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Results: 1 to 20 of 342

1.

In vitro metabolism of BIIB021, an inhibitor of heat shock protein 90, in liver microsomes and hepatocytes of rats, dogs, and humans and recombinant human cytochrome P450 isoforms.

Xu L, Woodward C, Khan S, Prakash C.

Drug Metab Dispos. 2012 Apr;40(4):680-93. doi: 10.1124/dmd.111.043000. Epub 2012 Jan 4.

PMID:
22217465
[PubMed - indexed for MEDLINE]
Free Article
2.

Metabolism and excretion of 6-chloro-9-(4-methoxy-3,5-dimethylpyridin-2-ylmethyl)-9H-purin-2-ylamine, an HSP90 inhibitor, in rats and dogs and assessment of its metabolic profile in plasma of humans.

Xu L, Woodward C, Dai J, Prakash C.

Drug Metab Dispos. 2013 Dec;41(12):2133-47. doi: 10.1124/dmd.113.054023. Epub 2013 Sep 17.

PMID:
24046333
[PubMed - indexed for MEDLINE]
4.

Biotransformation of 6-methoxy-3-(3',4',5'-trimethoxy-benzoyl)-1H-indole (BPR0L075), a novel antimicrotubule agent, by mouse, rat, dog, and human liver microsomes.

Yao HT, Wu YS, Chang YW, Hsieh HP, Chen WC, Lan SJ, Chen CT, Chao YS, Chang L, Sun HY, Yeh TK.

Drug Metab Dispos. 2007 Jul;35(7):1042-9. Epub 2007 Apr 2.

PMID:
17403915
[PubMed - indexed for MEDLINE]
Free Article
5.
6.

BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90.

Lundgren K, Zhang H, Brekken J, Huser N, Powell RE, Timple N, Busch DJ, Neely L, Sensintaffar JL, Yang YC, McKenzie A, Friedman J, Scannevin R, Kamal A, Hong K, Kasibhatla SR, Boehm MF, Burrows FJ.

Mol Cancer Ther. 2009 Apr;8(4):921-9. doi: 10.1158/1535-7163.MCT-08-0758.

PMID:
19372565
[PubMed - indexed for MEDLINE]
Free Article
7.

In vitro metabolism of rivaroxaban, an oral, direct factor Xa inhibitor, in liver microsomes and hepatocytes of rats, dogs, and humans.

Lang D, Freudenberger C, Weinz C.

Drug Metab Dispos. 2009 May;37(5):1046-55. doi: 10.1124/dmd.108.025551. Epub 2009 Feb 5.

PMID:
19196846
[PubMed - indexed for MEDLINE]
Free Article
8.

In vitro liver metabolism of aclidinium bromide in preclinical animal species and humans: identification of the human enzymes involved in its oxidative metabolism.

Albertí JJ, Sentellas S, Salvà M.

Biochem Pharmacol. 2011 Mar 15;81(6):761-76. doi: 10.1016/j.bcp.2010.12.013. Epub 2010 Dec 22.

PMID:
21184745
[PubMed - indexed for MEDLINE]
10.

In vitro and in vivo metabolism of a selective δ-opioid receptor.

Guo J, Gu C, Zhou D, Elmore CS, Bui KH, Grimm SW.

Drug Metab Dispos. 2011 Oct;39(10):1883-94. doi: 10.1124/dmd.111.040980. Epub 2011 Jul 13.

PMID:
21752944
[PubMed - indexed for MEDLINE]
Free Article
11.

In vitro assessment of metabolic drug-drug interaction potential of apixaban through cytochrome P450 phenotyping, inhibition, and induction studies.

Wang L, Zhang D, Raghavan N, Yao M, Ma L, Frost CE, Maxwell BD, Chen SY, He K, Goosen TC, Humphreys WG, Grossman SJ.

