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XRCC4's interaction with XLF is required for coding (but not signal) end joining.

Roy S, Andres SN, Vergnes A, Neal JA, Xu Y, Yu Y, Lees-Miller SP, Junop M, Modesti M, Meek K.

Nucleic Acids Res. 2012 Feb;40(4):1684-94. doi: 10.1093/nar/gkr1315. Epub 2012 Jan 6.


XRCC4/XLF interaction is variably required for DNA repair, and is not required for Ligase IV stimulation.

Roy S, de Melo AJ, Xu Y, Tadi SK, NĂ©grel A, Hendrickson E, Modesti M, Meek K.

Mol Cell Biol. 2015 Jun 22. pii: MCB.01503-14. [Epub ahead of print]


TDP1 promotes assembly of non-homologous end joining protein complexes on DNA.

Heo J, Li J, Summerlin M, Hays A, Katyal S, McKinnon PJ, Nitiss KC, Nitiss JL, Hanakahi LA.

DNA Repair (Amst). 2015 Jun;30:28-37. doi: 10.1016/j.dnarep.2015.03.003. Epub 2015 Mar 17.


Akt-mediated phosphorylation of XLF impairs non-homologous end-joining DNA repair.

Liu P, Gan W, Guo C, Xie A, Gao D, Guo J, Zhang J, Willis N, Su A, Asara JM, Scully R, Wei W.

Mol Cell. 2015 Feb 19;57(4):648-61. doi: 10.1016/j.molcel.2015.01.005. Epub 2015 Feb 5.


Asparagine 326 in the extremely C-terminal region of XRCC4 is essential for the cell survival after irradiation.

Wanotayan R, Fukuchi M, Imamichi S, Sharma MK, Matsumoto Y.

Biochem Biophys Res Commun. 2015 Feb 20;457(4):526-31. doi: 10.1016/j.bbrc.2015.01.015. Epub 2015 Jan 15.


DNA repair. PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair.

Ochi T, Blackford AN, Coates J, Jhujh S, Mehmood S, Tamura N, Travers J, Wu Q, Draviam VM, Robinson CV, Blundell TL, Jackson SP.

Science. 2015 Jan 9;347(6218):185-8. doi: 10.1126/science.1261971.


Ionizing radiation-induced XRCC4 phosphorylation is mediated through ATM in addition to DNA-PK.

Imamichi S, Sharma MK, Kamdar RP, Fukuchi M, Matsumoto Y.

Proc Jpn Acad Ser B Phys Biol Sci. 2014;90(9):365-72.


Hematopoietic stem cell dysfunction underlies the progressive lymphocytopenia in XLF/Cernunnos deficiency.

Avagyan S, Churchill M, Yamamoto K, Crowe JL, Li C, Lee BJ, Zheng T, Mukherjee S, Zha S.

Blood. 2014 Sep 4;124(10):1622-5. doi: 10.1182/blood-2014-05-574863. Epub 2014 Jul 29.


DNA Ligase IV regulates XRCC4 nuclear localization.

Francis DB, Kozlov M, Chavez J, Chu J, Malu S, Hanna M, Cortes P.

DNA Repair (Amst). 2014 Sep;21:36-42. doi: 10.1016/j.dnarep.2014.05.010. Epub 2014 Jun 28.


Novel inhibitor of DNA ligase IV with a promising cancer therapeutic potential.

Kotnis A, Mulherkar R.

J Biosci. 2014 Jun;39(3):339-40. No abstract available.


Unraveling the complexities of DNA-dependent protein kinase autophosphorylation.

Neal JA, Sugiman-Marangos S, VanderVere-Carozza P, Wagner M, Turchi J, Lees-Miller SP, Junop MS, Meek K.

Mol Cell Biol. 2014 Jun;34(12):2162-75. doi: 10.1128/MCB.01554-13. Epub 2014 Mar 31.


DNA-PK: a dynamic enzyme in a versatile DSB repair pathway.

Davis AJ, Chen BP, Chen DJ.

DNA Repair (Amst). 2014 May;17:21-9. doi: 10.1016/j.dnarep.2014.02.020. Epub 2014 Mar 27. Review.


The spatial organization of non-homologous end joining: from bridging to end joining.

Ochi T, Wu Q, Blundell TL.

DNA Repair (Amst). 2014 May;17:98-109. doi: 10.1016/j.dnarep.2014.02.010. Epub 2014 Mar 11.


A role for XLF in DNA repair and recombination in human somatic cells.

Fattah FJ, Kweon J, Wang Y, Lee EH, Kan Y, Lichter N, Weisensel N, Hendrickson EA.

DNA Repair (Amst). 2014 Mar;15:39-53. doi: 10.1016/j.dnarep.2013.12.006. Epub 2014 Jan 21.


C-Terminal region of DNA ligase IV drives XRCC4/DNA ligase IV complex to chromatin.

Liu S, Liu X, Kamdar RP, Wanotayan R, Sharma MK, Adachi N, Matsumoto Y.

Biochem Biophys Res Commun. 2013 Sep 20;439(2):173-8. doi: 10.1016/j.bbrc.2013.08.068. Epub 2013 Aug 28.


Brief report: a human induced pluripotent stem cell model of cernunnos deficiency reveals an important role for XLF in the survival of the primitive hematopoietic progenitors.

Tilgner K, Neganova I, Singhapol C, Saretzki G, Al-Aama JY, Evans J, Gorbunova V, Gennery A, Przyborski S, Stojkovic M, Armstrong L, Jeggo P, Lako M.

Stem Cells. 2013 Sep;31(9):2015-23. doi: 10.1002/stem.1456.


Delineation of key XRCC4/Ligase IV interfaces for targeted disruption of non-homologous end joining DNA repair.

McFadden MJ, Lee WK, Brennan JD, Junop MS.

Proteins. 2014 Feb;82(2):187-94. doi: 10.1002/prot.24349. Epub 2013 Sep 20.


Identification and functional characterization of a Ku-binding motif in aprataxin polynucleotide kinase/phosphatase-like factor (APLF).

Shirodkar P, Fenton AL, Meng L, Koch CA.

J Biol Chem. 2013 Jul 5;288(27):19604-13. doi: 10.1074/jbc.M112.440388. Epub 2013 May 20.


Cooperative assembly of a protein-DNA filament for nonhomologous end joining.

Tsai CJ, Chu G.

J Biol Chem. 2013 Jun 21;288(25):18110-20. doi: 10.1074/jbc.M113.464115. Epub 2013 Apr 25.

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