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Results: 1 to 20 of 90

1.

Novel substituted pyrimidines as HCV replication (replicase) inhibitors.

Kwong CD, Clark JL, Fowler AT, Geng F, Kezar HS 3rd, Roychowdhury A, Reynolds RC, Maddry JA, Ananthan S, Secrist JA 3rd, Shih NY, Piwinski JJ, Li C, Feld B, Huang HC, Tong X, George Njoroge F, Arasappan A.

Bioorg Med Chem Lett. 2012 Jan 15;22(2):1160-4. doi: 10.1016/j.bmcl.2011.11.091. Epub 2011 Dec 1.

PMID:
22178556
[PubMed - indexed for MEDLINE]
2.

Synthesis and SAR of pyridothiazole substituted pyrimidine derived HCV replication inhibitors.

Girijavallabhan VM, Alvarez C, Bennett F, Chen L, Gavalas S, Huang Y, Kim SH, Kosinski A, Pinto P, Rizvi R, Rossman R, Shankar B, Tong L, Velazquez F, Venkatraman S, Verma VA, Kozlowski J, Shih NY, Piwinski JJ, MacCoss M, Kwong CD, Bansal N, Clark JL, Fowler AT, Kezar HS 3rd, Valiyaveettil J, Reynolds RC, Maddry JA, Ananthan S, Secrist JA 3rd, Li C, Chase R, Curry S, Huang HC, Tong X, Njoroge FG, Arasappan A.

Bioorg Med Chem Lett. 2012 Sep 1;22(17):5652-7. doi: 10.1016/j.bmcl.2012.06.099. Epub 2012 Jul 15.

PMID:
22858143
[PubMed - indexed for MEDLINE]
3.

5-Benzothiazole substituted pyrimidine derivatives as HCV replication (replicase) inhibitors.

Arasappan A, Bennett F, Girijavallabhan V, Huang Y, Huelgas R, Alvarez C, Chen L, Gavalas S, Kim SH, Kosinski A, Pinto P, Rizvi R, Rossman R, Shankar B, Tong L, Velazquez F, Venkatraman S, Verma VA, Kozlowski J, Shih NY, Piwinski JJ, MacCoss M, Kwong CD, Clark JL, Fowler AT, Geng F, Kezar HS 3rd, Roychowdhury A, Reynolds RC, Maddry JA, Ananthan S, Secrist JA 3rd, Li C, Chase R, Curry S, Huang HC, Tong X, Njoroge FG.

Bioorg Med Chem Lett. 2012 May 1;22(9):3229-34. doi: 10.1016/j.bmcl.2012.03.036. Epub 2012 Mar 13.

PMID:
22472692
[PubMed - indexed for MEDLINE]
4.

Pyridofuran substituted pyrimidine derivatives as HCV replication (replicase) inhibitors.

Bennett F, Kezar HS 3rd, Girijavallabhan V, Huang Y, Huelgas R, Rossman R, Shih NY, Piwinski JJ, MacCoss M, Kwong CD, Clark JL, Fowler AT, Geng F, Roychowdhury A, Reynolds RC, Maddry JA, Ananthan S, Secrist JA 3rd, Li C, Chase R, Curry S, Huang HC, Tong X, George Njoroge F, Arasappan A.

Bioorg Med Chem Lett. 2012 Aug 1;22(15):5144-9. doi: 10.1016/j.bmcl.2012.06.021. Epub 2012 Jun 19.

PMID:
22814211
[PubMed - indexed for MEDLINE]
5.

Novel hepatitis C virus replicon inhibitors: synthesis and structure-activity relationships of fused pyrimidine derivatives.

Krueger AC, Madigan DL, Beno DW, Betebenner DA, Carrick R, Green BE, He W, Liu D, Maring CJ, McDaniel KF, Mo H, Molla A, Motter CE, Pilot-Matias TJ, Tufano MD, Kempf DJ.

Bioorg Med Chem Lett. 2012 Mar 15;22(6):2212-5. doi: 10.1016/j.bmcl.2012.01.096. Epub 2012 Feb 2.

PMID:
22342631
[PubMed - indexed for MEDLINE]
6.

Nucleoside analog inhibitors of hepatitis C virus replication.

Carroll SS, Olsen DB.

Infect Disord Drug Targets. 2006 Mar;6(1):17-29. Review.

PMID:
16787301
[PubMed - indexed for MEDLINE]
7.

