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Items: 1 to 20 of 150

1.

PPAR-γ activation restores pancreatic islet SERCA2 levels and prevents β-cell dysfunction under conditions of hyperglycemic and cytokine stress.

Kono T, Ahn G, Moss DR, Gann L, Zarain-Herzberg A, Nishiki Y, Fueger PT, Ogihara T, Evans-Molina C.

Mol Endocrinol. 2012 Feb;26(2):257-71. doi: 10.1210/me.2011-1181. Epub 2012 Jan 12.

2.

Pancreatic and duodenal homeobox protein 1 (Pdx-1) maintains endoplasmic reticulum calcium levels through transcriptional regulation of sarco-endoplasmic reticulum calcium ATPase 2b (SERCA2b) in the islet β cell.

Johnson JS, Kono T, Tong X, Yamamoto WR, Zarain-Herzberg A, Merrins MJ, Satin LS, Gilon P, Evans-Molina C.

J Biol Chem. 2014 Nov 21;289(47):32798-810. doi: 10.1074/jbc.M114.575191. Epub 2014 Sep 30.

3.

Peroxisome proliferator-activated receptor gamma activation restores islet function in diabetic mice through reduction of endoplasmic reticulum stress and maintenance of euchromatin structure.

Evans-Molina C, Robbins RD, Kono T, Tersey SA, Vestermark GL, Nunemaker CS, Garmey JC, Deering TG, Keller SR, Maier B, Mirmira RG.

Mol Cell Biol. 2009 Apr;29(8):2053-67. doi: 10.1128/MCB.01179-08. Epub 2009 Feb 23.

4.
5.

Pioglitazone improves insulin secretory capacity and prevents the loss of beta-cell mass in obese diabetic db/db mice: Possible protection of beta cells from oxidative stress.

Ishida H, Takizawa M, Ozawa S, Nakamichi Y, Yamaguchi S, Katsuta H, Tanaka T, Maruyama M, Katahira H, Yoshimoto K, Itagaki E, Nagamatsu S.

Metabolism. 2004 Apr;53(4):488-94.

PMID:
15045697
6.

PPAR-γ activation increases insulin secretion through the up-regulation of the free fatty acid receptor GPR40 in pancreatic β-cells.

Kim HS, Hwang YC, Koo SH, Park KS, Lee MS, Kim KW, Lee MK.

PLoS One. 2013;8(1):e50128. doi: 10.1371/journal.pone.0050128. Epub 2013 Jan 23.

7.

Gene expression regulated by pioglitazone and exenatide in normal and diabetic rat islets exposed to lipotoxicity.

Ghanaat-Pour H, Sjöholm A.

Diabetes Metab Res Rev. 2009 Feb;25(2):163-84. doi: 10.1002/dmrr.896.

PMID:
19065603
8.

Pioglitazone reduces islet triglyceride content and restores impaired glucose-stimulated insulin secretion in heterozygous peroxisome proliferator-activated receptor-gamma-deficient mice on a high-fat diet.

Matsui J, Terauchi Y, Kubota N, Takamoto I, Eto K, Yamashita T, Komeda K, Yamauchi T, Kamon J, Kita S, Noda M, Kadowaki T.

Diabetes. 2004 Nov;53(11):2844-54.

9.

Activation of peroxisome proliferator-activated receptor-gamma protects pancreatic beta-cells from cytokine-induced cytotoxicity via NF kappaB pathway.

Kim EK, Kwon KB, Koo BS, Han MJ, Song MY, Song EK, Han MK, Park JW, Ryu DG, Park BH.

Int J Biochem Cell Biol. 2007;39(6):1260-75. Epub 2007 Apr 19.

PMID:
17521952
10.
11.

Inhibition of human insulin gene transcription by peroxisome proliferator-activated receptor gamma and thiazolidinedione oral antidiabetic drugs.

Schinner S, Krätzner R, Baun D, Dickel C, Blume R, Oetjen E.

Br J Pharmacol. 2009 Jul;157(5):736-45. doi: 10.1111/j.1476-5381.2009.00208.x. Epub 2009 Mar 26.

12.

Molecular mechanism by which pioglitazone preserves pancreatic beta-cells in obese diabetic mice: evidence for acute and chronic actions as a PPARgamma agonist.

Kanda Y, Shimoda M, Hamamoto S, Tawaramoto K, Kawasaki F, Hashiramoto M, Nakashima K, Matsuki M, Kaku K.

Am J Physiol Endocrinol Metab. 2010 Feb;298(2):E278-86. doi: 10.1152/ajpendo.00388.2009. Epub 2009 Nov 17.

13.

Evidence that low-grade systemic inflammation can induce islet dysfunction as measured by impaired calcium handling.

Dula SB, Jecmenica M, Wu R, Jahanshahi P, Verrilli GM, Carter JD, Brayman KL, Nunemaker CS.

Cell Calcium. 2010 Aug-Sep;48(2-3):133-42. doi: 10.1016/j.ceca.2010.07.007. Epub 2010 Aug 25.

14.

[Glitazones protects beta cell function from cytotoxic cytokines through PPAR gamma-dependent mechanisms].

Li X, Wang AP, Yan X, Huang G, Liu BL, Zhou ZG.

Nan Fang Yi Ke Da Xue Xue Bao. 2010 Jul;30(7):1530-3. Chinese.

15.

Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells.

Cardozo AK, Ortis F, Storling J, Feng YM, Rasschaert J, Tonnesen M, Van Eylen F, Mandrup-Poulsen T, Herchuelz A, Eizirik DL.

Diabetes. 2005 Feb;54(2):452-61.

17.

High expression of sarcoplasmic/endoplasmic reticulum Ca(2+)-ATPase 2b blocks cell differentiation in human liposarcoma cells.

Wang L, Li W, Yang Y, Hu Y, Gu Y, Shu Y, Sun Y, Wu X, Shen Y, Xu Q.

Life Sci. 2014 Mar 18;99(1-2):37-43. doi: 10.1016/j.lfs.2014.01.067. Epub 2014 Feb 7.

PMID:
24508653
18.

Mechanisms of control of the free Ca2+ concentration in the endoplasmic reticulum of mouse pancreatic β-cells: interplay with cell metabolism and [Ca2+]c and role of SERCA2b and SERCA3.

Ravier MA, Daro D, Roma LP, Jonas JC, Cheng-Xue R, Schuit FC, Gilon P.

Diabetes. 2011 Oct;60(10):2533-45. doi: 10.2337/db10-1543. Epub 2011 Sep 1.

19.

Alterations of the Ca²⁺ signaling pathway in pancreatic beta-cells isolated from db/db mice.

Liang K, Du W, Lu J, Li F, Yang L, Xue Y, Hille B, Chen L.

Protein Cell. 2014 Oct;5(10):783-94. doi: 10.1007/s13238-014-0075-7. Epub 2014 Jul 24.

20.

Thiazolidinediones protect mouse pancreatic β-cells directly from cytokine-induced cytotoxicity through PPARγ-dependent mechanisms.

Wang AP, Li X, Zheng Y, Liu BL, Huang G, Yan X, Liu Z, Zhou Z.

Acta Diabetol. 2013 Apr;50(2):163-73. doi: 10.1007/s00592-010-0239-8. Epub 2010 Dec 10.

PMID:
21153483
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