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Phosphorylation sites in the cerebral cavernous malformations complex.

Kim J, Sherman NE, Fox JW, Ginsberg MH.

J Cell Sci. 2011 Dec 1;124(Pt 23):3929-32. doi: 10.1242/jcs.095471. No abstract available.


CCM3 interacts with CCM2 indicating common pathogenesis for cerebral cavernous malformations.

Voss K, Stahl S, Schleider E, Ullrich S, Nickel J, Mueller TD, Felbor U.

Neurogenetics. 2007 Nov;8(4):249-56. Epub 2007 Jul 27.


CCM3 signaling through sterile 20-like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations.

Zheng X, Xu C, Di Lorenzo A, Kleaveland B, Zou Z, Seiler C, Chen M, Cheng L, Xiao J, He J, Pack MA, Sessa WC, Kahn ML.

J Clin Invest. 2010 Aug;120(8):2795-804. doi: 10.1172/JCI39679. Epub 2010 Jul 1.


Mechanism for KRIT1 release of ICAP1-mediated suppression of integrin activation.

Liu W, Draheim KM, Zhang R, Calderwood DA, Boggon TJ.

Mol Cell. 2013 Feb 21;49(4):719-29. doi: 10.1016/j.molcel.2012.12.005. Epub 2013 Jan 11.


Functional analyses of human and zebrafish 18-amino acid in-frame deletion pave the way for domain mapping of the cerebral cavernous malformation 3 protein.

Voss K, Stahl S, Hogan BM, Reinders J, Schleider E, Schulte-Merker S, Felbor U.

Hum Mutat. 2009 Jun;30(6):1003-11. doi: 10.1002/humu.20996.


Structural and functional differences between KRIT1A and KRIT1B isoforms: a framework for understanding CCM pathogenesis.

Francalanci F, Avolio M, De Luca E, Longo D, Menchise V, Guazzi P, Sgrò F, Marino M, Goitre L, Balzac F, Trabalzini L, Retta SF.

Exp Cell Res. 2009 Jan 15;315(2):285-303. doi: 10.1016/j.yexcr.2008.10.006. Epub 2008 Oct 21.


The structure of the ternary complex of Krev interaction trapped 1 (KRIT1) bound to both the Rap1 GTPase and the heart of glass (HEG1) cytoplasmic tail.

Gingras AR, Puzon-McLaughlin W, Ginsberg MH.

J Biol Chem. 2013 Aug 16;288(33):23639-49. doi: 10.1074/jbc.M113.462911. Epub 2013 Jun 27.


Signaling pathways and the cerebral cavernous malformations proteins: lessons from structural biology.

Fisher OS, Boggon TJ.

Cell Mol Life Sci. 2014 May;71(10):1881-92. doi: 10.1007/s00018-013-1532-9. Epub 2013 Nov 29. Review.


Biallelic somatic and germline mutations in cerebral cavernous malformations (CCMs): evidence for a two-hit mechanism of CCM pathogenesis.

Akers AL, Johnson E, Steinberg GK, Zabramski JM, Marchuk DA.

Hum Mol Genet. 2009 Mar 1;18(5):919-30. doi: 10.1093/hmg/ddn430. Epub 2008 Dec 16.


Structural mechanism of CCM3 heterodimerization with GCKIII kinases.

Zhang M, Dong L, Shi Z, Jiao S, Zhang Z, Zhang W, Liu G, Chen C, Feng M, Hao Q, Wang W, Yin M, Zhao Y, Zhang L, Zhou Z.

Structure. 2013 Apr 2;21(4):680-8.


The guanylate kinase domain of the MAGUK PSD-95 binds dynamically to a conserved motif in MAP1a.

Reese ML, Dakoji S, Bredt DS, Dötsch V.

Nat Struct Mol Biol. 2007 Feb;14(2):155-63. Epub 2007 Jan 14.


[Genetics of cerebral cavernous malformations (CCM)].

Felbor U.

Dtsch Med Wochenschr. 2007 Sep;132(38):1967-70. Review. German. No abstract available.


Novel CCM1, CCM2, and CCM3 mutations in patients with cerebral cavernous malformations: in-frame deletion in CCM2 prevents formation of a CCM1/CCM2/CCM3 protein complex.

Stahl S, Gaetzner S, Voss K, Brackertz B, Schleider E, Sürücü O, Kunze E, Netzer C, Korenke C, Finckh U, Habek M, Poljakovic Z, Elbracht M, Rudnik-Schöneborn S, Bertalanffy H, Sure U, Felbor U.

Hum Mutat. 2008 May;29(5):709-17. doi: 10.1002/humu.20712.


Structural basis for small G protein effector interaction of Ras-related protein 1 (Rap1) and adaptor protein Krev interaction trapped 1 (KRIT1).

Li X, Zhang R, Draheim KM, Liu W, Calderwood DA, Boggon TJ.

J Biol Chem. 2012 Jun 22;287(26):22317-27. doi: 10.1074/jbc.M112.361295. Epub 2012 May 10.


Cocrystal structure of the ICAP1 PTB domain in complex with a KRIT1 peptide.

Liu W, Boggon TJ.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 May 1;69(Pt 5):494-8. doi: 10.1107/S1744309113010762. Epub 2013 Apr 27.


A two-hit mechanism causes cerebral cavernous malformations: complete inactivation of CCM1, CCM2 or CCM3 in affected endothelial cells.

Pagenstecher A, Stahl S, Sure U, Felbor U.

Hum Mol Genet. 2009 Mar 1;18(5):911-8. doi: 10.1093/hmg/ddn420. Epub 2008 Dec 16.


The chaperone protein 14-3-3 interacts with 3BP2/SH3BP2 and regulates its adapter function.

Foucault I, Liu YC, Bernard A, Deckert M.

J Biol Chem. 2003 Feb 28;278(9):7146-53. Epub 2002 Dec 24.


KRIT1 association with the integrin-binding protein ICAP-1: a new direction in the elucidation of cerebral cavernous malformations (CCM1) pathogenesis.

Zawistowski JS, Serebriiskii IG, Lee MF, Golemis EA, Marchuk DA.

Hum Mol Genet. 2002 Feb 15;11(4):389-96.

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