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Items: 1 to 20 of 210

1.

High-throughput fluorescence polarization assay for chemical library screening against anti-apoptotic Bcl-2 family member Bfl-1.

Zhai D, Godoi P, Sergienko E, Dahl R, Chan X, Brown B, Rascon J, Hurder A, Su Y, Chung TD, Jin C, Diaz P, Reed JC.

J Biomol Screen. 2012 Mar;17(3):350-60. doi: 10.1177/1087057111429372. Epub 2011 Dec 7.

PMID:
22156224
2.

A TR3/Nur77 peptide-based high-throughput fluorescence polarization screen for small molecule Bcl-B inhibitors.

Yip KW, Godoi PH, Zhai D, Garcia X, Cellitti JF, Cuddy M, Gerlic M, Chen Y, Satterthwait A, Vasile S, Sergienko E, Reed JC.

J Biomol Screen. 2008 Aug;13(7):665-73. doi: 10.1177/1087057108320918. Epub 2008 Jul 14.

PMID:
18626112
3.

High-throughput screen for the chemical inhibitors of antiapoptotic bcl-2 family proteins by multiplex flow cytometry.

Curpan RF, Simons PC, Zhai D, Young SM, Carter MB, Bologa CG, Oprea TI, Satterthwait AC, Reed JC, Edwards BS, Sklar LA.

Assay Drug Dev Technol. 2011 Oct;9(5):465-74. doi: 10.1089/adt.2010.0363. Epub 2011 May 11.

4.

A dual-readout F2 assay that combines fluorescence resonance energy transfer and fluorescence polarization for monitoring bimolecular interactions.

Du Y, Nikolovska-Coleska Z, Qui M, Li L, Lewis I, Dingledine R, Stuckey JA, Krajewski K, Roller PP, Wang S, Fu H.

Assay Drug Dev Technol. 2011 Aug;9(4):382-93. doi: 10.1089/adt.2010.0292. Epub 2011 Mar 11.

5.

Bcl-2 family member Bfl-1/A1 sequesters truncated bid to inhibit is collaboration with pro-apoptotic Bak or Bax.

Werner AB, de Vries E, Tait SW, Bontjer I, Borst J.

J Biol Chem. 2002 Jun 21;277(25):22781-8. Epub 2002 Apr 19.

6.

Fluorescence polarization and time-resolved fluorescence resonance energy transfer techniques for PI3K assays.

Horiuchi KY, Ma H.

Methods Mol Biol. 2009;572:161-76. doi: 10.1007/978-1-60761-244-5_10.

PMID:
20694691
7.

Robust lanthanide-based assays for the detection of anti-apoptotic Bcl-2-family protein antagonists.

Rega MF, Reed JC, Pellecchia M.

Bioorg Chem. 2007 Apr;35(2):113-20. Epub 2006 Sep 22.

PMID:
16996562
8.

Gambogic acid is an antagonist of antiapoptotic Bcl-2 family proteins.

Zhai D, Jin C, Shiau CW, Kitada S, Satterthwait AC, Reed JC.

Mol Cancer Ther. 2008 Jun;7(6):1639-46. doi: 10.1158/1535-7163.MCT-07-2373.

9.

Characterization of peptide aptamers targeting Bfl-1 anti-apoptotic protein.

Brien G, Debaud AL, Bickle M, Trescol-Biemont MC, Moncorge O, Colas P, Bonnefoy-Berard N.

Biochemistry. 2011 Jun 14;50(23):5120-9. doi: 10.1021/bi101839p. Epub 2011 May 20.

PMID:
21563784
10.

Comparison of miniaturized time-resolved fluorescence resonance energy transfer and enzyme-coupled luciferase high-throughput screening assays to discover inhibitors of Rho-kinase II (ROCK-II).

Schröter T, Minond D, Weiser A, Dao C, Habel J, Spicer T, Chase P, Baillargeon P, Scampavia L, Schürer S, Chung C, Mader C, Southern M, Tsinoremas N, LoGrasso P, Hodder P.

