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Items: 1 to 20 of 90

1.

Genome instability and transcription elongation impairment in human cells depleted of THO/TREX.

Domínguez-Sánchez MS, Barroso S, Gómez-González B, Luna R, Aguilera A.

PLoS Genet. 2011 Dec;7(12):e1002386. doi: 10.1371/journal.pgen.1002386. Epub 2011 Dec 1.

2.

The interface between transcription and mRNP export: from THO to THSC/TREX-2.

Rondón AG, Jimeno S, Aguilera A.

Biochim Biophys Acta. 2010 Aug;1799(8):533-8. doi: 10.1016/j.bbagrm.2010.06.002. Epub 2010 Jun 19. Review.

PMID:
20601280
3.

BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2.

Bhatia V, Barroso SI, García-Rubio ML, Tumini E, Herrera-Moyano E, Aguilera A.

Nature. 2014 Jul 17;511(7509):362-5. doi: 10.1038/nature13374. Epub 2014 Jun 1.

PMID:
24896180
4.

The THP1-SAC3-SUS1-CDC31 complex works in transcription elongation-mRNA export preventing RNA-mediated genome instability.

González-Aguilera C, Tous C, Gómez-González B, Huertas P, Luna R, Aguilera A.

Mol Biol Cell. 2008 Oct;19(10):4310-8. doi: 10.1091/mbc.E08-04-0355. Epub 2008 Jul 30.

5.

R-loops do not accumulate in transcription-defective hpr1-101 mutants: implications for the functional role of THO/TREX.

Gómez-González B, Aguilera A.

Nucleic Acids Res. 2009 Jul;37(13):4315-21. doi: 10.1093/nar/gkp385. Epub 2009 May 18.

6.

An hpr1 point mutation that impairs transcription and mRNP biogenesis without increasing recombination.

Huertas P, García-Rubio ML, Wellinger RE, Luna R, Aguilera A.

Mol Cell Biol. 2006 Oct;26(20):7451-65. Epub 2006 Aug 14.

7.

New clues to understand the role of THO and other functionally related factors in mRNP biogenesis.

Luna R, Rondón AG, Aguilera A.

Biochim Biophys Acta. 2012 Jun;1819(6):514-20. doi: 10.1016/j.bbagrm.2011.11.012. Epub 2011 Dec 20. Review.

PMID:
22207203
8.

The human TREX-2 complex is stably associated with the nuclear pore basket.

Umlauf D, Bonnet J, Waharte F, Fournier M, Stierle M, Fischer B, Brino L, Devys D, Tora L.

J Cell Sci. 2013 Jun 15;126(Pt 12):2656-67. doi: 10.1242/jcs.118000. Epub 2013 Apr 16.

10.

Genome-wide function of THO/TREX in active genes prevents R-loop-dependent replication obstacles.

Gómez-González B, García-Rubio M, Bermejo R, Gaillard H, Shirahige K, Marín A, Foiani M, Aguilera A.

EMBO J. 2011 Jun 24;30(15):3106-19. doi: 10.1038/emboj.2011.206.

11.

Different physiological relevance of yeast THO/TREX subunits in gene expression and genome integrity.

García-Rubio M, Chávez S, Huertas P, Tous C, Jimeno S, Luna R, Aguilera A.

Mol Genet Genomics. 2008 Feb;279(2):123-32. Epub 2007 Oct 25.

PMID:
17960421
12.

Interdependence between transcription and mRNP processing and export, and its impact on genetic stability.

Luna R, Jimeno S, Marín M, Huertas P, García-Rubio M, Aguilera A.

Mol Cell. 2005 Jun 10;18(6):711-22.

13.

AID induces double-strand breaks at immunoglobulin switch regions and c-MYC causing chromosomal translocations in yeast THO mutants.

Ruiz JF, Gómez-González B, Aguilera A.

PLoS Genet. 2011 Feb;7(2):e1002009. doi: 10.1371/journal.pgen.1002009. Epub 2011 Feb 24.

14.

Activation-induced cytidine deaminase action is strongly stimulated by mutations of the THO complex.

Gómez-González B, Aguilera A.

Proc Natl Acad Sci U S A. 2007 May 15;104(20):8409-14. Epub 2007 May 8.

15.

The Npl3 hnRNP prevents R-loop-mediated transcription-replication conflicts and genome instability.

Santos-Pereira JM, Herrero AB, García-Rubio ML, Marín A, Moreno S, Aguilera A.

Genes Dev. 2013 Nov 15;27(22):2445-58. doi: 10.1101/gad.229880.113.

16.
17.

Differential expression of THOC1 and ALY mRNP biogenesis/export factors in human cancers.

Domínguez-Sánchez MS, Sáez C, Japón MA, Aguilera A, Luna R.

BMC Cancer. 2011 Feb 17;11:77. doi: 10.1186/1471-2407-11-77.

18.
19.

The contribution of co-transcriptional RNA:DNA hybrid structures to DNA damage and genome instability.

Hamperl S, Cimprich KA.

DNA Repair (Amst). 2014 Jul;19:84-94. doi: 10.1016/j.dnarep.2014.03.023. Epub 2014 Apr 18. Review.

20.

DNA-RNA hybrids contribute to the replication dependent genomic instability induced by Omcg1 deficiency.

Houlard M, Artus J, Léguillier T, Vandormael-Pournin S, Cohen-Tannoudji M.

Cell Cycle. 2011 Jan 1;10(1):108-17. Epub 2011 Jan 1.

PMID:
21191184
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