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22213792,19622817,25391385,22232006,27589522,25162367,29558986,29017593,22475796,24614902,23446677,29387532,16488378,12433260,25322924,22264648,31350262,29054536,11255440,22170879,21460434,23232269,35404281,26923009,27121148,24237038,26147946,23390179,24916543,19273758,30614806,33667602,31805990,17889968,26675344,28317649,25867677,25435336,22503777,21621878,23609762,19768352,26876913,12603251,30430632,9678311,23093013,16274728,25201779,28984585,12709467,26401938,30847669,26401707,29125485,14699432,23110867,27931251,27263933,32415550,23597931,28441967,32039853,29318973,23034521,33843685,26560503,24670397,25716354,21721431,25971633,22057225,28328043,28893185,28948074,21954973,25150736,20547614,21504133,34365256,25159667,25274948,26354982,20555147,23642576,21825215,22281122,26366630,27472875,22517093,26484902,33720890,22045485,26836187,31009028,33682714,31376643,26698298,25844314,31686097,24634832,27567807,30611311,29562515,17698783,31615545,21220682,31683478,30145588,28984603,10505638,21311900,33252070,31801648,24820015,26836160,17210801,26661151,25893879,27567832,17886169,26341365,22233766,25649653,30970371,25468261,29154286,33200589,25668231,31589110,25707998,20930282,35061102,33579852,30253800,29049480,25290083,28527210,28808876,28059783,32144980,23635408,26868820,24705549,30115118,28879085,18700307,30530971,21047883,22210159,26585048,29036824,23019259,30569084,28112948,30958351,34719365,27025083,32029236,25428253,28189924,26468410,29376878,23473966,36002891,30207231,28869470,31511058,30903419,25155658,29171991,27018940,28689050,28527215,22238414,31834392,18806919,29321140,26180139,21841259,33171206,32116257,30791945,32788242,25716355,16020497,35897078,31601267,31179518,22761691,29114726,26967213,27447425,31104027,32450185,19433664,28329084,27163824,28179036,26629677,24913723,30508027,20802215,20043812,24508996,27886009,30547227,23479202,19748159,33104034,10686392,27662296,19833838,21440911,30252906,26599300,30847359,30149454,26256251,28341066,24685624,28826184,20558388,25420549,33773595,26581886,31415236,30967340,27079723,23320095,24595197,33720880,25079805,24779297,31086391,19420940,36368195,34958042,34129723,18525127,12763273,14608585,29370833,24022277,21861669,23186987,25881910,32955460,30654834,27163811,31430334,30579367,22297644,28191798,25121572,31166546,29254094,24239248,33608044,28486988,12603286,21593572,28072416,15136685,19433663,31345148,31010420,26402006,20541287,22580170,37038810,12058089,26401775,30963253,31104024,33814444,30509028,24085246,12909293,25086857,25613100,26923012,25880550,26484922,20075088,26401768,31815692,17318713,30844364,19221425,28139818,22045497,21823155,32542885,29953668,35606871,16870640,23948786,23540941,12411760,11016543,32591471,35068467,27296778,23794434,28213293,31888969,31759396,12909294,30306396,25720397,30155553,10369305,25024322,29959263,24602322,31422798,26677842,26332787,28644588,36880887,20683187,26159200,29321235,30092564,24677154,23484512,22402892,25150733,25990306,29249541,27398953,28726050,32597806,26253588,29017912,26940242,26484901,36120786,26383836,31305322,26803606,27716663,24473733,29439341,28505972,11831556,19160984,23044653,22398375,28826180,32804140,30958346,34739618,27832767,34811435,28235679,23151827,34924386,28482211,26092348,22646065,27934563,27531278,23666171,34283410,29914031,32910550,30419087,30913531,28752420,28269767,30741681,27567848,31744010,14615052,24721526,25061046,31526625,23489287,24132375,31628138,23519967,23070466,22488444,36261295,26827642,25751166,23860482,33998536,18458217,36130840,23313924,29415068,35173015,26836182,26401932,31889402,28527630,27358067,22701578,28719891,35972620,22516280,36324151,35431542,23613741,25596881,31366409,12552068,29554190,26079415,30883350,32947003,26138246,23800368,30814356,33879243,26550994,17612711,29063514,24676441,32255379,29386280,35538065,31424398,36315527,22491869,23909962,36572135,11260625,18057559,27426238,23061918,22954311,31810489,26951396,18931497,35367960,21035623,30054439,24448781,29914023,14505582,25881908,34951383,23576620,33246219,24568931,18631949,25822631,32989109,22576334,17395712,11897565,30958366,27506761,35848017,17098843,27636850,26524180,25424384,35109911,28679595,27589532,33566374,31594235,29641555,36413367,27454922,31371645,36031900,19153649,26147615,30051512,23591828,26475624,26083568,32757819,30317034,12584433,34309155,26757185,33236496,33104030,26333802,34334389,24720893,12218644,33357241,34310832,22105948,26402622,29282337,25646706,25087695,15563479,26718584,31306117,34958910,25411441,24107601,23812320,24002185,33814430,21345847,33814423,21222606,30502079,12614904,35786656,26401704,33252199,29245058,29660934,22303443,23877436,36216518,28341065,21157031,30799255,30021611,30390679,27754941,31055223,22490326,33372192,22890100,29278891,19939224,36800984,28886705,35303916,11351137,30791922,33557920,20813339,28416790,26887322,29684683,21971403,21911695,29857195,26402100,29501462,19609443,30171911,27842175,34397413,35870715,26973507,21998317,20808106,31068481,34310035,341830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Cerebrospinal fluid levels of β-amyloid 1-42, but not of tau, are fully changed already 5 to 10 years before the onset of Alzheimer dementia.

