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Results: 1 to 20 of 358

1.

Gi-biased β2AR signaling links GRK2 upregulation to heart failure.

Zhu W, Petrashevskaya N, Ren S, Zhao A, Chakir K, Gao E, Chuprun JK, Wang Y, Talan M, Dorn GW 2nd, Lakatta EG, Koch WJ, Feldman AM, Xiao RP.

Circ Res. 2012 Jan 20;110(2):265-74. doi: 10.1161/CIRCRESAHA.111.253260. Epub 2011 Dec 15.

PMID:
22179058
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Agonist dose-dependent phosphorylation by protein kinase A and G protein-coupled receptor kinase regulates beta2 adrenoceptor coupling to G(i) proteins in cardiomyocytes.

Liu R, Ramani B, Soto D, De Arcangelis V, Xiang Y.

J Biol Chem. 2009 Nov 20;284(47):32279-87. doi: 10.1074/jbc.M109.021428. Epub 2009 Aug 25.

PMID:
19706594
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Norepinephrine- and epinephrine-induced distinct beta2-adrenoceptor signaling is dictated by GRK2 phosphorylation in cardiomyocytes.

Wang Y, De Arcangelis V, Gao X, Ramani B, Jung YS, Xiang Y.

J Biol Chem. 2008 Jan 25;283(4):1799-807. Epub 2007 Dec 3.

PMID:
18056263
[PubMed - indexed for MEDLINE]
Free Article
4.

Inhibition of spontaneous beta 2-adrenergic activation rescues beta 1-adrenergic contractile response in cardiomyocytes overexpressing beta 2-adrenoceptor.

Zhang SJ, Cheng H, Zhou YY, Wang DJ, Zhu W, Ziman B, Spurgoen H, Lefkowitz RJ, Lakatta EG, Koch WJ, Xiao RP.

J Biol Chem. 2000 Jul 14;275(28):21773-9.

PMID:
10787424
[PubMed - indexed for MEDLINE]
Free Article
5.

RGS2 is a primary terminator of β₂-adrenergic receptor-mediated G(i) signaling.

Chakir K, Zhu W, Tsang S, Woo AY, Yang D, Wang X, Zeng X, Rhee MH, Mende U, Koitabashi N, Takimoto E, Blumer KJ, Lakatta EG, Kass DA, Xiao RP.

J Mol Cell Cardiol. 2011 Jun;50(6):1000-7. doi: 10.1016/j.yjmcc.2011.01.015. Epub 2011 Feb 1.

PMID:
21291891
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

G alpha(q)-mediated activation of GRK2 by mechanical stretch in cardiac myocytes: the role of protein kinase C.

Malhotra R, D'Souza KM, Staron ML, Birukov KG, Bodi I, Akhter SA.

J Biol Chem. 2010 Apr 30;285(18):13748-60. doi: 10.1074/jbc.M110.109272. Epub 2010 Mar 1.

PMID:
20194499
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Enhanced G(i) signaling selectively negates beta2-adrenergic receptor (AR)--but not beta1-AR-mediated positive inotropic effect in myocytes from failing rat hearts.

Xiao RP, Zhang SJ, Chakir K, Avdonin P, Zhu W, Bond RA, Balke CW, Lakatta EG, Cheng H.

Circulation. 2003 Sep 30;108(13):1633-9. Epub 2003 Sep 15.

PMID:
12975249
[PubMed - indexed for MEDLINE]
Free Article
8.

Gβγ-independent recruitment of G-protein coupled receptor kinase 2 drives tumor necrosis factor α-induced cardiac β-adrenergic receptor dysfunction.

Vasudevan NT, Mohan ML, Gupta MK, Martelli EE, Hussain AK, Qin Y, Chandrasekharan UM, Young D, Feldman AM, Sen S, Dorn GW 2nd, Dicorleto PE, Naga Prasad SV.

Circulation. 2013 Jul 23;128(4):377-87. doi: 10.1161/CIRCULATIONAHA.113.003183. Epub 2013 Jun 19.

PMID:
23785004
[PubMed - indexed for MEDLINE]
9.

Hybrid transgenic mice reveal in vivo specificity of G protein-coupled receptor kinases in the heart.