Discovery of novel HCV inhibitors: synthesis and biological activity of 6-(indol-2-yl)pyridine-3-sulfonamides targeting hepatitis C virus NS4B.

Zhang X, Zhang N, Chen G, Turpoff A, Ren H, Takasugi J, Morrill C, Zhu J, Li C, Lennox W, Paget S, Liu Y, Almstead N, Njoroge FG, Gu Z, Komatsu T, Clausen V, Espiritu C, Graci J, Colacino J, Lahser F, Risher N, Weetall M, Nomeir A, Karp GM.

Bioorg Med Chem Lett. 2013 Jul 1;23(13):3947-53. doi: 10.1016/j.bmcl.2013.04.049. Epub 2013 Apr 30.

PMID:
23683597
[PubMed - indexed for MEDLINE]
8.

Discovery and characterization of substituted diphenyl heterocyclic compounds as potent and selective inhibitors of hepatitis C virus replication.

Huang P, Goff DA, Huang Q, Martinez A, Xu X, Crowder S, Issakani SD, Anderson E, Sheng N, Achacoso P, Yen A, Kinsella T, Darwish IS, Kolluri R, Hong H, Qu K, Stauffer E, Goldstein E, Singh R, Payan DG, Lu HH.

Antimicrob Agents Chemother. 2008 Apr;52(4):1419-29. doi: 10.1128/AAC.00525-07. Epub 2008 Jan 28.

PMID:
18227176
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

2'-deoxy-4'-azido nucleoside analogs are highly potent inhibitors of hepatitis C virus replication despite the lack of 2'-alpha-hydroxyl groups.

Klumpp K, Kalayanov G, Ma H, Le Pogam S, Leveque V, Jiang WR, Inocencio N, De Witte A, Rajyaguru S, Tai E, Chanda S, Irwin MR, Sund C, Winqist A, Maltseva T, Eriksson S, Usova E, Smith M, Alker A, Najera I, Cammack N, Martin JA, Johansson NG, Smith DB.

J Biol Chem. 2008 Jan 25;283(4):2167-75. Epub 2007 Nov 14.

PMID:
18003608
[PubMed - indexed for MEDLINE]
Free Article
10.

Discovery of N-(4'-(indol-2-yl)phenyl)sulfonamides as novel inhibitors of HCV replication.

Chen G, Ren H, Turpoff A, Arefolov A, Wilde R, Takasugi J, Khan A, Almstead N, Gu Z, Komatsu T, Freund C, Breslin J, Colacino J, Hedrick J, Weetall M, Karp GM.

Bioorg Med Chem Lett. 2013 Jul 1;23(13):3942-6. doi: 10.1016/j.bmcl.2013.04.050. Epub 2013 Apr 30.

PMID:
23683596
[PubMed - indexed for MEDLINE]
11.

Exploration of the in vitro antiviral activity of a series of new pyrimidine analogues on the replication of HIV and HCV.

Jafar NN, Al-Masoudi NA, Baqir SJ, Leyssen P, Pannecouque C.

Antivir Chem Chemother. 2012 Sep 25;23(3):103-12. doi: 10.3851/IMP2400.

PMID:
23010622
[PubMed - indexed for MEDLINE]
12.

Discovery and characterization of a novel 7-aminopyrazolo[1,5-a]pyrimidine analog as a potent hepatitis C virus inhibitor.

Hwang JY, Windisch MP, Jo S, Kim K, Kong S, Kim HC, Kim S, Kim H, Lee ME, Kim Y, Choi J, Park DS, Park E, Kwon J, Nam J, Ahn S, Cechetto J, Kim J, Liuzzi M, No Z, Lee J.

Bioorg Med Chem Lett. 2012 Dec 15;22(24):7297-301. doi: 10.1016/j.bmcl.2012.10.123. Epub 2012 Nov 5.

PMID:
23159569
[PubMed - indexed for MEDLINE]
13.

Synthesis and antiviral evaluation of 2'-C-methyl analogues of 5-alkynyl- and 6-alkylfurano- and pyrrolo[2,3-d]pyrimidine ribonucleosides.

Januszczyk P, Fogt J, Boryski J, Izawa K, Onishi T, Neyts J, De Clercq E.

Nucleosides Nucleotides Nucleic Acids. 2009 May;28(5):713-23. doi: 10.1080/15257770903128870.

