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Items: 1 to 20 of 122

1.

Bispecific tandem single chain antibody simultaneously inhibits β-secretase and promotes α-secretase processing of AβPP.

Boddapati S, Levites Y, Suryadi V, Kasturirangan S, Sierks MR.

J Alzheimers Dis. 2012;28(4):961-9. doi: 10.3233/JAD-2011-111196.

PMID:
22156046
2.

Inhibiting β-secretase activity in Alzheimer's disease cell models with single-chain antibodies specifically targeting APP.

Boddapati S, Levites Y, Sierks MR.

J Mol Biol. 2011 Jan 14;405(2):436-47. doi: 10.1016/j.jmb.2010.10.054. Epub 2010 Nov 10.

PMID:
21073877
3.

Evidence that the amyloid-β protein precursor intracellular domain, AICD, derives from β-secretase-generated C-terminal fragment.

Flammang B, Pardossi-Piquard R, Sevalle J, Debayle D, Dabert-Gay AS, Thévenet A, Lauritzen I, Checler F.

J Alzheimers Dis. 2012;30(1):145-53. doi: 10.3233/JAD-2012-112186.

PMID:
22406447
4.

Magnesium modulates amyloid-beta protein precursor trafficking and processing.

Yu J, Sun M, Chen Z, Lu J, Liu Y, Zhou L, Xu X, Fan D, Chui D.

J Alzheimers Dis. 2010;20(4):1091-106. doi: 10.3233/JAD-2010-091444.

PMID:
20413885
5.

Matrix metalloproteinase-9 participates in NGF-induced α-secretase cleavage of amyloid-β protein precursor in PC12 cells.

Fragkouli A, Tzinia AK, Charalampopoulos I, Gravanis A, Tsilibary EC.

J Alzheimers Dis. 2011;24(4):705-19. doi: 10.3233/JAD-2011-101893.

PMID:
21321391
6.

Regulated proteolysis of RAGE and AbetaPP as possible link between type 2 diabetes mellitus and Alzheimer's disease.

Kojro E, Postina R.

J Alzheimers Dis. 2009;16(4):865-78. doi: 10.3233/JAD-2009-0998. Review.

PMID:
19387119
7.

Gamma-secretase catalyzes sequential cleavages of the AbetaPP transmembrane domain.

Xu X.

J Alzheimers Dis. 2009;16(2):211-24. doi: 10.3233/JAD-2009-0957. Review.

8.

O-GlcNAcylation promotes non-amyloidogenic processing of amyloid-β protein precursor via inhibition of endocytosis from the plasma membrane.

Chun YS, Park Y, Oh HG, Kim TW, Yang HO, Park MK, Chung S.

J Alzheimers Dis. 2015;44(1):261-75. doi: 10.3233/JAD-140096.

PMID:
25208619
9.

Targeted hydrolysis of Beta-amyloid with engineered antibody fragment.

Kasturirangan S, Sierks M.

Curr Alzheimer Res. 2010 May;7(3):214-22. Review.

PMID:
20088808
10.

Amyloid-β production via cleavage of amyloid-β protein precursor is modulated by cell density.

Zhang C, Browne A, Divito JR, Stevenson JA, Romano D, Dong Y, Xie Z, Tanzi RE.

J Alzheimers Dis. 2010;22(2):683-984. doi: 10.3233/JAD-2010-100816.

11.

Stimulation of non-amyloidogenic processing of amyloid-β protein precursor by cryptotanshinone involves activation and translocation of ADAM10 and PKC-α.

Durairajan SS, Liu LF, Lu JH, Koo I, Maruyama K, Chung SK, Huang JD, Li M.

J Alzheimers Dis. 2011;25(2):245-62. doi: 10.3233/JAD-2011-102085.

PMID:
21403388
12.

Localization and Trafficking of Amyloid-β Protein Precursor and Secretases: Impact on Alzheimer's Disease.

Agostinho P, Pliássova A, Oliveira CR, Cunha RA.

J Alzheimers Dis. 2015;45(2):329-47. doi: 10.3233/JAD-142730. Review.

PMID:
25589722
13.

Beta-amyloid secretases and beta-amloid degrading enzyme expression in lens.

Li G, Percontino L, Sun Q, Qazi AS, Frederikse PH.

Mol Vis. 2003 May 1;9:179-83.

14.

Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.

Martone RL, Zhou H, Atchison K, Comery T, Xu JZ, Huang X, Gong X, Jin M, Kreft A, Harrison B, Mayer SC, Aschmies S, Gonzales C, Zaleska MM, Riddell DR, Wagner E, Lu P, Sun SC, Sonnenberg-Reines J, Oganesian A, Adkins K, Leach MW, Clarke DW, Huryn D, Abou-Gharbia M, Magolda R, Bard J, Frick G, Raje S, Forlow SB, Balliet C, Burczynski ME, Reinhart PH, Wan HI, Pangalos MN, Jacobsen JS.

J Pharmacol Exp Ther. 2009 Nov;331(2):598-608. doi: 10.1124/jpet.109.152975. Epub 2009 Aug 11.

15.

Activation of the α-secretase processing of AβPP as a therapeutic approach in Alzheimer's disease.

Vincent B, Govitrapong P.

J Alzheimers Dis. 2011;24 Suppl 2:75-94. doi: 10.3233/JAD-2011-110218. Review.

PMID:
21422515
16.
17.

Caveolin-1 regulates γ-secretase-mediated AβPP processing by modulating spatial distribution of γ-secretase in membrane.

Kapoor A, Hsu WM, Wang BJ, Wu GH, Lin TY, Lee SJ, Yen CT, Liang SM, Liao YF.

J Alzheimers Dis. 2010;22(2):423-42. doi: 10.3233/JAD-2010-100531.

PMID:
20847442
18.

Immunomodulation of AβPP processing alleviates amyloid-β-related pathology in Alzheimer's disease transgenic mice.

Arbel-Ornath M, Becker M, Rabinovich-Toidman P, Gartner M, Solomon B.

J Alzheimers Dis. 2010;22(2):469-82. doi: 10.3233/JAD-2010-100753.

PMID:
20847413
19.

Characterization of beta-amyloid peptide precursor processing by the yeast Yap3 and Mkc7 proteases.

Zhang W, Espinoza D, Hines V, Innis M, Mehta P, Miller DL.

Biochim Biophys Acta. 1997 Nov 27;1359(2):110-22.

20.

Enhancement of alpha-secretase cleavage of amyloid precursor protein by a metalloendopeptidase nardilysin.

Hiraoka Y, Ohno M, Yoshida K, Okawa K, Tomimoto H, Kita T, Nishi E.

J Neurochem. 2007 Sep;102(5):1595-605. Epub 2007 Jun 7.

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