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Results: 1 to 20 of 132

1.

Benzoxaborole antimalarial agents. Part 2: Discovery of fluoro-substituted 7-(2-carboxyethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles.

Zhang YK, Plattner JJ, Freund YR, Easom EE, Zhou Y, Ye L, Zhou H, Waterson D, Gamo FJ, Sanz LM, Ge M, Li Z, Li L, Wang H, Cui H.

Bioorg Med Chem Lett. 2012 Feb 1;22(3):1299-307. doi: 10.1016/j.bmcl.2011.12.096. Epub 2011 Dec 28.

PMID:
22243961
[PubMed - indexed for MEDLINE]
2.

Synthesis and structure-activity relationships of novel benzoxaboroles as a new class of antimalarial agents.

Zhang YK, Plattner JJ, Freund YR, Easom EE, Zhou Y, Gut J, Rosenthal PJ, Waterson D, Gamo FJ, Angulo-Barturen I, Ge M, Li Z, Li L, Jian Y, Cui H, Wang H, Yang J.

Bioorg Med Chem Lett. 2011 Jan 15;21(2):644-51. doi: 10.1016/j.bmcl.2010.12.034. Epub 2010 Dec 10.

PMID:
21195617
[PubMed - indexed for MEDLINE]
3.

Discovery of a new boron-containing antifungal agent, 5-fluoro-1,3-dihydro-1-hydroxy-2,1- benzoxaborole (AN2690), for the potential treatment of onychomycosis.

Baker SJ, Zhang YK, Akama T, Lau A, Zhou H, Hernandez V, Mao W, Alley MR, Sanders V, Plattner JJ.

J Med Chem. 2006 Jul 27;49(15):4447-50.

PMID:
16854048
[PubMed - indexed for MEDLINE]
4.

Antimalarial activity of yingzhaosu A analogues.

Kim HS, Begum K, Ogura N, Wataya Y, Tokuyasu T, Masuyama A, Nojima M, McCullough KJ.

J Med Chem. 2002 Oct 10;45(21):4732-6.

PMID:
12361400
[PubMed - indexed for MEDLINE]
5.

Synthesis of ethyl 5-phenyl-6-oxa-1-azabicyclo[3.1.0]hexane-2-carboxylate derivatives and evaluation of their antimalarial activities.

Ningsanont N, Black DS, Chanphen R, Thebtaranonth Y.

J Med Chem. 2003 Jun 5;46(12):2397-403.

PMID:
12773043
[PubMed - indexed for MEDLINE]
6.

Orally active antimalarial 3-substituted trioxanes: new synthetic methodology and biological evaluation.

Posner GH, Cumming JN, Woo SH, Ploypradith P, Xie S, Shapiro TA.

J Med Chem. 1998 Mar 12;41(6):940-51.

PMID:
9526568
[PubMed - indexed for MEDLINE]
7.

Exploiting a basic chemosensitizing pharmacophore hypothesis. Part 1: synthesis and biological evaluation of novel arylbromide and bicyclic chemosensitizers against drug-resistant malaria parasites.

Chouteau F, Ramanitrahasimbola D, Rasoanaivo P, Chibale K.

Bioorg Med Chem Lett. 2005 Jun 15;15(12):3024-8.

PMID:
15908208
[PubMed - indexed for MEDLINE]
8.

Facile synthesis and in-vitro antimalarial activity of novel α-hydroxy hydrazonates.

Khankischpur M, Hansen FK, Meurer R, Mauz T, Bergmann B, Walter RD, Geffken D.

Arch Pharm (Weinheim). 2011 Nov;344(11):755-64. doi: 10.1002/ardp.201000346. Epub 2011 Sep 20.

PMID:
21932256
[PubMed - indexed for MEDLINE]
9.

Influence of the substituents on the structure and properties of benzoxaboroles.

Adamczyk-Woźniak A, Cyrański MK, Jakubczyk M, Klimentowska P, Koll A, Kołodziejczak J, Pojmaj G, Zubrowska A, Zukowska GZ, Sporzyński A.

J Phys Chem A. 2010 Feb 18;114(6):2324-30. doi: 10.1021/jp9086283.

PMID:
20092259
[PubMed - indexed for MEDLINE]
10.

Synthesis and antimalarial activity of substituted pyrazole derivatives.

Domínguez JN, Charris JE, Caparelli M, Riggione F.

Arzneimittelforschung. 2002;52(6):482-8.

PMID:
12109050
[PubMed - indexed for MEDLINE]
11.

Antimalarial activity of novel 1,2,5,6-tetraoxacycloalkanes and 1,2,5-trioxacycloalkanes.

