Display Settings:

Format
Items per page
Sort by

Send to:

Choose Destination

Results: 1 to 20 of 94

1.

Synthesis and toxicopharmacological evaluation of m-hydroxymexiletine, the first metabolite of mexiletine more potent than the parent compound on voltage-gated sodium channels.

Catalano A, Desaphy JF, Lentini G, Carocci A, Di Mola A, Bruno C, Carbonara R, De Palma A, Budriesi R, Ghelardini C, Perrone MG, Colabufo NA, Conte Camerino D, Franchini C.

J Med Chem. 2012 Feb 9;55(3):1418-22. doi: 10.1021/jm201197z. Epub 2012 Jan 31.

PMID:
22191686
[PubMed - indexed for MEDLINE]
2.

An improved synthesis of m-hydroxymexiletine, a potent mexiletine metabolite.

Catalano A, Carocci A, Lentini G, Defrenza I, Cavalluzzi MM, Franchini C.

Drug Metab Lett. 2012 Jun 1;6(2):124-8.

PMID:
22849704
[PubMed - indexed for MEDLINE]
3.

Searching for new antiarrhythmic agents: evaluation of meta-hydroxymexiletine enantiomers.

Catalano A, Budriesi R, Bruno C, Di Mola A, Defrenza I, Cavalluzzi MM, Micucci M, Carocci A, Franchini C, Lentini G.

Eur J Med Chem. 2013 Jul;65:511-6. doi: 10.1016/j.ejmech.2013.05.008. Epub 2013 May 18.

PMID:
23777871
[PubMed - indexed for MEDLINE]
4.

Stereospecific synthesis of m-Hydroxymexiletine enantiomers.

Catalano A, Carocci A, Lentini G, Defrenza I, Bruno C, Franchini C.

Drug Metab Lett. 2012 Sep 1;6(3):182-6.

PMID:
23140556
[PubMed - indexed for MEDLINE]
5.

Stereospecific synthesis of "para-hydroxymexiletine" and sodium channel blocking activity evaluation.

Catalano A, Carocci A, Fracchiolla G, Franchini C, Lentini G, Tortorella V, De Luca A, De Bellis M, Desaphy JF, Conte Camerino D.

Chirality. 2004 Feb;16(2):72-8. Erratum in: Chirality. 2005 May 15;17(5):297.

PMID:
14712469
[PubMed - indexed for MEDLINE]
6.

Optically active mexiletine analogues as stereoselective blockers of voltage-gated Na(+) channels.

Franchini C, Carocci A, Catalano A, Cavalluzzi MM, Corbo F, Lentini G, Scilimati A, Tortorella P, Camerino DC, De Luca A.

J Med Chem. 2003 Nov 20;46(24):5238-48. Erratum in: J Med Chem. 2005 Apr 21;48(8):3094.

PMID:
14613326
[PubMed - indexed for MEDLINE]
7.

Hydroxylated analogs of mexiletine as tools for structural-requirements investigation of the sodium channel blocking activity.

Catalano A, Carocci A, Cavalluzzi MM, Di Mola A, Lentini G, Lovece A, Dipalma A, Costanza T, Desaphy JF, Conte Camerino D, Franchini C.

Arch Pharm (Weinheim). 2010 Jun;343(6):325-32. doi: 10.1002/ardp.200900218.

PMID:
20509146
[PubMed - indexed for MEDLINE]
8.

Design and assessment of a potent sodium channel blocking derivative of mexiletine for minimizing experimental neuropathic pain in several rat models.

Weston RM, Subasinghe KR, Staikopoulos V, Jarrott B.

Neurochem Res. 2009 Oct;34(10):1816-23. doi: 10.1007/s11064-009-0012-y. Epub 2009 Jun 6.

PMID:
19504185
[PubMed - indexed for MEDLINE]
9.

Differential interaction of R-mexiletine with the local anesthetic receptor site on brain and heart sodium channel alpha-subunits.

Weiser T, Qu Y, Catterall WA, Scheuer T.

Mol Pharmacol. 1999 Dec;56(6):1238-44.

PMID:
10570051
[PubMed - indexed for MEDLINE]
Free Article
10.

Meta-hydroxymexiletine, a new metabolite of mexiletine. Isolation, characterization, and species differences in its formation.