Drug Metab Dispos. 2010 Mar;38(3):448-58. doi: 10.1124/dmd.109.029694. Epub 2009 Nov 25. Erratum in: Drug Metab Dispos. 2010 May;38(5):887. Frost, Charles A [corrected to Frost, Charles E].

PMID:
19940026
[PubMed - indexed for MEDLINE]
Free Article
12.

Identification of human liver cytochrome P450 enzymes involved in biotransformation of vicriviroc, a CCR5 receptor antagonist.

Ghosal A, Ramanathan R, Yuan Y, Hapangama N, Chowdhury SK, Kishnani NS, Alton KB.

Drug Metab Dispos. 2007 Dec;35(12):2186-95. Epub 2007 Sep 7.

PMID:
17827338
[PubMed - indexed for MEDLINE]
Free Article
14.

Metabolism of prazosin in rat, dog, and human liver microsomes and cryopreserved rat and human hepatocytes and characterization of metabolites by liquid chromatography/tandem mass spectrometry.

Erve JC, Vashishtha SC, DeMaio W, Talaat RE.

Drug Metab Dispos. 2007 Jun;35(6):908-16. Epub 2007 Mar 12.

PMID:
17353349
[PubMed - indexed for MEDLINE]
Free Article
15.

In vitro biotransformation of a novel antimalarial cysteine protease inhibitor in human liver microsomes.

Zhang Y, Guo X, Lin ET, Benet LZ.

Pharmacology. 1999 Mar;58(3):147-59.

PMID:
9925971
[PubMed - indexed for MEDLINE]
16.

In vitro metabolism of oxymetazoline: evidence for bioactivation to a reactive metabolite.

Mahajan MK, Uttamsingh V, Daniels JS, Gan LS, LeDuc BW, Williams DA.

Drug Metab Dispos. 2011 Apr;39(4):693-702. doi: 10.1124/dmd.110.036004. Epub 2010 Dec 21.

PMID:
21177487
[PubMed - indexed for MEDLINE]
Free Article
17.

Role of cytochrome P450 3A in the metabolism of mefloquine in human and animal hepatocytes.

Fontaine F, de Sousa G, Burcham PC, Duchêne P, Rahmani R.

Life Sci. 2000 Apr 21;66(22):2193-212.

PMID:
10834303
[PubMed - indexed for MEDLINE]
18.

Preclinical pharmacokinetics and metabolism of 6-(4-(2,5-difluorophenyl)oxazol-5-yl)-3-isopropyl-[1,2,4]-triazolo[4,3-a]pyridine, a novel and selective p38alpha inhibitor: identification of an active metabolite in preclinical species and human liver microsomes.

Kalgutkar AS, Hatch HL, Kosea F, Nguyen HT, Choo EF, McClure KF, Taylor TJ, Henne KR, Kuperman AV, Dombroski MA, Letavic MA.

Biopharm Drug Dispos. 2006 Nov;27(8):371-86.

PMID:
16944451
[PubMed - indexed for MEDLINE]
19.

Metabolite-P450 complex formation by methylenedioxyphenyl HIV protease inhibitors in rat and human liver microsomes.

Chiba M, Nishime JA, Chen IW, Vastag KJ, Sahly YS, Kim BM, Dorsey BD, Vacca JP, Lin JH.

Biochem Pharmacol. 1998 Jul 15;56(2):223-30.

PMID:
9698076
[PubMed - indexed for MEDLINE]
20.

Metabolism of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in human hepatocytes: 2-amino-3-methylimidazo[4,5-f]quinoxaline-8-carboxylic acid is a major detoxification pathway catalyzed by cytochrome P450 1A2.

Langouët S, Welti DH, Kerriguy N, Fay LB, Huynh-Ba T, Markovic J, Guengerich FP, Guillouzo A, Turesky RJ.

Chem Res Toxicol. 2001 Feb;14(2):211-21. Erratum in: Chem Res Toxicol 2001 May;14(5):609.

PMID:
11258970
[PubMed - indexed for MEDLINE]

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