PMID:
20183611
[PubMed - indexed for MEDLINE]
14.

Development of a cell-based assay for high-throughput screening of inhibitors against HCV genotypes 1a and 1b in a single well.

Mondal R, Koev G, Pilot-Matias T, He Y, Ng T, Kati W, Molla A.

Antiviral Res. 2009 Apr;82(1):82-8. doi: 10.1016/j.antiviral.2008.12.012. Epub 2009 Jan 25.

PMID:
19174175
[PubMed - indexed for MEDLINE]
15.

Discovery of (7R)-14-cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylic acid (MK-3281), a potent and orally bioavailable finger-loop inhibitor of the hepatitis C virus NS5B polymerase.

Narjes F, Crescenzi B, Ferrara M, Habermann J, Colarusso S, Ferreira Mdel R, Stansfield I, Mackay AC, Conte I, Ercolani C, Zaramella S, Palumbi MC, Meuleman P, Leroux-Roels G, Giuliano C, Fiore F, Di Marco S, Baiocco P, Koch U, Migliaccio G, Altamura S, Laufer R, De Francesco R, Rowley M.

J Med Chem. 2011 Jan 13;54(1):289-301. doi: 10.1021/jm1013105. Epub 2010 Dec 8.

PMID:
21141896
[PubMed - indexed for MEDLINE]
16.

Synthesis and SAR of geminal substitutions at the C5' carbosugar position of pyrimidine-derived HCV inhibitors.

Verma VA, Rossman R, Bennett F, Chen L, Gavalas S, Girijavallabhan V, Huang Y, Kim SH, Kosinski A, Pinto P, Rizvi R, Shankar B, Tong L, Velazquez F, Venkatraman S, Kozlowski J, MacCoss M, Kwong CD, Bansal N, Kezar HS 3rd, Reynolds RC, Maddry JA, Ananthan S, Secrist JA 3rd, Li C, Chase R, Curry S, Huang HC, Tong X, Njoroge FG, Arasappan A.

Bioorg Med Chem Lett. 2012 Nov 15;22(22):6967-73. doi: 10.1016/j.bmcl.2012.08.111. Epub 2012 Sep 7.

PMID:
23036957
[PubMed - indexed for MEDLINE]
17.

Replicon cell culture system as a valuable tool in antiviral drug discovery against hepatitis C virus.

Horscroft N, Lai VC, Cheney W, Yao N, Wu JZ, Hong Z, Zhong W.

Antivir Chem Chemother. 2005;16(1):1-12. Review.

PMID:
15739617
[PubMed - indexed for MEDLINE]
18.

Novel potent macrocyclic inhibitors of the hepatitis C virus NS3 protease: use of cyclopentane and cyclopentene P2-motifs.

Bäck M, Johansson PO, Wångsell F, Thorstensson F, Kvarnström I, Ayesa S, Wähling H, Pelcman M, Jansson K, Lindström S, Wallberg H, Classon B, Rydergård C, Vrang L, Hamelink E, Hallberg A, Rosenquist S, Samuelsson B.

Bioorg Med Chem. 2007 Nov 15;15(22):7184-202. Epub 2007 Aug 22.

PMID:
17845856
[PubMed - indexed for MEDLINE]
19.

2-(2-Thienyl)-5,6-dihydroxy-4-carboxypyrimidines as inhibitors of the hepatitis C virus NS5B polymerase: discovery, SAR, modeling, and mutagenesis.

Koch U, Attenni B, Malancona S, Colarusso S, Conte I, Di Filippo M, Harper S, Pacini B, Giomini C, Thomas S, Incitti I, Tomei L, De Francesco R, Altamura S, Matassa VG, Narjes F.

J Med Chem. 2006 Mar 9;49(5):1693-705.

PMID:
16509585
[PubMed - indexed for MEDLINE]
20.

A novel class of geldanamycin derivatives as HCV replication inhibitors targeting on Hsp90: synthesis, structure-activity relationships and anti-HCV activity in GS4.3 replicon cells.

Shan GZ, Peng ZG, Li YH, Li D, Li YP, Meng S, Gao LY, Jiang JD, Li ZR.

J Antibiot (Tokyo). 2011 Feb;64(2):177-82. doi: 10.1038/ja.2010.161. Epub 2010 Dec 22.

PMID:
21179047
[PubMed - indexed for MEDLINE]

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