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CT perfusion mean transit time maps optimally distinguish benign oligemia from true "at-risk" ischemic penumbra, but thresholds vary by postprocessing technique.

Kamalian S, Kamalian S, Konstas AA, Maas MB, Payabvash S, Pomerantz SR, Schaefer PW, Furie KL, González RG, Lev MH.

AJNR Am J Neuroradiol. 2012 Mar;33(3):545-9. doi: 10.3174/ajnr.A2809. Epub 2011 Dec 22.


Value of perfusion computed tomography in acute ischemic stroke: diagnosis of infarct core and penumbra.

Pan J, Zhang J, Huang W, Cheng X, Ling Y, Dong Q, Geng D.

J Comput Assist Tomogr. 2013 Sep-Oct;37(5):645-9. doi: 10.1097/RCT.0b013e31829866fc.


CT cerebral blood flow maps optimally correlate with admission diffusion-weighted imaging in acute stroke but thresholds vary by postprocessing platform.

Kamalian S, Kamalian S, Maas MB, Goldmacher GV, Payabvash S, Akbar A, Schaefer PW, Furie KL, Gonzalez RG, Lev MH.

Stroke. 2011 Jul;42(7):1923-8. doi: 10.1161/STROKEAHA.110.610618. Epub 2011 May 5.


Differences in CT perfusion summary maps for patients with acute ischemic stroke generated by 2 software packages.

Fahmi F, Marquering HA, Streekstra GJ, Beenen LF, Velthuis BK, VanBavel E, Majoie CB.

AJNR Am J Neuroradiol. 2012 Dec;33(11):2074-80. doi: 10.3174/ajnr.A3110. Epub 2012 May 3.


Arterial input function placement for accurate CT perfusion map construction in acute stroke.

Ferreira RM, Lev MH, Goldmakher GV, Kamalian S, Schaefer PW, Furie KL, Gonzalez RG, Sanelli PC.

AJR Am J Roentgenol. 2010 May;194(5):1330-6. doi: 10.2214/AJR.09.2845.


Perfusion CT in acute stroke: predictive value of perfusion parameters in assessing tissue viability versus infarction.

Sparacia G, Iaia A, Assadi B, Lagalla R.

Radiol Med. 2007 Feb;112(1):113-22. Epub 2007 Feb 22. English, Italian.


Admission CT perfusion is an independent predictor of hemorrhagic transformation in acute stroke with similar accuracy to DWI.

Souza LC, Payabvash S, Wang Y, Kamalian S, Schaefer P, Gonzalez RG, Furie KL, Lev MH.

Cerebrovasc Dis. 2012;33(1):8-15. doi: 10.1159/000331914. Epub 2011 Nov 30.


Cerebral blood flow is the optimal CT perfusion parameter for assessing infarct core.

Campbell BC, Christensen S, Levi CR, Desmond PM, Donnan GA, Davis SM, Parsons MW.

Stroke. 2011 Dec;42(12):3435-40. doi: 10.1161/STROKEAHA.111.618355. Epub 2011 Oct 6.


Whole-brain CT perfusion: reliability and reproducibility of volumetric perfusion deficit assessment in patients with acute ischemic stroke.

Thierfelder KM, Sommer WH, Baumann AB, Klotz E, Meinel FG, Strobl FF, Nikolaou K, Reiser MF, von Baumgarten L.

Neuroradiology. 2013 Jul;55(7):827-35. doi: 10.1007/s00234-013-1179-0. Epub 2013 Apr 9.


Perfusion-CT assessment of infarct core and penumbra: receiver operating characteristic curve analysis in 130 patients suspected of acute hemispheric stroke.

Wintermark M, Flanders AE, Velthuis B, Meuli R, van Leeuwen M, Goldsher D, Pineda C, Serena J, van der Schaaf I, Waaijer A, Anderson J, Nesbit G, Gabriely I, Medina V, Quiles A, Pohlman S, Quist M, Schnyder P, Bogousslavsky J, Dillon WP, Pedraza S.

Stroke. 2006 Apr;37(4):979-85. Epub 2006 Mar 2.