Grech-Bélanger O, Turgeon J, Lalande M, Bélanger PM.

Drug Metab Dispos. 1991 Mar-Apr;19(2):458-61.

PMID:
1676654
[PubMed - indexed for MEDLINE]
11.

Evaluation of the antimyotonic activity of mexiletine and some new analogs on sodium currents of single muscle fibers and on the abnormal excitability of the myotonic ADR mouse.

De Luca A, Pierno S, Natuzzi F, Franchini C, Duranti A, Lentini G, Tortorella V, Jockusch H, Camerino DC.

J Pharmacol Exp Ther. 1997 Jul;282(1):93-100.

PMID:
9223544
[PubMed - indexed for MEDLINE]
Free Article
12.

Stereoselective metabolism of rac-mexiletine by the fungus Cunninghamella echinulata yields the major human metabolites hydroxymethylmexiletine and p-hydroxymexiletine.

Freitag DG, Foster RT, Coutts RT, Pickard MA, Pasutto FM.

Drug Metab Dispos. 1997 Jun;25(6):685-92.

PMID:
9193869
[PubMed - indexed for MEDLINE]
Free Article
13.

Evaluation of the pharmacological activity of the major mexiletine metabolites on skeletal muscle sodium currents.

De Bellis M, De Luca A, Rana F, Cavalluzzi MM, Catalano A, Lentini G, Franchini C, Tortorella V, Conte Camerino D.

Br J Pharmacol. 2006 Oct;149(3):300-10. Epub 2006 Aug 21.

PMID:
16921388
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Synthesis and in vitro sodium channel blocking activity evaluation of novel homochiral mexiletine analogs.

Carocci A, Catalano A, Bruno C, Lentini G, Franchini C, De Bellis M, De Luca A, Conte Camerino D.

Chirality. 2010 Mar;22(3):299-307. doi: 10.1002/chir.20741.

PMID:
19544349
[PubMed - indexed for MEDLINE]
15.

Gating of myotonic Na channel mutants defines the response to mexiletine and a potent derivative.

Desaphy JF, De Luca A, Tortorella P, De Vito D, George AL Jr, Conte Camerino D.

Neurology. 2001 Nov 27;57(10):1849-57.

PMID:
11723275
[PubMed - indexed for MEDLINE]
16.

Role of K+ channels in augmented relaxations to sodium nitroprusside induced by mexiletine in rat aortas.

Kinoshita H, Ishikawa T, Hatano Y.

Anesthesiology. 2000 Mar;92(3):813-20.

PMID:
10719960
[PubMed - indexed for MEDLINE]
Free Article
17.

Inhibition of frog skeletal muscle sodium channels by newly synthesized chiral derivatives of mexiletine and tocainide.

De Luca A, Natuzzi F, Falcone G, Duranti A, Lentini G, Franchini C, Tortorella V, Camerino DC.

Naunyn Schmiedebergs Arch Pharmacol. 1997 Dec;356(6):777-87.

PMID:
9453464
[PubMed - indexed for MEDLINE]
18.

A combination of inactivated sodium channel blockers causes competitive interaction on dV/dtmax of single ventricular myocytes.

Kamiya K, Kodama I, Toyama J.

Cardiovasc Res. 1991 Jun;25(6):516-22.

PMID:
1653644
[PubMed - indexed for MEDLINE]
19.

New potent mexiletine and tocainide analogues evaluated in vivo and in vitro as antimyotonic agents on the myotonic ADR mouse.

De Luca A, Pierno S, Liantonio A, Desaphy JF, Natuzzi F, Didonna MP, Ferrannini E, Jockusch H, Franchini C, Lentini G, Corbo F, Tortorella V, Camerino DC.

Neuromuscul Disord. 2004 Jul;14(7):405-16.

PMID:
15210163
[PubMed - indexed for MEDLINE]
20.

Electrocardiographic interactions between pinacidil, a potassium channel opener and class I antiarrhythmic agents in guinea-pig isolated perfused heart.

Yang Q, Padrini R, Bova S, Piovan D, Magnolfi G.

Br J Pharmacol. 1995 Apr;114(8):1745-9.

PMID:
7599944
[PubMed - indexed for MEDLINE]
Free PMC Article

Display Settings:

Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

Write to the Help Desk