J Biomol Screen. 2008 Jan;13(1):17-28. doi: 10.1177/1087057107310806.

PMID:
18227223
11.

Inhibition of Bfl-1 with N-aryl maleimides.

Cashman JR, MacDonald M, Ghirmai S, Okolotowicz KJ, Sergienko E, Brown B, Garcia X, Zhai D, Dahl R, Reed JC.

Bioorg Med Chem Lett. 2010 Nov 15;20(22):6560-4. doi: 10.1016/j.bmcl.2010.09.046. Epub 2010 Sep 21.

12.

High-throughput methods to detect dimerization of Bcl-2 family proteins.

Whitfield J, Harada K, Bardelle C, Staddon JM.

Anal Biochem. 2003 Nov 15;322(2):170-8.

PMID:
14596824
13.

Development and applications of a broad-coverage, TR-FRET-based kinase binding assay platform.

Lebakken CS, Riddle SM, Singh U, Frazee WJ, Eliason HC, Gao Y, Reichling LJ, Marks BD, Vogel KW.

J Biomol Screen. 2009 Sep;14(8):924-35. doi: 10.1177/1087057109339207. Epub 2009 Jun 29.

PMID:
19564447
14.

Development, validation and implementation of immobilized metal affinity for phosphochemicals (IMAP)-based high-throughput screening assays for low-molecular-weight compound libraries.

Sharlow ER, Leimgruber S, Yellow-Duke A, Barrett R, Wang QJ, Lazo JS.

Nat Protoc. 2008;3(8):1350-63. doi: 10.1038/nprot.2008.111.

PMID:
18714303
15.

Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening.

Enyedy IJ, Ling Y, Nacro K, Tomita Y, Wu X, Cao Y, Guo R, Li B, Zhu X, Huang Y, Long YQ, Roller PP, Yang D, Wang S.

J Med Chem. 2001 Dec 6;44(25):4313-24.

PMID:
11728179
16.

A time-resolved fluorescence resonance energy transfer assay for high-throughput screening of 14-3-3 protein-protein interaction inhibitors.

Du Y, Fu RW, Lou B, Zhao J, Qui M, Khuri FR, Fu H.

Assay Drug Dev Technol. 2013 Jul;11(6):367-81. doi: 10.1089/adt.2013.507. Epub 2013 Aug 1.

17.

Discovery and development of thiazolo[3,2-a]pyrimidinone derivatives as general inhibitors of Bcl-2 family proteins.

Zhou B, Li X, Li Y, Xu Y, Zhang Z, Zhou M, Zhang X, Liu Z, Zhou J, Cao C, Yu B, Wang R.

ChemMedChem. 2011 May 2;6(5):904-21. doi: 10.1002/cmdc.201000484. Epub 2011 Feb 25.

PMID:
21520420
18.

Peptide ligands for pro-survival protein Bfl-1 from computationally guided library screening.

Dutta S, Chen TS, Keating AE.

ACS Chem Biol. 2013 Apr 19;8(4):778-88. doi: 10.1021/cb300679a. Epub 2013 Feb 21.

19.

Development of high-throughput TR-FRET and AlphaScreen assays for identification of potent inhibitors of PDK1.

Xu Z, Nagashima K, Sun D, Rush T, Northrup A, Andersen JN, Kariv I, Bobkova EV.

J Biomol Screen. 2009 Dec;14(10):1257-62. doi: 10.1177/1087057109349356. Epub .

PMID:
19822882
20.

Discovery of novel inhibitors of Bcl-xL using multiple high-throughput screening platforms.

Qian J, Voorbach MJ, Huth JR, Coen ML, Zhang H, Ng SC, Comess KM, Petros AM, Rosenberg SH, Warrior U, Burns DJ.

Anal Biochem. 2004 May 15;328(2):131-8.

PMID:
15113688
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