White matter thresholds for ischemic penumbra and infarct core in patients with acute stroke: CT perfusion study.

Murphy BD, Fox AJ, Lee DH, Sahlas DJ, Black SE, Hogan MJ, Coutts SB, Demchuk AM, Goyal M, Aviv RI, Symons S, Gulka IB, Beletsky V, Pelz D, Chan RK, Lee TY.

Radiology. 2008 Jun;247(3):818-25. doi: 10.1148/radiol.2473070551. Epub 2008 Apr 18.


Perfusion computed tomography thresholds defining ischemic penumbra and infarct core: studies in a rat stroke model.

McLeod DD, Parsons MW, Hood R, Hiles B, Allen J, McCann SK, Murtha L, Calford MB, Levi CR, Spratt NJ.

Int J Stroke. 2015 Jun;10(4):553-9. doi: 10.1111/ijs.12147. Epub 2013 Oct 21.


Identification of penumbra and infarct in acute ischemic stroke using computed tomography perfusion-derived blood flow and blood volume measurements.

Murphy BD, Fox AJ, Lee DH, Sahlas DJ, Black SE, Hogan MJ, Coutts SB, Demchuk AM, Goyal M, Aviv RI, Symons S, Gulka IB, Beletsky V, Pelz D, Hachinski V, Chan R, Lee TY.

Stroke. 2006 Jul;37(7):1771-7. Epub 2006 Jun 8.


Association of CT perfusion parameters with hemorrhagic transformation in acute ischemic stroke.

Jain AR, Jain M, Kanthala AR, Damania D, Stead LG, Wang HZ, Jahromi BS.

AJNR Am J Neuroradiol. 2013 Oct;34(10):1895-900. doi: 10.3174/ajnr.A3502. Epub 2013 Apr 18.


Acute stroke: a comparison of different CT perfusion algorithms and validation of ischaemic lesions by follow-up imaging.

Abels B, Villablanca JP, Tomandl BF, Uder M, Lell MM.

Eur Radiol. 2012 Dec;22(12):2559-67. doi: 10.1007/s00330-012-2529-8. Epub 2012 Jun 21.


Delay-sensitive and delay-insensitive deconvolution perfusion-CT: similar ischemic core and penumbra volumes if appropriate threshold selected for each.

Man F, Patrie JT, Xin W, Zhu G, Hou Q, Michel P, Eskandari A, Jovin T, Xian J, Wang Z, Wintermark M.

Neuroradiology. 2015 Jun;57(6):573-81. doi: 10.1007/s00234-015-1507-7. Epub 2015 Mar 7.


Clinical use of computed tomographic perfusion for the diagnosis and prediction of lesion growth in acute ischemic stroke.

Huisa BN, Neil WP, Schrader R, Maya M, Pereira B, Bruce NT, Lyden PD.

J Stroke Cerebrovasc Dis. 2014 Jan;23(1):114-22. doi: 10.1016/j.jstrokecerebrovasdis.2012.10.020. Epub 2012 Dec 14.


Reliability of CT perfusion in the evaluation of the ischaemic penumbra.

Alves JE, Carneiro Â, Xavier J.

Neuroradiol J. 2014 Feb;27(1):91-5. Epub 2014 Feb 24.


Viability thresholds of ischemic penumbra of hyperacute stroke defined by perfusion-weighted MRI and apparent diffusion coefficient.

Røhl L, Ostergaard L, Simonsen CZ, Vestergaard-Poulsen P, Andersen G, Sakoh M, Le Bihan D, Gyldensted C.

Stroke. 2001 May;32(5):1140-6.


Time-Dependent Computed Tomographic Perfusion Thresholds for Patients With Acute Ischemic Stroke.

d'Esterre CD, Boesen ME, Ahn SH, Pordeli P, Najm M, Minhas P, Davari P, Fainardi E, Rubiera M, Khaw AV, Zini A, Frayne R, Hill MD, Demchuk AM, Sajobi TT, Forkert ND, Goyal M, Lee TY, Menon BK.

Stroke. 2015 Dec;46(12):3390-7. doi: 10.1161/STROKEAHA.115.009250. Epub 2015 Oct 29.

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