, Clarke G, Donovan MD, Dinan TG, Griffin BT, Cryan JF.

Behav Brain Res. 2014 Mar 15;261:17-25. doi: 10.1016/j.bbr.2013.11.027. Epub 2013 Nov 23.

PMID:
24280122
[PubMed - indexed for MEDLINE]
10.

Imipramine distribution among red blood cells, plasma and brain tissue.

Fisar Z, Krulik R, Fuksová K, Sikora J.

Gen Physiol Biophys. 1996 Feb;15(1):51-64.

PMID:
8902557
[PubMed - indexed for MEDLINE]
11.

Dose-response assessment of tariquidar and elacridar and regional quantification of P-glycoprotein inhibition at the rat blood-brain barrier using (R)-[(11)C]verapamil PET.

Kuntner C, Bankstahl JP, Bankstahl M, Stanek J, Wanek T, Stundner G, Karch R, Brauner R, Meier M, Ding X, Müller M, Löscher W, Langer O.

Eur J Nucl Med Mol Imaging. 2010 May;37(5):942-53. doi: 10.1007/s00259-009-1332-5. Epub 2009 Dec 17.

PMID:
20016890
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

The role of P-glycoprotein in intestinal transport versus the BBB transport of tetraphenylphosphonium.

Swed A, Eyal S, Madar I, Zohar-Kontante H, Weiss L, Hoffman A.

Mol Pharm. 2009 Nov-Dec;6(6):1883-90. doi: 10.1021/mp900170y.

PMID:
19722701
[PubMed - indexed for MEDLINE]
13.

Effect of the p-glycoprotein inhibitor, cyclosporin A, on the distribution of rhodamine-123 to the brain: an in vivo microdialysis study in freely moving rats.

Wang Q, Yang H, Miller DW, Elmquist WF.

Biochem Biophys Res Commun. 1995 Jun 26;211(3):719-26.

PMID:
7598699
[PubMed - indexed for MEDLINE]
14.

Imaging P-glycoprotein transport activity at the human blood-brain barrier with positron emission tomography.

Sasongko L, Link JM, Muzi M, Mankoff DA, Yang X, Collier AC, Shoner SC, Unadkat JD.

Clin Pharmacol Ther. 2005 Jun;77(6):503-14.

PMID:
15961982
[PubMed - indexed for MEDLINE]
15.

The influence of P-glycoprotein on cerebral and hepatic concentrations of nortriptyline and its metabolites.

Ejsing TB, Hasselstrøm J, Linnet K.

Drug Metabol Drug Interact. 2006;21(3-4):139-62.

PMID:
16841511
[PubMed - indexed for MEDLINE]
16.

Modeling cyclosporine A inhibition of the distribution of a P-glycoprotein PET ligand, 11C-verapamil, into the maternal brain and fetal liver of the pregnant nonhuman primate: impact of tissue blood flow and site of inhibition.

Ke AB, Eyal S, Chung FS, Link JM, Mankoff DA, Muzi M, Unadkat JD.

J Nucl Med. 2013 Mar;54(3):437-46. doi: 10.2967/jnumed.112.111732. Epub 2013 Jan 28.

PMID:
23359659
[PubMed - indexed for MEDLINE]
Free Article
17.

A new in vivo method to study P-glycoprotein transport in tumors and the blood-brain barrier.

Hendrikse NH, de Vries EG, Eriks-Fluks L, van der Graaf WT, Hospers GA, Willemsen AT, Vaalburg W, Franssen EJ.

Cancer Res. 1999 May 15;59(10):2411-6.

PMID:
10344751
[PubMed - indexed for MEDLINE]
Free Article
18.

P glycoprotein regulated transport of glutamate at blood brain barrier.

Liu XD, Liu GQ.

Acta Pharmacol Sin. 2001 Feb;22(2):111-6.

PMID:
11741514
[PubMed - indexed for MEDLINE]
Free Article
19.

In vivo induction of P-glycoprotein expression at the mouse blood-brain barrier: an intracerebral microdialysis study.

Chan GN, Saldivia V, Yang Y, Pang H, de Lannoy I, Bendayan R.

J Neurochem. 2013 Nov;127(3):342-52. doi: 10.1111/jnc.12344. Epub 2013 Jul 15.

PMID:
23777437
[PubMed - indexed for MEDLINE]
20.

Influence of imipramine on the hypothalamic/pituitary/thyroid axis of the rat.

Kennedy JA, Jarrett DB, Wellby ML.

Metabolism. 1997 Dec;46(12):1429-34.

PMID:
9439538
[PubMed - indexed for MEDLINE]
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