Kim HS, Begum K, Ogura N, Wataya Y, Nonami Y, Ito T, Masuyama A, Nojima M, McCullough KJ.

J Med Chem. 2003 May 8;46(10):1957-61.

PMID:
12723958
[PubMed - indexed for MEDLINE]
12.

Synthesis, antimalarial activity and cytotoxicity of substituted 3,6-diphenyl-[1,2,4,5]tetraoxanes.

Kumar N, Khan SI, Beena, Rajalakshmi G, Kumaradhas P, Rawat DS.

Bioorg Med Chem. 2009 Aug 1;17(15):5632-8. doi: 10.1016/j.bmc.2009.06.020. Epub 2009 Jun 16.

PMID:
19574054
[PubMed - indexed for MEDLINE]
13.

Reinvestigation of structure-activity relationship of methoxylated chalcones as antimalarials: synthesis and evaluation of 2,4,5-trimethoxy substituted patterns as lead candidates derived from abundantly available natural β-asarone.

Kumar R, Mohanakrishnan D, Sharma A, Kaushik NK, Kalia K, Sinha AK, Sahal D.

Eur J Med Chem. 2010 Nov;45(11):5292-301. doi: 10.1016/j.ejmech.2010.08.049. Epub 2010 Sep 22.

PMID:
20863599
[PubMed - indexed for MEDLINE]
14.

Synthesis and antimalarial activity of dihydroperoxides and tetraoxanes conjugated with bis(benzyl)acetone derivatives.

Franco LL, de Almeida MV, E Silva LF, Vieira PP, Pohlit AM, Valle MS.

Chem Biol Drug Des. 2012 May;79(5):790-7. doi: 10.1111/j.1747-0285.2012.01345.x. Epub 2012 Mar 16.

PMID:
22284812
[PubMed - indexed for MEDLINE]
15.

Synthesis of new 7-chloroquinolinyl thioureas and their biological investigation as potential antimalarial and anticancer agents.

Mahajan A, Yeh S, Nell M, van Rensburg CE, Chibale K.

Bioorg Med Chem Lett. 2007 Oct 15;17(20):5683-5. Epub 2007 Aug 19.

PMID:
17768052
[PubMed - indexed for MEDLINE]
16.

Discovery and structure-activity study of a novel benzoxaborole anti-inflammatory agent (AN2728) for the potential topical treatment of psoriasis and atopic dermatitis.

Akama T, Baker SJ, Zhang YK, Hernandez V, Zhou H, Sanders V, Freund Y, Kimura R, Maples KR, Plattner JJ.

Bioorg Med Chem Lett. 2009 Apr 15;19(8):2129-32. doi: 10.1016/j.bmcl.2009.03.007. Epub 2009 Mar 9.

PMID:
19303290
[PubMed - indexed for MEDLINE]
17.

Synthesis, antimalarial activity and cytotoxic potential of new monocarbonyl analogues of curcumin.

Manohar S, Khan SI, Kandi SK, Raj K, Sun G, Yang X, Calderon Molina AD, Ni N, Wang B, Rawat DS.

Bioorg Med Chem Lett. 2013 Jan 1;23(1):112-6. doi: 10.1016/j.bmcl.2012.11.004. Epub 2012 Nov 10.

PMID:
23218718
[PubMed - indexed for MEDLINE]
18.

Antimalarial simplified 3-aryltrioxanes: synthesis and preclinical efficacy/toxicity testing in rodents.

Posner GH, Jeon HB, Parker MH, Krasavin M, Paik IH, Shapiro TA.

J Med Chem. 2001 Sep 13;44(19):3054-8.

PMID:
11543673
[PubMed - indexed for MEDLINE]
19.

Antiplasmodial and antitumor activity of dihydroartemisinin analogs derived via the aza-Michael addition reaction.

Feng TS, Guantai EM, Nell MJ, van Rensburg CE, Hoppe HC, Chibale K.

Bioorg Med Chem Lett. 2011 May 15;21(10):2882-6. doi: 10.1016/j.bmcl.2011.03.090. Epub 2011 Mar 30.

PMID:
21489789
[PubMed - indexed for MEDLINE]
20.

A short synthesis and biological evaluation of potent and nontoxic antimalarial bridged bicyclic beta-sulfonyl-endoperoxides.

Bachi MD, Korshin EE, Hoos R, Szpilman AM, Ploypradith P, Xie S, Shapiro TA, Posner GH.

J Med Chem. 2003 Jun 5;46(12):2516-33.

PMID:
12773055
[PubMed - indexed for MEDLINE]

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