Eckhart AD, Duncan SJ, Penn RB, Benovic JL, Lefkowitz RJ, Koch WJ.

Circ Res. 2000 Jan 7-21;86(1):43-50.

PMID:
10625304
[PubMed - indexed for MEDLINE]
Free Article
11.

G protein-coupled receptor kinase 2 ablation in cardiac myocytes before or after myocardial infarction prevents heart failure.

Raake PW, Vinge LE, Gao E, Boucher M, Rengo G, Chen X, DeGeorge BR Jr, Matkovich S, Houser SR, Most P, Eckhart AD, Dorn GW 2nd, Koch WJ.

Circ Res. 2008 Aug 15;103(4):413-22. doi: 10.1161/CIRCRESAHA.107.168336. Epub 2008 Jul 17.

PMID:
18635825
[PubMed - indexed for MEDLINE]
Free PMC Article
12.
13.

β-adrenergic signaling inhibits Gq-dependent protein kinase D activation by preventing protein kinase D translocation.

Nichols CB, Chang CW, Ferrero M, Wood BM, Stein ML, Ferguson AJ, Ha D, Rigor RR, Bossuyt S, Bossuyt J.

Circ Res. 2014 Apr 25;114(9):1398-409. doi: 10.1161/CIRCRESAHA.114.303870. Epub 2014 Mar 18.

PMID:
24643961
[PubMed - indexed for MEDLINE]
14.

Protein kinase A-mediated phosphorylation of the beta 2-adrenergic receptor regulates its coupling to Gs and Gi. Demonstration in a reconstituted system.

Zamah AM, Delahunty M, Luttrell LM, Lefkowitz RJ.

J Biol Chem. 2002 Aug 23;277(34):31249-56. Epub 2002 Jun 12.

PMID:
12063255
[PubMed - indexed for MEDLINE]
Free Article
15.

GRK2 blockade with βARKct is essential for cardiac β2-adrenergic receptor signaling towards increased contractility.

Salazar NC, Vallejos X, Siryk A, Rengo G, Cannavo A, Liccardo D, De Lucia C, Gao E, Leosco D, Koch WJ, Lymperopoulos A.

Cell Commun Signal. 2013 Aug 28;11:64. doi: 10.1186/1478-811X-11-64.

PMID:
23984976
[PubMed - indexed for MEDLINE]
Free PMC Article
16.
17.

Phosphatidylinositol 3-kinase offsets cAMP-mediated positive inotropic effect via inhibiting Ca2+ influx in cardiomyocytes.

Leblais V, Jo SH, Chakir K, Maltsev V, Zheng M, Crow MT, Wang W, Lakatta EG, Xiao RP.

Circ Res. 2004 Dec 10;95(12):1183-90. Epub 2004 Nov 11.

PMID:
15539636
[PubMed - indexed for MEDLINE]
Free Article
18.

Cardiotoxic and cardioprotective features of chronic β-adrenergic signaling.

Zhang X, Szeto C, Gao E, Tang M, Jin J, Fu Q, Makarewich C, Ai X, Li Y, Tang A, Wang J, Gao H, Wang F, Ge XJ, Kunapuli SP, Zhou L, Zeng C, Xiang KY, Chen X.

Circ Res. 2013 Feb 1;112(3):498-509. doi: 10.1161/CIRCRESAHA.112.273896. Epub 2012 Oct 25.

PMID:
23104882
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Coupling of beta2-adrenoceptor to Gi proteins and its physiological relevance in murine cardiac myocytes.

Xiao RP, Avdonin P, Zhou YY, Cheng H, Akhter SA, Eschenhagen T, Lefkowitz RJ, Koch WJ, Lakatta EG.

Circ Res. 1999 Jan 8-22;84(1):43-52.

PMID:
9915773
[PubMed - indexed for MEDLINE]
Free Article
20.

Phosphatidylinositol 3-kinase functionally compartmentalizes the concurrent G(s) signaling during beta2-adrenergic stimulation.

Jo SH, Leblais V, Wang PH, Crow MT, Xiao RP.

Circ Res. 2002 Jul 12;91(1):46-53.

PMID:
12114321
[PubMed - indexed for MEDLINE]
Free Article

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