Buchhave P, Minthon L, Zetterberg H, Wallin AK, Blennow K, Hansson O. Buchhave P, et al. Arch Gen Psychiatry. 2012 Jan;69(1):98-106. doi: 10.1001/archgenpsychiatry.2011.155. Arch Gen Psychiatry. 2012. PMID: 22213792

CSF biomarkers and incipient Alzheimer disease in patients with mild cognitive impairment.

Mattsson N, Zetterberg H, Hansson O, Andreasen N, Parnetti L, Jonsson M, Herukka SK, van der Flier WM, Blankenstein MA, Ewers M, Rich K, Kaiser E, Verbeek M, Tsolaki M, Mulugeta E, Rosén E, Aarsland D, Visser PJ, Schröder J, Marcusson J, de Leon M, Hampel H, Scheltens P, Pirttilä T, Wallin A, Jönhagen ME, Minthon L, Winblad B, Blennow K. Mattsson N, et al. JAMA. 2009 Jul 22;302(4):385-93. doi: 10.1001/jama.2009.1064. JAMA. 2009. PMID: 19622817

Cerebrospinal fluid biomarkers distinguish postmortem-confirmed Alzheimer's disease from other dementias and healthy controls in the OPTIMA cohort.

Seeburger JL, Holder DJ, Combrinck M, Joachim C, Laterza O, Tanen M, Dallob A, Chappell D, Snyder K, Flynn M, Simon A, Modur V, Potter WZ, Wilcock G, Savage MJ, Smith AD. Seeburger JL, et al. J Alzheimers Dis. 2015;44(2):525-39. doi: 10.3233/JAD-141725. J Alzheimers Dis. 2015. PMID: 25391385

Performance of aβ1-40, aβ1-42, total tau, and phosphorylated tau as predictors of dementia in a cohort of patients with mild cognitive impairment.

Parnetti L, Chiasserini D, Eusebi P, Giannandrea D, Bellomo G, De Carlo C, Padiglioni C, Mastrocola S, Lisetti V, Calabresi P. Parnetti L, et al. J Alzheimers Dis. 2012;29(1):229-38. doi: 10.3233/JAD-2011-111349. J Alzheimers Dis. 2012. PMID: 22232006

Combining Cerebrospinal Fluid Biomarkers and Neuropsychological Assessment: A Simple and Cost-Effective Algorithm to Predict the Progression from Mild Cognitive Impairment to Alzheimer's Disease Dementia.

Mazzeo S, Santangelo R, Bernasconi MP, Cecchetti G, Fiorino A, Pinto P, Passerini G, Falautano M, Comi G, Magnani G. Mazzeo S, et al. J Alzheimers Dis. 2016 Oct 18;54(4):1495-1508. doi: 10.3233/JAD-160360. J Alzheimers Dis. 2016. PMID: 27589522

Apolipoprotein E genotype and the diagnostic accuracy of cerebrospinal fluid biomarkers for Alzheimer disease.

Lautner R, Palmqvist S, Mattsson N, Andreasson U, Wallin A, Pålsson E, Jakobsson J, Herukka SK, Owenius R, Olsson B, Hampel H, Rujescu D, Ewers M, Landén M, Minthon L, Blennow K, Zetterberg H, Hansson O; Alzheimer’s Disease Neuroimaging Initiative. Lautner R, et al. JAMA Psychiatry. 2014 Oct;71(10):1183-91. doi: 10.1001/jamapsychiatry.2014.1060. JAMA Psychiatry. 2014. PMID: 25162367

Addition of the Aβ42/40 ratio to the cerebrospinal fluid biomarker profile increases the predictive value for underlying Alzheimer's disease dementia in mild cognitive impairment.

Baldeiras I, Santana I, Leitão MJ, Gens H, Pascoal R, Tábuas-Pereira M, Beato-Coelho J, Duro D, Almeida MR, Oliveira CR. Baldeiras I, et al. Alzheimers Res Ther. 2018 Mar 20;10(1):33. doi: 10.1186/s13195-018-0362-2. Alzheimers Res Ther. 2018. PMID: 29558986 Free PMC article.

Incremental value of biomarker combinations to predict progression of mild cognitive impairment to Alzheimer's dementia.

Frölich L, Peters O, Lewczuk P, Gruber O, Teipel SJ, Gertz HJ, Jahn H, Jessen F, Kurz A, Luckhaus C, Hüll M, Pantel J, Reischies FM, Schröder J, Wagner M, Rienhoff O, Wolf S, Bauer C, Schuchhardt J, Heuser I, Rüther E, Henn F, Maier W, Wiltfang J, Kornhuber J. Frölich L, et al. Alzheimers Res Ther. 2017 Oct 10;9(1):84. doi: 10.1186/s13195-017-0301-7. Alzheimers Res Ther. 2017. PMID: 29017593 Free PMC article.

Longitudinal cerebrospinal fluid biomarkers over four years in mild cognitive impairment.

Mattsson N, Portelius E, Rolstad S, Gustavsson M, Andreasson U, Stridsberg M, Wallin A, Blennow K, Zetterberg H. Mattsson N, et al. J Alzheimers Dis. 2012;30(4):767-78. doi: 10.3233/JAD-2012-120019. J Alzheimers Dis. 2012. PMID: 22475796

Additional use of Aβ₄₂/Aβ₄₀ ratio with cerebrospinal fluid biomarkers P-tau and Aβ₄₂ increases the level of evidence of Alzheimer's disease pathophysiological process in routine practice.

Sauvée M, DidierLaurent G, Latarche C, Escanyé MC, Olivier JL, Malaplate-Armand C. Sauvée M, et al. J Alzheimers Dis. 2014;41(2):377-86. doi: 10.3233/JAD-131838. J Alzheimers Dis. 2014. PMID: 24614902

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