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Items: 1 to 20 of 110

1.

Mutational biosynthesis of ansamitocin antibiotics: a diversity-oriented approach to exploit biosynthetic flexibility.

Knobloch T, Harmrolfs K, Taft F, Thomaszewski B, Sasse F, Kirschning A.

Chembiochem. 2011 Mar 7;12(4):540-7. doi: 10.1002/cbic.201000608. Epub 2011 Jan 27.

PMID:
22238146
2.

Determination of the cryptic stereochemistry of the first PKS chain-extension step in ansamitocin biosynthesis by Actinosynnema pretiosum.

Kubota T, Brünjes M, Frenzel T, Xu J, Kirschning A, Floss HG.

Chembiochem. 2006 Aug;7(8):1221-5.

PMID:
16927319
3.

The post-polyketide synthase modification steps in the biosynthesis of the antitumor agent ansamitocin by Actinosynnema pretiosum.

Spiteller P, Bai L, Shang G, Carroll BJ, Yu TW, Floss HG.

J Am Chem Soc. 2003 Nov 26;125(47):14236-7.

PMID:
14624546
4.

Dual carbamoylations on the polyketide and glycosyl moiety by asm21 result in extended ansamitocin biosynthesis.

Li Y, Zhao P, Kang Q, Ma J, Bai L, Deng Z.

Chem Biol. 2011 Dec 23;18(12):1571-80. doi: 10.1016/j.chembiol.2011.11.007.

5.

Timing of the Delta(10,12)-Delta(11,13) double bond migration during ansamitocin biosynthesis in Actinosynnema pretiosum.

Taft F, Brünjes M, Knobloch T, Floss HG, Kirschning A.

J Am Chem Soc. 2009 Mar 25;131(11):3812-3. doi: 10.1021/ja8088923.

PMID:
19292483
6.

Asm8, a specific LAL-type activator of 3-amino-5-hydroxybenzoate biosynthesis in ansamitocin production.

Pan W, Kang Q, Wang L, Bai L, Deng Z.

Sci China Life Sci. 2013 Jul;56(7):601-8. doi: 10.1007/s11427-013-4502-4. Epub 2013 Jul 6.

PMID:
23832249
7.

Chemoenzymatic approaches toward dechloroansamitocin P-3.

Meyer A, Brünjes M, Taft F, Frenzel T, Sasse F, Kirschning A.

Org Lett. 2007 Apr 12;9(8):1489-92. Epub 2007 Mar 23.

PMID:
17378571
8.

The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from Actinosynnema pretiosum.

Yu TW, Bai L, Clade D, Hoffmann D, Toelzer S, Trinh KQ, Xu J, Moss SJ, Leistner E, Floss HG.

Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):7968-73.

9.

Highly active ansamitocin derivatives: mutasynthesis using an AHBA-blocked mutant.

Taft F, Brünjes M, Floss HG, Czempinski N, Grond S, Sasse F, Kirschning A.

Chembiochem. 2008 May 5;9(7):1057-60. doi: 10.1002/cbic.200700742. No abstract available.

PMID:
18381586
10.

N-methylation of the amide bond by methyltransferase asm10 in ansamitocin biosynthesis.

Wu Y, Kang Q, Shang G, Spiteller P, Carroll B, Yu TW, Su W, Bai L, Floss HG.

Chembiochem. 2011 Jul 25;12(11):1759-66. doi: 10.1002/cbic.201100062. Epub 2011 Jun 16.

11.

The ansacarbamitocins: polar ansamitocin derivatives.

Snipes CE, Duebelbeis DO, Olson M, Hahn DR, Dent WH 3rd, Gilbert JR, Werk TL, Davis GE, Lee-Lu R, Graupner PR.

J Nat Prod. 2007 Oct;70(10):1578-81. Epub 2007 Sep 25.

PMID:
17892263
12.

Engineered biosynthesis of an ansamycin polyketide precursor in Escherichia coli.

Watanabe K, Rude MA, Walsh CT, Khosla C.

Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9774-8. Epub 2003 Jul 29.

13.

A new antitumour ansamitocin from Actinosynnema pretiosum.

Wei GZ, Bai LQ, Yang T, Ma J, Zeng Y, Shen YM, Zhao PJ.

Nat Prod Res. 2010 Jul;24(12):1146-50. doi: 10.1080/14786410902916552.

PMID:
20582809
14.

Amide N-glycosylation by Asm25, an N-glycosyltransferase of ansamitocins.

Zhao P, Bai L, Ma J, Zeng Y, Li L, Zhang Y, Lu C, Dai H, Wu Z, Li Y, Wu X, Chen G, Hao X, Shen Y, Deng Z, Floss HG.

Chem Biol. 2008 Aug 25;15(8):863-74. doi: 10.1016/j.chembiol.2008.06.007.

15.

Two novel ansamitocin analogs from Actinosynnema pretiosum.

Siyu-Mao, Hong-Chen, Li-Chen, Chuanxi-Wang, Wei-Jia, Xiaoming-Chen, Huangjian-Yang, Wei-Huang, Wei-Zheng.

Nat Prod Res. 2013;27(17):1532-6. doi: 10.1080/14786419.2012.733388. Epub 2012 Oct 15.

PMID:
23061718
16.

Enhancement of ansamitocin P-3 production in Actinosynnema pretiosum by a synergistic effect of glycerol and glucose.

Gao Y, Fan Y, Nambou K, Wei L, Liu Z, Imanaka T, Hua Q.

J Ind Microbiol Biotechnol. 2014 Jan;41(1):143-52. doi: 10.1007/s10295-013-1374-3. Epub 2013 Oct 31.

PMID:
24174216
17.

Cyclization of synthetic seco-proansamitocins to ansamitocin macrolactams by Actinosynnema pretiosum as biocatalyst.

Harmrolfs K, Brünjes M, Dräger G, Floss HG, Sasse F, Taft F, Kirschning A.

Chembiochem. 2010 Dec 10;11(18):2517-20. doi: 10.1002/cbic.201000422. No abstract available.

18.

New amide N-glycosides of ansamitocins identified from Actinosynnema pretiosum.

Ma J, Zhao PJ, Shen YM.

Arch Pharm Res. 2007 Jun;30(6):670-3.

PMID:
17679541
19.
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